Real-time overlay of real and computer-generated images for cancer diagnostics, neurosurgery, more
Researchers at the University of Arizona (UA) have developed a prototype of a new microscope technology that could help surgeons work with a greater degree of accuracy. The new technology, call augmented microscopy, overlays images depicting diagnostic information such as blood flow and cancerous tissue over real images of blood vessels and other tissues and structures being viewed in the microscope.
These are custom colored dye solutions with randomly plated ICG solution: (a) visible view through microscope, (b) NIR view seen on computer monitor, and (c) augmented view seen in real time through the ocular of the augmented microscope.
Credit: © the authors, Journal of Biomedical Optics doi:10.1117/1.JBO.20.10.106002
A report on the work by Jeffrey Watson and co-authors from the UA departments of Biomedical Engineering and Surgery was published today in the Journal of Biomedical Optics, published by SPIE, the international society for optics and photonics.
Surgical microscopes are highly specialized stereomicroscopes installed on articulated mounts and provide a long working distance and functional enhancements, and are widely used in certain delicate operations, notably neurosurgery.
Within the last decade, surgical microscopes have been combined with near-infrared (NIR) fluorescence imaging, in which contrast agents are injected into tissue and their fluorescence detected in NIR scans. The scans may reveal patterns of blood flow, or differentiate cancerous from normal tissue.
But there are limitations. For example, some microscopes used in complex vascular surgeries switch between two different views: the fully optical bright-field (real) view and the computer-processed projection of NIR fluorescence. The NIR image is two-dimensional, and on its own lacks the spatial cues that would help the surgeon identify anatomical points of reference. So the surgeon must visualize how the fluorescence in the NIR image lines up with the respective anatomical structures shown in the bright-field view.
The UA researchers' article, "Augmented microscopy: Real-time overlay of bright-field and near-infrared fluorescence images" describes their prototype of an augmented stereomicroscope that presents a simultaneous view of real objects in the surgical field and computer-processed images superimposed in real time.
"Surgeons want to see the molecular signals with their eyes, so that they can feel confident about what is there," said journal associate editor Brian Pogue of Dartmouth College. "Too often, what they see is a report of the signals depicted in false color on a monitor. By displaying information through the surgical scope itself, the surgeon then sees the information with his or her own eyes."
Pogue said he sees the work being important in advancing the translation of research into clinical practice. "There are very few papers on this idea of augmenting the surgical field of view that the surgeon sees, yet this is a high-interest topic," he said. "This article presents a very practical idea and innovative implementation which is well done technically."
The prototype offers advantages over earlier versions of augmented microscopes. By utilizing the optical path of the stereomicroscope, it maintains full three-dimensional stereoscopic vision, which is lost in fully digital display systems.
It also retains the imaging environment familiar to surgeons, including key features of surgical microscopes such as real-time magnification and focus adjustments, camera mounting, and multiuser access.
One possible application for this augmented microscope is laser surgery. In the past, surgeons could not see the laser beam through the standard stereomicroscope, nor anatomical details in the NIR images.
The researchers also suggest that this technology will be useful in the surgical treatment of brain tumors. Surgeons aggressively removing a tumor run the risk of damaging normal brain tissue and impairing the patient's brain functions; on the other hand, incomplete removal of a tumor results in immediate relapse in 90% of patients. Being able to simultaneously see the surgical field and the contrast agent identifying cancerous tissue within the augmented microscope may allow surgeons to remove these challenging tumors more accurately.
The work was supported by funding from the National Institutes of Health.
Lihong Wang, Gene K. Beare Distinguished Professor of Biomedical Engineering at Washington University in St. Louis, is editor-in-chief of the Journal of Biomedical Optics. The journal is published in print and digitally in the SPIE Digital Library, which contains more than 430,000 articles from SPIE journals, proceedings, and books, with approximately 18,000 new research papers added each year.
SPIE is the international society for optics and photonics, an educational not-for-profit organization founded in 1955 to advance light-based science and technology. The Society serves nearly 264,000 constituents from approximately 166 countries, offering conferences and their published proceedings, continuing education, books, journals, and the SPIE Digital Library in support of interdisciplinary information exchange, professional networking, and patent precedent. SPIE provided more than $4 million in support of education and outreach programs in 2014. SPIE is a Founding Partner of the International Year of Light and Light-based Technologies and a Founding Sponsor of the U.S. National Photonics Initiative. http://www.
Amy Nelson | EurekAlert!
New technique makes brain scans better
22.06.2017 | Massachusetts Institute of Technology
New technology enables effective simultaneous testing for multiple blood-borne pathogens
13.06.2017 | Elsevier
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
23.06.2017 | Physics and Astronomy
23.06.2017 | Physics and Astronomy
23.06.2017 | Information Technology