Domain-exchanged complete antibody composed of the Fc fragment and variable domains where CH1 and CL domains have been exchanged for a pair of CH3 domains.

Modular immunoglobulins composed of Fab-like fragment with HerceptinVL and VH region and CH3 domains and an unmodified Fc fragment are described. Novel is an increased binding to FcR³III, which leads to potentiated T-cell activation upon binding to a Her2-positive cell line

A new aluminum based photo acid generator which is easy to synthesize[2, 3] (sulphonium as weil as iodonium salt) at high yields is described. The educts are inexpensive and commercially available. This high stability and the abandonment of any heavy metals in our novel PAG prompts a low toxicity.

Die Erfindung dient zur Verhinderung von Tauwasserbildung an den Tramköpfen einer Holzbalkendecke bei Innendämmung. Die Wärmeleitbleche ermöglichen eine energiesparende Temperierung des Tramkopfs und somit eine dauerhafte Sanierung und Erhaltung der Tramdecke.

The invention prevents the condensation of water forming on the traverse heads of a wooden beam ceiling when the building is insulated internally. Using heat conduction plates enables energy-saving temperature control of the beam head area and thus durable renovation of a wooden beam ceiling.

The new type of solar cells contains copper oxide phases as a photovoltaic absorber film in combination with e.g. AlGaN, ZnMgO, or ZnBeO thin film. These are non-toxic and their production is possible in industrial scale (e.g. using the cathode sputtering technique) and with low energy consumption.

The presented innovation is a new method for head measurement which works with an app. Scopes of application of the new method can be found in the field of diagnosis and treatment of cranial deformations, e.g. the helmet therapy.

Among Gram-positive bacteria are some of the most dangerous pathogens for humans. Especially Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for a high percentage of hospital-acquired and deadly infections.
We have identified a naturally human-associated bacterial antibiotic producer strain (S. lugdunensis IVK28 wild type), which may act as a probiotic cure before patients enter hospital. Its application could avoid costly decolonization of human commensal bacteria before surgery.
From this bacterium we furthermore isolated a previously unknown class of peptide related structures with high potential as new antibiotics. Total chemical synthesis has been established.
The main compound Lugdunin shows very high potential against MRSA and other highly-resistant species like Enterococcus faecalis, E. faecium (VRE), Streptococcus pneumoniae and Listeria monocytogenes.
A patent application covering the chemical structures, the genetic background of the producer strain and the bioactivity of the new substances has been filed.

Sensitive sensors and other electronic and optoelectronic components require reliable capsulations, which withstand long-lasting environmental difficulty. Such housings, with grommets for electrical connections in surroundings with low air or rather gas pressure and in the vacuum technology, require particularly high standards.

Inventors of Saarland University achieved to develop new neutral bis azainositol heavy metal complexes suitable for the use as X-ray contrast agents with a wide range of advantages compared to common contrast agents. For their higher absorption coefficient in the range of voltages used in CT these complexes lead to scan protocols that provide equivalent or even improved diagnostic value at lower radiation doses compared to conventional triiodinated contrast agents.

A novel Fourier Transform Infrared (FTIR) spectroscopy based approach for rapid and reliable differentiation of fresh from frozen/thawed meat or fish. This fast and inexpensive high throughput technique represents a powerful tool to ascertain correct labeling of meat and fish.

Gerät zur Messung von mechanischen Eigenschaften von Böden und Oberflächen, dass ohne Führungselemente auskommt, keine Sensoren für Weg oder Geschwindigkeit benötigt und Energierückgewinnung, Federkonstante, Kraftreduktion und Resonanzfrequenz misst.

A new and cost saving method makes it possible to combine different components of any form. Manyfold material combinations such as carbon fiber composites and metals can be combined easily. With the material friendly technique high quality welding seams can be manufacured in a flexible manner without affecting the components global-thermally.

Scientists at the University Göttingen developed a monoclonal antibody against a biotinylable peptid (Epitope-Tag) called AP-tag or Avi Tag. This small peptide served as a substrate mimic for biotin ligase (BirA). Anti-AP antibodies are useful tools in the analysis of AP-tag fusion proteins.

The technology enables the fast and competitive production of specific ALA via biotechnological process technology. The production of aminolevulinic acid (ALA) is the first step in the biosynthesis of tetrapyrroles and porphyrines (like Chlorophyll, vitamin B12, heme). Recently ALA has attracted interest as a selective and biodegradable herbicide and insecticide. Besides ALA can be applied in the photodynamic therapy and treatment of various kinds of cancer.
Administration of ALA in the tumorous tissue leads to a porphyrin formation inside the cells. Accumulated porphyrins generate reactive oxygene species when excited by light which can lead to death of the tumorous cell. On behalf of the University of Bielefeld, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development.

By decoupling cell growth and productivity of biosynthesis the new method and associated Escherichia coli strain allow for an increase in productivity by a factor two to three.
This could not only be interesting for pharma industry, e.g. by increasing the capacity of insulation production, but for biotechnological synthesis of succinic acid as well. The demand for succinic acid as a component of plastics such as polyamides or polyesters is estimated to amount to 250,000 tons per year.

The invention presented here consists in the fact that via pow-der/air/water jet devices, induced through the special geometry of the instrument approach the cleaning powder/water jet is released in such a way that even the undercuts of the implant?s surface are cleaned effectively.

Through photosynthesis, solar energy is converted into biological energy. It is often thought that photosynthesis becomes stronger as light becomes stronger,…

A novel mesh generation method enables a fast, fully automatic generation of high-quality meshes even for complex geometrical structures.

DNA lesions occur in all living organisms. As accumulating DNA damage poses a risk for cell survival, cells harbour sophisticated mechanisms for repairing such lesions. The kinase ATR (“ATM and Rad3 related”) is a key player in triggering the cellular response to double strand DNA breaks called “DNA Damage Response” (“DDR”) thereby enabling DNA repair and thus promoting cell survical.

As cancer cells are often characterized by defects in various DNA repair processes and/or DNA damages, intact ATR-signalling (and subsequent DNA-repair processes) is particularly crucial for the viability of such cancer cells.

In fact, blocking DDR, preferably by inhibiting ATR has become an attractive therapeutic concept.

Correspondingly, at present, two ATR inhibitors (VX-970 and AZD5738; for ref. see “Relevant Publications”) have already entered clinical studies.

However, both with the developmental risk associated with these compounds, the need for compounds displaying an improved safety-/efficacy-profile and the large number of patients, there is a huge interest in advanced ATR inhibitors.

The present invention thus relates to advanced ATR antagonists which have proven to be effective in various in cellular assays (both on its own and in combination with cisplatin). Furthermore they show a promising ADME-profile as deducted from predictive ADME modelling and an improved solulibility in relation to the aforementioned compounds.

Selective Enhancement of Ligands by Exponential Enrichment (SELEX) has proven to be a powerful tool for idenfying functional oligonucleotides which bind to selected targets. Here, in an iterative process, a pool of single stranded oligonucleotides is contacted with a target structure (e.g. a protein), high-affinity oligonucleotides are then isolated, amplified and again put into contact with the target until, eventually, an ideal oligonucleotide has been obtained.
An International and a European patent application are pending. On behalf of University of Bonn, PROvendis offers licenses for commercial use as well a research collaboration with licensing option.