Mutations in the lysosomal enzyme ß-glucosidase 1 (GBA1) cause Gaucher’s disease, the most common lysosomal lipid storage disease in humans. When GBA1 is absent or impaired, glycosylceramide (GlcCer) accumulates within the macrophage lysosomes, leading to liver and spleen enlargement, bone lesions and in the most severe cases, impairment of central
nervous system functions.

Production process of wood composites combining hot air and hot steam. This reduces the production time, production line and enables the use of any current binder.

In a collaboration scientists from the University of Göttingen and of the University of Bielefeld developed a procedure for the production of recombinant isolated active eukaryotic full lenght C-alpha Formylglycine-Generating Enzyme (FGE) in selected eukaryotic cells for biotechnological and therapeutic uses.

Innovative Furane-Pyrene derivatives to be used for organic light emitting diodes (OLEDs) have been synthesized at the University of Göttingen. They show an increased efficiency of the blue emission spectra and stability during doping and de-doping in polymer films.

The invention comprise a method to synergistically integrate bottom-up nano-technology with single-molecule fluorescence spectroscopy to create a platform for a single-molecule lab-on-a-chip that enables paralleled investigation of enzyme reactions, binding- and drug-screening assays in confined volumes at biologically relevant concentrations. The method allows the paralleld placement of different molecules at precisley defined positions next to the optical antennas.

The constantly growing global population and the resulting increase in energy consumption, the foreseeable end of the global petroleum reserves and a need for stagnation or rather a decline of the emissions of greenhouse gas led to a closer focus on alternative energy sources. Especially the production of biofuel out of renewable, cellulosic raw material is constantly being optimized at the moment. One major challenge in this context is the generation of new, highly effective cellulolytic enzymes. Our novel assay, called hydrogel reagent signaling system (HyReS), offers significant advantages, as it enables a straightforward method for analyzing cellulolytic enzymes with a spatially-resolved imaging of cellulose hydrolysis in real-time using a simple fluorescent readout.

The present invention provides a novel method for the production of exopolysaccharides, in particular glucans and fructans. The special feature of method according to the invention is that the production of EPS is a non-recombinant technology, and that the purification of the produced EPS is furthermore possible simply by filtration, centrifugation, ion exchange or dialysis. The result is an enormous yield of high quality EPS in a highly purified form with uniform particle size, which can be used in several areas such as food industry, pharmaceutics, cosmetic industry, paper industry, polymer industry and chemical industry.

During vertebrate skeletal development, osteoblasts produce a mineralized bone matrix by deposition of hydroxyapatite crystals in the extracellular matrix. Anoctamin6/Tmem16F (Ano6) belongs to a conserved family of transmembrane proteins. The gene Ano6 encodes a Ca-activated chloride channel. In addition, Ano6 has been linked to phosphatidylserine (PS) scrambling in the plasma membrane. During skeletogenesis, Ano6 mRNA is expressed in differentiating and mature osteoblasts.
Tmem16f-deficient mice were generated by complete gene deletion.

Kidney cancer is classified as malignant tumors originating from different renal cells with several subtypes. The cells of these subtypes can mimic a benign kidney tumor, called oncocytoma. The unequivocal differentiation is essential for planning the
adequate operative procedure (tumor removal [oncocytoma] or complete kidney resection with lymph node preparation [malignant kidney cancer]) and potential follow up (not necessary in oncocytoma).

NEG layers (non-evaporating getter) are able to remove the majority of gases from a high vacuum device at room temperature. In doing so, they also capture the gases released from the carrier material. After being activated, the NEG film is a clean metal surface which facilitates a high pumping speed and lower level of outgassing. Up to now, its usage has been limited due the time-consuming and complex method used for its production.

The invention allows reconstructing the shape of a droplet with the help of reflections of a light source. Hereby, the contact angle between the droplet and the substrate as well as the droplet volume and other parameters can be determined. Through a vertical view many droplets can be captured automatically and synchronously. The procedure simplifies the conventional determination of wettability parameters of new surfaces and can be applied wherever many droplets need to be captured and analyzed at the same time.

Especially infections by multi-resistant bacteria are more and more common and have developed into a major health concern in many facilities around the world. The present invention relates to a method for the preparation of a strain-adapted vaccine specific for a bacterial strain based on OMVs.

Medical implants are widely being used in orthopaedics and in modern dentistry. While significant progress has been made to improve the production of implants using the most advanced materials and technologies, there is still need for additional strategies to improve and accelerate osseointegration. The improper integration of the implant material in the living bone can impair the healing process and limit the freedom of movement thereby rendering the implant useless.

The invention provides a multilayer bio-nanocoating
to improve significantly the adhesion of osteoblasts to the implant, which is shown in Fig.2. The applied bio-nano-coating is tightly connected to the implant and at the same time ensures flexibility of the molecular layers. Further the bio-nano-coating enables the native
conformation of embedded molecules, e.g. of fibronectin. Data from animal models are available for dental applications.

In summary, the invention comprises medicinal
implants with biofunctional coating, which will greatly reduce the incidence of periimplantitis and other complications related to the insufficient adhesion of the tissue to the implant.

The presented invention describes a method for increasing the efficiency of solar cells of so-called hot carrier at more than 30% by the rapid separation of hot electrons and holes in each band prior to cooling. The object is solved by the use of a specially adapted for this purpose, a double hetero structure which has never been used for the separation of the hot carrier in a hot carrier solar cell.

The invention relates to processes for the oligomerization of olefins, in particular of ethene, which are catalyzed by the complexes or catalyst systems in accordance with the invention.

This technology allows a cell manipulation system that is easy to manufacture, and the manipulation yields more reproducible results.

DUTiX is a hardware- und power-efficient transmitter architecture for modern, digital-centric radio transmitters, suitable for mobile communication, connectivity, WiFi and other radio applications. The core of the invention is a dedicated digital signal processing block which enables a direct transfer from baseband (BB) to local oscillator (LO) domain—allowing arbitrary sample ratios, and even works with a modulated LO as in polar transmitters. DUTiX is suitable for all modulation techniques and schemes, including IQ modulations as QAM and OFDM, there are no limitations for all applications. The clock domain crossing is realized in three steps. After clock domain synchronization, the baseband data is upsampled employing a novel, highly-efficient filter which combines the classical polyphase filter approach with lookup tables and a linear filter coefficient interpolation. The filter uses common FIR filter coefficients. A time control unit calculates the correct sample positions and required interpolation steps depending on the both BB and LO clocks and reliably avoids sampling errors.

The microtubule associated tau-protein in its hyper-phosphorylated form is a key element in diseases of the nervous system, the so- called tauopathies.
We offer a neuronal model system with an missfolded Tau protein that is based on a poly-mutant MAPT-gene variant.

Generative manufacturing of a component, in combination with specific directional, three-dimensional fiber structure: The component strength is locally influenced by the addition of fibers. In particular, the local orientation of the fibers allows optimal design even for lightweight construction. The invention can be applied in the areas of rapid prototyping, automotive, aerospace, medical and shipbuilding.

The SQUID is an autonomous robot system that is suspended from several cables. The robot is able to move freely and independently in all three axes by changing the cable lengths. Unlike driving or walking robots, this system is independent of the ground and very robust.
Various sensors facilitate orientation in space, as well as the localization of people and objects. The SQUID uses these sensors to react independently to a changing environment and to learn complex tasks.
This means that the SQUID can combine a broad range of active elements, such as a light source or toolholder, with the appropriate sensor technology or an intelligent controller. The system could also be controlled by means of a Smartphone App.