Fourier transform-infrared measuring device including a specific measuring cell, which realizes real-time analysis of a sample. Application field of the…
Many modern computer applications use data compression methods like bzip2 or gzip. Those algorithms do not allow the processing of data in its compressed form,…
The present invention relates to antibodies that exhibit a high affinity and specificity for the A1/B-domains of CEACAM1.
Commercial Opportunities…
The present invention relates to antibodies that exhibit a high affinity and specificity for the A1/B-domains of CEACAM1.
Commercial Opportunities
CEACAM1 is an adhesion receptor molecule implicated in growth regulation and the development of cancer. It belongs to the family of carcinoembryonic antigens which forms a part of the immunoglobulin superfamily (IgSF). CEACAMs play a central role with respect to cell adhesion, differentiation, activation, proliferation, morphogenesis and apoptosis as well as receptors for various pathogens (e. g. bacteria). CEACAMs are structurally closely related: they feature the function triggering N-domain and a C-domain consisting of A- and B-domains. Due to the structural similarity it is very challenging to obtain antibodies against specific CEACAM1-domains. CEACAM1 has been detected at elevated levels in the surrounding tissue of tumors and the tumors themselves. It appears that CEACAM1 is a suitable biomarker for the diagnosis and staging of tumors.
The present invention relates to antibodies that exhibit a high affinity and mono-specificity for the A1/B-domains of human CEACAM1. Thus, they are suitable to detect the membrane anchored, the cleaved soluble CEACAM1 and most of its derivatives and may be used in various in-vitro techniques in cancer research, e.g. ELISA, WB, IHC, fluorescence microscopy and flow cytometry.
ManyThe novel combination therapy, developed at the Julius-Maximilians-Universität Würzburg, is based on a combined treatment strategy using glucocorticoids
combined with inhibitors of the proteasome . The new therapy effectively and significantly reduced edema formation and moreover significantly ameliorated neurological performance in mouse models of stroke and
brain trauma….
The current invention is based on combination therapies of nucleoside analogs with inhibitors of either the Nodal/Activin pathway or the mTOR / hedgehog…
Natural products that elicit specific and unique biological responses in mammalian cells represent valuable tools for new therapeutics in the treatment of…
The invention is based on the finding that the proteins Calmodulin-like protein 5 (CALML5) and Calponin-h2 (CNN2) are upregulated in the nuclear matrix of…
Physiologically, the tear film lubricating the eye is composed of three layers: the mucus layer, the aqueous layer and the lipid layer. Conjunctival goblet…
Scientists of Saarland University have developed a method, which automatically finds the appropriate song for a picture, a set of pictures, or a video. The…
Arginine deiminase (ADI) produces depletion of arginine and has been studied as a potential antitumor drug for the treatment of arginine-auxotrophic tumors…
In cardiovascular, respiratory, kidney and haematological diseases transplantation remains the most effective long term therapy for patients with advanced…
Highly adherent and scratch-resistant coating is required to protect certain surfaces efficiently against erosion. The invention presented here consists in…
Founded in 1954, the SAG collection today comprises around 2400 strains (representing 538 genera and 1424 species) from almost all evolutionarylineages of…
Gfi1 is a transcriptional repressor being expressed in the hematopoietic and nervous system. Loss of function leads to severe defects in hematopoiesis and…
The here presented Technology allows to separate polarizable bioparticles such as bacteria from each other and to cultivate them under flow and environmentally…
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