Porous carbon or activated carbons are important materials for the purification of gases and liquids. They are used as adsorbents in medical applications as well as electrode materials in batteries. The presented invention provides a process for the production of porous carbon by embedding inorganic nanoparticles into a carbonaceous matrix followed by a reaction with a halogen gas. The resulting material is Kroll-Carbon, a highly porous carbon material with a hierarchical pore architecture, containing well-defined micropores and adjustable mesopores.
It is suitable for applications in separation and purification, like the removal of VOCs (volatile organic compounds), and biomolecules, but also for the encapsulation of enzymes, or as a electrode material for supercapacitors and batteries.
The innovative technology provides binary precursors, which keep all advantages of the known precursors TBAs and TBP, but deliver two group-15 el-ements in a defined molar ratio in one chemical component (one-component precursors). Any pairs of group-15 elements (N, P, As, Sb and Bi) may be combined in these components.
The new technology provides a simple and inexpensive process for the synthesis of proteins that exhibit reliable functionality by posttranslational modifications, like e.g. glycosylation. Furthermore, the assembly of protein complexes is enabled. These are secreted from the cells into the medium and can be therefore easily obtained.
Novel peptidomimetic furin inhibitors strongly inhibit the furin-dependent activation of several viral surface proteins and bacte-rial toxins. Therefore, these inhibitors are a promising new approach for the treatment of diseases, which are caused by furin-dependent infectious agents.
Such diseases are for example influenza, measles, mumps, yellow fever, canine distemper, anthrax, and diphtheria.
The new chimeric nucleases exhibit an increased preference and specificity for DNA cleavage sites composed of two or three recognition sites and allow single cuts in the genome which reduces the toxic side effects substantially.
The high specificity and preference of the new chimeric nucleases is based on a fusion of TALE proteins as DNA binding modules with a highly specific restriction endonuclease, PvuII, as DNA cleavage module.
A major challenge of construction within existing contexts is that renovated as well as newly built supporting structures have to comply with similar requirements regarding statics and outer appearance. E.g. component connections have to comply with standards in the fields of fire protection, corrosion protection and protection of historical monuments. Steel elements pasted into wood provide a solution for these rquirements.
GNSS enables the determination of positions by the help of a carrier phase with an accuracy down to some centimeters. The GNSS receivers typically determine the carrier phase by help of a phase locked loop continuously. However, up to now GNSS receivers are tracking the carrier phase of each satellite and each frequency separately. This is a big drawback since the strong spectral and spatial correlation between carrier phases is not being exploited which makes phase tracking error-prone. Furthermore, this leads to a number of phase jumps especially with low-cost GNSS receivers. The new patented invention comprises a vector phase tracking method, which processes the carrier phases of all visible satellites on all available frequencies simultaneously, thus using the spectral and spatial correlation of the measurement. It enables a continuous, smooth tracking of carrier phases, even when the signal strength (C/NO) of individual satellites breaks down by 20 dB. Therefore the method is very suitable for the use of low-cost GNSS receivers/antennas in environments with multiple faults and ionospheric scintillations.
Device for machining with rotatory ultrasound-vibrations: Reduced tool wear, very fine surface roughness and only little feathering of workpieces prove the advantages of hybrid manufacturing processes such as ultrasound machining. A newly developed device for machining combined with rotatory ultrasound oscillations enables a low-wear and thus more efficient processing of high performance materials such as hard metal, ceramic and fiber-reinforced plastics, compared to conventional methods.
Method for production of a mechanical stable and flexible polymer based ion conducting solid state polymer electrolyte membrane for the use in lithium based accumulators.
The invention describes a combined electricity generation and storage system, preferably based on renewable burnable gases e.g. from biogas plants or biomass gasification.
Spinal muscular atrophy (SMA) is an autosomal recessive disorder based on the loss of the survival motor neuron 1 (SMN1) genes. The severity of the disease is inversely correlated with the copy number of the main disease modifying gene SMN2.
In rare cases, siblings of SMA patients do not show SMA, although they carry exactly the same SMN1 and SMN2 gene status as their SMA affected relatives. So other genetic factors are able to fully protect homozygously SMN1-deleted individuals from developing SMA. The inventors found that this phenomenon might be caused by the overexpression of plastin 3, an actin-bundling protein, and/or low expression levels of the calcium sensing protein neurocalcin delta (NCALD). In vitro and in vivo studies show that inhibitors of neurocalcin delta (NCALD) are suitable for treating and preventing such disorders in a patient. Said inhibitors are, likewise, effective tools for in vitro neuronal differentiation and maturation, and restoration of impaired endocytosis.
Light-sheet-based fluorescence microscopy (LSFM) is a powerful method to analyze 3D living or fixed biological samples – such as cell cultures, embryos, or tissue – with high temporal resolution. The novel sampling device facilitates high-throughput LSFM measurements without loss of imaging quality.
Light-sheet-based fluorescence microscopy (LSFM) is a powerful method to analyze 3D living or fixed biological samples – such as cell cultures, embryos, or tissue – with high temporal resolution. An advanced method has been developed to minimize negative effects due to bleaching and light-induced stress. Additionally, it is suited for larger sample sizes.
In orthodontics, there is a multitude of intraoral devices and wires that can be activated by bending. However, due to restricted access, wire bending is often difficult if not impossible, especially in the palatine region and lingual of the mandible. Moreover, in many cases mirror-inverted pliers would be necessary for respective bending on the other side of the oral cavity. So far, there are no orthodontic pliers available, that enable ergonomic wire bending on both sides of the oral cavity. The present invention solves this problem by connecting the two handles with an olong hole system. According to the invention, the one-prong branch can be swiveled to the other side of the two-prong branch, thus allowing mirror-inverted application. A locking mechanism is activated when the pliers are closed to prevent accidental shifting of the branches. Another aspect of the invention is an convenient working angle between branches and handle, which facilitates intraoral application. A design model is available for demonstration.
The technology describes novel ionic liquids. With this technology a directed choice of substituents, attached groups and the anion is possible which makes it possible to create ionic liquids with special properties for different applications.
The method allows very consistent classification of tumor entities (especially brain tumor sub-types) by analyzing the methylation pattern of genome wide CpG positions.
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