Design and method for positive locking torque transmission. Common steel wheels can be combined with modern carbon composite shafts. Chipping process steps become unnecessary due to the integration in the shaft manufacturing process.
The present invention provides a stent remover for open surgery which can be used to safely remove a stent without causing tissue damage. In a first step, at least three wires are threaded through the mesh of one end of the stent. Then, all wire ends are fed through a sleeve and fixed with a crimping device. Afterwards, the wires in the sleeve can easily be introduced into the funnel-shaped tube of the stent remover. By operating the turning knob of the device, a uniform and controllable pulling force is exerted to the wires. In this way, the stent constricts evenly and can easily be removed without serious tissue damage. In addition, stent removal with this novel device shortens the operation time, thereby reducing the potential for unforeseen complications. On behalf of RWTH Aachen University, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development.
In principal all known conventional satellite navigation systems like GPS, Galileo, GLONASS, QZSS and BeiDou are enabling the determination of the position with accuracy on the centimeter-level by help of the carrier phase. However, the carrier signals, upon which the navigation signals are modulated, are typically impaired by various error sources, like ionospheric errors, tropospheric errors, instrumental errors and/or other error sources, leading to a defective determination of the position. The invention enables a precise and reliable relative positioning (relative kinematic positioning – RTK) with centimeter-level accuracy in urban environments as well as a precise attitude determination (heading estimation with 0.25°/m accuracy) with low-cost sensors. Wit the new method the above mentioned errors can be
eliminated reliably.
The invention concerns hybrid carbon fibre composite parts, whose surfaces are trued up by foils, additional surface processes are obsolete.
CF flanges are well-established components for building ultra-high-vacuum environments. There are several geometries of the tubes that follow the ISO/TS 3669-2 standard, so that the costumer can combine products from different companies.
Nevertheless, a rather tricky task remains: For sealing the contact points between two different CF flanges, the technician has to mount a thin gasket between the two outer ends of the flanges before tightening the bolts. The gasket is typically made of high purity copper. When tightening the bolts, the extruded metal leads to a leak-tight seal (see Figure 1). Mounting and positioning of the copper seal still remains manual work – the technician has to fix the ring in the right position until the bolts hold the two flanges in place. Even if the technician is well trained, the gasket is likely to move and drop out when handling heavy components (pumps, evaporation devices, sections of the vacuum system, etc.). This is a waste of time and money – the damaged copper gasket can’t be reused.
Our new positioning device eliminates the need for this tedious and rather complicated positioning of the sealing ring by hand.
A novel divergent nozzle design, which provides for a homogeneous flow profile even at long distances from the nozzle exit, was developed at the University of Stuttgart. The flow profile is optimized by a central body, shaped and placed in the flow channel in such a manner as to achieve a uniform flow and temperature distribution at the target object. Based on these characteristics, the invention is particularly suited to be used as a long range nozzle for large penetration distances in drying and ventilation applications.
The new copper-oxygen adduct complexes for the first time are thermally stable at room temperature (and above) as well as in oxygen-containing atmosphere, i.e. stable as a solid and are suitable for being used as oxidation catalysts, especially in in-dustrial chemistry, e.g. for the oxidation of benzene to phenol or of methane to methanol, for the oxidation of hydrogen, aromatic and aliphatic, saturated and unsaturated hydrocarbons as well as alcohols and amines.
The adamantane moiety is a very versatile chemical core-structure. It is e.g. incorporated in medically active compounds like Vildagliptin®, a remedy against diabetes.
The innovation presented here provides a new and straightforward way for synthesizing this new class of 1,2-substituted dia-mondoids, which can well be used as intermediate starting ma-terials for further chemical synthesis.
Surface activation or cleaning by cold plasma is getting more and more attention. Current plasma-based solutions for flexible materials however lack efficiency or are technically too complex and error-prone. Scientists at the HAWK developed a plasma roller device for effective and fast plasma treatment of flexible materials.
The invention describes a CAR which recognizes CD30 as a target antigen and initiates lysis of CD30-positive (CD30+) tumor cells but not of CD30+ healthy cells like hematopoietic stem cells. Specific genetic modifications of the anti-CD30 CAR ensure the specific targeting of CD30+ tumor cells and prevent unwanted side-effects. This approach has been tested in vitro with CD30+ hematopoietic stem cells and CD30+ tumor cells and in vivo in mice transplanted with human CD30+ hematopoietic stem cells. In vivo experiments provided evidence that the treatment with anti-CD30 T-cells has no unwanted impact on the endogenous immune system. Thus, the CAR is most suitable for clinical application in targeting CD30+ leukemia and lymphoma cells. A clinical study phase I is planned for early 2016, indication: cutaneous T-cell lymphoma.
Adoptive T-cell therapy is a very promising approach in the treatment of cancer. Early phase clinical trials with genetically engineered T-cells expressing a tumor-specific chimeric antigen receptor (CAR) show significant efficacy in the treatment. However, currently used CAR modified T-cells for antigen-directed targeting towards tumor cells have insufficient performance in the anti-tumor attack, e. g. less amplification and cytolytic activity after the transfer of the modified T-cells into the patient. Scientists from the University Medical Center of Cologne developed a bispecific CAR, which improves the performance of genetically engineered T-cells expressing these CAR polypeptides on their surface. The bispecific CAR comprises two antibody units, with one antibody unit being an anti-CD30 single chain antibody unit and the other antibody unit being an antibody unit specific for an antigen present on the surface of a predetermined target cell, e. g. for the tumor carcino-embryonic antigen (CEA) on breast cancer cells.
Biological coatings have a high potential for manifold applications, especially for medical applications or biodegradable coatings. Up to now, the formation of biological coatings is accompanied either by a low control over film formation or connected to high costs. Current challenges that need to be overcome are a high control over the film thickness, an even and continuous coating of objects with a complex geometry, or the site-specific coating of single areas on one object. The new concept Enzymatic Bio-Coating is able to solve these Problems. Suitable supports are: Glass, wood, and miscellaneous plastics and metals.
Casein layers are antibacterial, edible, and renewable.
Auf Grundlage eines neuen Oxidationsverfahrens wurden Gassensoren entwickelt, die ohne die sonst notwendige Sensorheizung auskommen. Das besondere Verfahren der potentiostatisch und galvanostatisch kontrollierten plasma-elektrolytischen Oxidation (PEO) ermöglicht dabei die Herstellung einer mechanisch stabilen TiO2-Schicht mit exzellenter Adhäsion auf einer Titanfolie.
This new biomarker provides a convenient and reliable assay for the detection and differentiation of Fusarium from other fungal pathogens, especially Aspergillus.
The radial adjustable suction hood increases the efficiency of the chip waste handling.
The THz Time Domain Spectroscopy (THz-TDS) offers unique possibilities to obtain information about the structure and composition of a series of material classes, in particular dielectric materials. This technology can be used as a routine application in inline monitoring in the food, plastics and paper industries, as well as in the security sector.
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