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Nuclear Calcineurin Inhibitor: Targeting Myocardial Disorders

Thesignallingcascadeofcalcineurin(CnA)andthenuclearfactorofactivatedTcells(NF-ATc)isacrucialtransducerofcellularfunction.NF-ATcisanubiquitoustranscriptionfactorbuthasparticularrelevanceincytokineexpressionandthedevelopmentofpathologicmyocardialhypertrphy.

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