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Diastereoselective Synthesis of Pronucleotides Explained

The present invention is directed to a process for the diastereoselective synthesis of phosphorus compounds, particularly pronucleotides (nucleotide prodrugs). Pronucleotides represent a promising alternative to improve the biological activity of nucleoside analogs in antiviral and cancer chemotherapy.

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TuTech Innovation GmbH (TuTech)
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Astrid Stichnoth, Dr. Stefanie Klingelhöfer, Karl-Heinz Rehfeldt, Ingo Siebert

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