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Metformin’s Role in Treating Multiple Sclerosis and GvHD

Metformin prevents the production of reactive oxygen species (ROS) of mitochondrial complex I. Consequently the expression of CD95 (Fas) ligand is blocked leading to the inhibition of activation-induced T-cell death (AICD). Thus undesirable T-cell death can be inhibited by metformin. Therefore metformin can be used for the treatment of T-cell mediated inflammatory diseases like multiple sclerosis and graft-versus-host disease.

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DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
Phone: +49-6221-42 2955

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Dr. Ruth Herzog

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