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New Membrane Valve Mechanism Enhances Organ Transplant Outcomes
In transplantation, the acute event of ischemia-reperfusion is associated with considerable inflammation and edema in the allograft. This leads to edemarelated increase in tissue pressure resulting in microcirculatory impairment and tissue damage. Increased tissue pressure plays an important pathophysiological role that further aggravates organ damage and prevents regenerative processes. As a consequence, potentially effective therapies cannot exert their beneficial effects.
In a preclinical model, the decompressive treatment by incision of the kidney capsule was shown to cause pressure relief and enable functional recovery and significantly improve kidney function following renal ischemia-reperfusion injury. It was also shown that pressure relief by decompression therapy is required to exploit the beneficial effects of cell therapy for enhanced longterm outcome. As decompressive treatment leads to improved blood flow, the delivery of protective agents and immunosuppressives to the sites of action is be facilitated. This results not only in enhanced efficacy, but also in a dose reduction of immunosuppressive drugs and a lower adverse effects profile. In regard to the application in humans, the closure of the incision site using a membrane with a valve mechanism is pivotal in order to minimize the risk of complications.
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