Technology Offerings

KERatin – 3D artificial skin models for therapy strategies of keratinisation disorders

Technology Offerings

The present invention describes a 3D model mimicking normal skin. The model shows the following advantages:

– a collagen-fibroblast matrix and a fully stratified and cornified epidermal layer of primary human keratinocytes – epidermal basal layer and terminal differentiation can be seen – barrier function is present (normal skin) or reduced (disease model) – able to mimic single gene caused keratinisation disorders, e.g. congenital ichthyosis Challenge Since European and national regulations restrict the use of animals for the production and development of cosmetic products, adequate skin models are required. Pharmacological and pharmaceutical studies are presently done in 2D cell cultures, rodents and finally in humans. All these test systems either lack the genetic defect and disease phenotype that the drug is intended to cure or have to be developed tediously. Pharmacological and medical outcomes are thereto only predictable, as drug metabolism, drug transfer, e. g. through the epidermis, drug effect (in skin with missing gene products) cannot be foreseen.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

Comments (0)

Write a comment

Most Read Articles

Feeding 9 Billion: Innovations in Agricultural Modeling
Genetic Factors Behind Black-White-East Asian IQ Differences
This infrared image from NASA’s James Webb Space Telescope was taken by the onboard Near-Infrared Camera for the JWST Advanced Deep Extragalactic Survey, or JADES, program. The NIRCam data was used to determine which galaxies to study further with spectroscopic observations. One such galaxy, JADES-GS-z14-0 (shown in the pullout), was determined to be at a redshift of 14.3, making it the current record-holder for most distant known galaxy. This corresponds to a time less than 300 million years after the big bang. Image Credit: NASA, ESA, CSA, STScI, Brant Robertson (UC Santa Cruz), Ben Johnson (CfA), Sandro Tacchella (Cambridge), Marcia Rieke (University of Arizona), Daniel Eisenstein (CfA), Phill Cargile (CfA)
Webb Telescope Finds Oldest Galaxy Ever: JADES-GS-z14-0!
For a century, astronomers have been studyingBarnard’s Starin the hope of finding planets around it. First discovered by E. E. Barnard atYerkes Observatoryin 1916, it is the nearest single star system to Earth. Now, using in part theGemini North telescope, one half of theInternational Gemini Observatory, partly funded by the U.S. National Science Foundation and operated by NSF NOIRLab, astronomers have discovered four sub-Earth exoplanets orbiting the star. One of the planets is the least massive exoplanet ever discovered using the radial velocity technique, indicating a new benchmark for discovering smaller planets around nearby stars. Image Credit: International Gemini Observatory/NOIRLab/NSF/AURA/P. Marenfeld
New Planetary System Discovered Around Nearest Star
Closeup shot of a flock of butterfly on the ground. Image by wirestock, Envato
Butterflies Choose Mates Based on Attractiveness Factors
The researchers. Image Credit: King's College London
New Antibody Reduces Tumor Growth in Resistant Cancers