A new embodiment of a braiding machine was developed at the Institute of Aircraft Design (IFB) of Stuttgart University. It features a thread positioning unit which forms a secondary ring of horn-gears close to the braiding point. This secondary ring moves synchronously with the primary horn-gears of the braiding machine. Therefore, the position of each thread, that is close to the mandrel, is clearly defined. This is a basic requirement for manipulation of specific threads during the braiding process, which in turn permits the automated production of components with highly varying diameters at a constant braid angle.

Atoms can lose many of their electrons at very high temperatures, forming highly-charged ions (HCIs). Such HCIs constitute a large class of atomic systems…

Identifying liquid water is crucial in the search for habitable worlds beyond Earth and for the search of life as we know it.

The agonistic prodrug Fingolimod (FTY720) en-abled the first oral treatment of relapsing-remitting multiple sclerosis by modulating sphin-golipid signaling. Scientists developed novel Fingolimod non-prodrug derivatives, which re-duce the blood-brain-barrier leakage and blood T lymphocytes. Advantageously one derivative is fully active in the absence of sphingosine ki-nase 2 while exhibiting comparable activity to Fingolimod.

Scientists from Goethe University Frankfurt developed a new mobile device to determine ad-hoc coagulation times from full-blood samples utilizing “surface acoustic waves”. This coagulation time is of high importance e.g. during emergency situations when the coagulation status of a patient under anticoagulant therapy needs rapid evaluation.

All you need is basic musical knowledge, your instrument, and a mobile device. With several entertaining lessons, you will learn to improvise and improve your…

The sun emitted a significant solar flare, peaking at 12:22 p.m. EDT on March 11, 2015.

During the freezing of water, the initially unordered molecules start to form an ordered crystal, namely ice. During this phase transition, they rearrange from…

Moguntinones, a class of small molecule compounds comprise 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives with tumor and vascular targeting properties. The present invention relates to the use of Moguntinones for treatment of colorectal or gastric adenocarcinoma.

Tumor growth and metastasis are highly associated with the overexpression of protein kinases. Therefore protein kinases are an interesting class of target molecules for improved therapeutic attempts. These proteins are known to regulate the majority of cellular pathways including such relevant for control cell growth, movement and death – all processes relevant for cancer growth and progression.

A physiological process focused on in development of anti-cancer agents is apoptosis, a controlled form of cell death eliminating damaged, aberrant, infected, old or superfluous cells. In particular often mucosa tissue such as gastrointestinal mucosa is characterized by a rapid epithelial cell turnover in which homeostasis is maintained predominantly by apoptosis.

One essential prerequisite for growth and metastasis of cancers which form tumors is angiogenesis, a process involving the formation of new blood vessels from pre-existing capillary endothelial cells. Tumor cells may enhance angiogenesis by overexpression of proangiogenic factors, e.g. VEGF or interleukins. In general, this is especially pronounced with tumors having a high microvessel density as well as a particular aggressive behavior and high tendency to metastasize. Therefore, inhibitors of angiogenesis are researched as antitumor agents.

[Ref. UMZ252]

The inventive method allows the context-sensitive indexing of hemodynamic parameters. For the indexation of hemodynamic and biochemical parameters a more specific adjustment based also on non-biometric data can be used to more accurately assess and easily access the parameters and thus simplify and improve the care of critically ill patients.

NASA's Solar Dynamics Observatory captured images of the flares, which were classified as an M5.8-class and an M5.1-class, respectively.

As urban populations increase, so too does the complexity involved in maintaining basic services like clean water and emergency services. But one of the…

Because these young clusters contain very hot stars that generate energetic, intense Ultraviolet radiation, such dust disks, the sites of planet formation…

Recently, by combining the highly sensitive receiving capabilities of the National Science Foundation's (NSF) Green Bank Telescope (GBT) and the powerful radar…

Gravitational waves are generated when masses accelerate. The first indirect evidence for their existence was detected in 1974 when the binary pulsar PSR…

A team of astronomy researchers from Stony Brook University, the National Astronomical Observatory of Japan, and Tsuru University are the first to reveal clear…