New study reveals how human astroviruses bind to humans cells and paves the way for new therapies and vaccines Human astroviruses are a leading viral cause of the stomach bug—think vomiting, diarrhea, and fever. It often impacts young children and older adults, leading to vicious cycles of sickness and malnutrition, particularly for those in low and middle income countries. It’s very commonly found in wastewater studies, meaning it’s frequently circulating in communities. As of now, there are no vaccines for…
Army ants team little with large to lift heavy loads.
If you can’t see the point of the miniature back wheel on a penny-farthing bicycle, try riding a unicycle or watch an ant colony. Ants have realized that, to carry a heavy load, two supports are better than one – even if they seem comically mismatched.
When army ants partner up to carry a lump of food too big for a single ant to transport, an unusually large worker ant takes the front, and an unusually small one, the back
Draft Fugu genome will help find human genes.
A draft sequence of the puffer-fish genome is complete. The fishs compact genetics should accelerate the discovery of human genes and their key controlling sequences.
Gene-prediction programs struggle to find genes in the 3 billion letters of the human sequence, which includes swathes of junk DNA and defunct pseudogenes.
The bony fish Fugu rubripes shares our gene repertoire but has a genome one-eighth of the size.
Ancient embalming not to be sniffed at.
Archaeologists thought they had mummification wrapped up. But a new analysis of ancient Egyptian embalming suggests that they have underestimated this sophisticated funerary practice.
Pharaonic undertakers used a wealth of oils, waxes and fats, say Stephen Buckley and Richard Evershed at the University of Bristol, UK. They are the first to study several mummies from different periods using modern analytical chemistry 1
Bugs behind typhoid and food poisoning give up genetic secrets.
Two teams have sequenced the genomes of two Salmonella bacteria. One is responsible for typhoid; the other causes food poisoning.
The genomes should lead to new ways to diagnose, treat and vaccinate against both diseases. Comparing the sequences should also clarify why the closely related bugs behave quite differently.
The two strains are called Typhi and Typhimurium. Typhi, the typhoid bug, infects onl
Recent events have confirmed that bioterrorism is no longer a threat but a reality. To provide wide-ranging access to the latest scientific information about anthrax and other potential bioweapons, Nature has put together a special online focus on this issue. This focus includes the pre-publication* of two research papers on anthrax toxin, as well as a collection of research, news and feature articles from our electronic archive. Because of the heightened interest in this area, among both the scient
Genetic engineering gives us the fluorescent daisy.
It’s produced in Italy and guaranteed to make the face of that special someone light up. It’s the luminous bouquet. Under ultraviolet light the apparently normal blooms glow an unearthly green.
“The fluorescent flowers show that genetic engineering can be developed just for beauty,” says their developer, Tito Schiva of the Experimental Institute of Floriculture, San Remo. The technique should work for any white flower, Sch
Researchers find two new leads for anti-anthrax drugs.
As fears over bioterrorism attacks spiral, researchers are making progress towards better anthrax drugs – but these are unlikely to reach the drugstore soon.
Of ten confirmed anthrax cases in the United States by Monday, four have been of the severe, inhaled form against which antibiotics often fail. By the time drugs destroy the bacteria responsible, Bacillus anthracis, the organisms have released enough lethal toxin t
The gold-loving king’s rich diet may have hastened his decay.
Legend says that lust for gold was the cause of King Midas’ downfall. But his appetite for meat may have destroyed the final monument to his greatness 1 .
A mound excavated 44 years ago in Turkey is thought to be the resting place of the eighth-century BC ruler of Phrygia. The large tomb, although built of durable cedar wood, is in surprisingly bad shape, says geophysicist Timothy Filley of the Car
Researchers discover two molecules that help fruitflies sleep.
Mutant flies that lack the chemicals sleep more. In mammals the same molecules are also involved in learning and memory, supporting the idea that one function of sleep is to consolidate our record of the days experiences 1 .
The molecules are cyclic AMP and CREB, chemical messengers that work within cells. Cyclic AMP activates CREB, which then switches on genes.
Joan Hendricks, of th
Two techniques may help deduce proteins’ functions.
Imagine trying to guess what machines do just be looking at them. Even a can-opener would pose problems, if you didn’t know about cans. This is the challenge that faces molecular biologists as they try to make sense of protein molecules in the cell.
Two new techniques may help. One deduces a protein’s function from its shape; the other deduces its shape from a list of component parts 1 , 2 .
ATTO-TEC® has developed the second generation of fluorescent dyes which are stable at room temperature for more than six months.
With Atto 520, Atto 565 and Atto 590 we are pleased to offer three stable fluorescent dyes as amine-reactive succinimidyl esters which will be available from November 2001 on. This allows researchers an easy handling for selectively target- labeling by linking a fluorophore to primary amine groups on proteins or modified nucleic acids.
Further stable activate
Study questions whether mammography saves lives.
Breast-cancer screening programmes may not save lives, according to a new examination of clinical trials. The controversial findings have led to calls for a re-evaluation of the routine monitoring procedure undergone by numerous women.
Mammography, X-ray breast imaging, is used in Europe and the United States to catch cancers early. “We’ve based a national screening programme on a set of results which do not stand up to scrut
A large, long-term study confirms that diet can help some epileptic children.
A strict high-fat, low-carbohydrate, calorie-restricted diet reduces seizures in children with intractable epilepsy. So concludes the largest and longest trial of an eating plan that was first suggested almost a century ago.
For about two years, epileptic youngsters on a ’ketogenic diet’ eat 25% less than normal and consume 90% of their daily calories as fats. They take vitamins and minerals to avo
Chemists build molecules by paring them down
Complex molecules, such as many drugs, can be fiddly to assemble. By binding their starting compounds in chains 1 , chemists in Denmark may have found a way speed the automated chemical synthesis of such complicated products.
Les Miranda and Morten Meldal of Carlsberg University in Copenhagen have solved the following problem. Complex molecules are usually built up from a core with several near-identical hooks on w
About half of all patients with hereditary breast or ovarian cancer have mutations in a gene called BRCA1. Now the first images of the protein the gene encodes, BRCA1, are helping researchers work out how the mutations cause human disease.
The pictures reveal fine detail of how BRCA1 interacts with other proteins. Such information should help researchers work out how BRCA1 prevents cells becoming cancerous. They suspect that it is involved in DNA repair, controlling cell division and regula
Chameleons can reel in prey anywhere within two-and-a-half body lengths of their jaws. Their tongues can overcome even a bird’s weight and reluctance to be eaten. How? Muscles that are unique among backboned animals, researchers now reveal.
Anthony Herrel of the University of Antwerp, Belgium, and colleagues put crickets at different distances from the noses of two chameleon species, Chameleo calyptratus and Chameleo oustaletti. The tongues of these 12-cm-long reptiles pull at maximum stren