American Society for Cell Biology Meeting, Washington, December 2001

Microscope captures mitochondria bopping to a beat.

An intricate mesh of tubes wiggle, worm-like across the screen. “They’re speeding,” says Tim Richardson proudly, watching mitochondria, the cell’s energy generators, zoom around the cell. His controversial microscopic method is shooting the cell’s innards as they’ve never been seen before.

Live cell imaging has revolutionised cell biology over th

Vaccinations may increase death toll.

Inadequate vaccines can the encourage emergence of nastier bugs, placing the unprotected at risk, a new mathematical model shows. The effect could undermine future vaccination programmes.

Many vaccines save people from dying of a disease, but do not stop them carrying and transmitting it. Over a few decades this may cause more virulent strains to evolve, predict Andrew Read and his colleagues of the University of Edinburgh, UK 1

American Society for Cell Biology Meeting, Washington, December 2001

Stem cells’ fates are a multiple choice.

A single stem cell from adult mouse muscle can form enough blood cells to save another animal’s life – and still switch back to making brawn, researchers announced at the Washington meeting of the American Society for Cell Biology this week.

Stem cells found in mashed up muscle can migrate into the bone marrow and make blood cells 1 . Muscle

Bacteria give skin cells their marching orders.

Bacteria that cause potentially lethal ’flesh-eating’ infections make their entrance by telling skin cells to step aside. The bugs hijack the body’s signal for skin cells to become mobile.

Group A streptococci (GAS) normally infect the surface lining of the throat. But occasionally they penetrate skin or the tissues lining the airways, invading deep into the body and causing life-threatening disease.

Finding out how s

Scientists at the University of Pennsylvania have identified a receptor that plays a key role in restricting embryonic stem cells’ pluripotency, their ability to develop into virtually any of an adult animal’s cell types.
The work is the first demonstration of a mechanism by which pluripotency is lost in mammalian embryos, one that operates with nearly the precision of an on/off switch in mouse embryos.

With further study, the receptor, dubbed GCNF, could open the door to new ways of c

World’s smallest reptile is discovered in the Caribbean forest.

At just 16 mm from nose to tail, the Jaragua lizard is the world’s smallest. In fact, it’s the smallest vertebrate that can reproduce on dry land 1 .

The newly discovered lizard lives on Isla Beata, a small, forest-covered island in the Caribbean off the Dominican Republic. Blair Hedges, an evolutionary biologist at Pennsylvania State University, together with Richard Thomas of the

For more than 150 years, people around the world have made ample use of the explosive trinitrotoluene, otherwise known as TNT. Its use has had unintended consequences, however: the manufacture, storage and disposal of TNT—which ranks among the most toxic explosives employed by the military—have left large areas of land contaminated and polluted. So far, effective and affordable cleanup technologies have remained out of reach. But new research suggests that help may come from what might seem an unlike

Radon may pose a greater cancer threat than has been thought.

Radon damage from irradiated cells spreads to their neighbours, a new study finds 1 . The result suggests that small amounts of this radioactive gas could cause widespread harm.

The study “is a reason for concern but not panic”, says Gerhard Randers-Pehrson of Columbia University, New York, a member of the team that performed the study. “We’re talking about the acceptable level of radon changing pe

In news that will surely fan the flames of the heated debate over genetically modified crops, scientists have found evidence that genes from GM plants can spread far and wide to native ones. According to a report published today in the journal Nature, wild corn from the remote mountains of Oaxaca, Mexico contains transgenic DNA. This, the researchers note, bolsters concerns that such unintentional contamination can threaten the genetic diversity of natural crops.

DNA analyses of the Oaxaca

Generally speaking, we go to great lengths to rid our bodies of foreign bacteria, whether it’s by brushing our teeth, washing our hands or taking antibiotics. But new research suggests that when it comes to treating tumors, we may one day invite the bugs in. According to a study published yesterday in the early online edition of the Proceedings of the National Academy of Sciences, a bacterium that normally resides in soil, dust and dead flesh quickly destroys large tumors in mice when injected along

Rewiring the egg: mechanism remains murky.

From a scientific viewpoint, the cloning of human embryos may be more of a step than a leap, say sceptics. If the signals that turn adult cells into embryonic ones can be found, the creation of cloned embryos for tissue repair may become redundant.

Researchers at Advanced Cell Technology (ACT) in Worcester, Massachusetts, now report that they have created cloned human embryos. They aimed to make blastocysts, hollow balls of cells fr

The size and types of the largest local land animals vary greatly from place to place, prompting scientists to question what controls the success of animals of certain sizes over others. Now a report published in the current issue of the Proceedings of the National Academy of Sciences shows that the size of a landmass limits the maximal body size of its top animal.

Gary Burness and Jared Diamond of the University of California School of Medicine, together with Timothy Flannery of the South

New research is helping to unravel the machinery that allows a mosquito to sniff out its human quarry, which could lead to more and better ways of foiling the disease-spreading insects. A report published today in the online version of the Proceedings of the National Academy of Sciences describes four genes that appear to produce odor-sensing molecules in Africa’s Anopheles gambiae, a carrier of malaria, the number two killer in the developing world. Understanding how such genes operate could en

An immune system chemical may undo skin damage by sunlight.

A chemical involved in immune-system signalling may be able to reverse some types of skin damage caused by sunlight. It could reduce sunburn by activating DNA-repair mechanisms, a new study suggests, raising the possibility that the chemical might be used to prevent or treat skin cancer 1 .

High-energy ultraviolet light is thought to promote skin cancer by damaging the DNA within cells. Skin cancer,

Talk about multi-tasking. A new study reveals that in the St. John’s Wort plant, Hypericum calycinum, the same chemical not only attracts pollinating insects but also deters herbivores that pose a threat to its survival. The findings appear in the current issue of the Proceedings of the National Academy of Sciences.

To the human eye, the flowers of H. calycinum appear as uniform yellow disks (top image). Insects with ultraviolet-sensitive eyes, however, see a dark, ultraviolet-absorbing ce

While prion diseases seem to be waning in humans, they could be waxing in sheep.

Variant Creutzfeldt-Jakob disease (vCJD) may claim only around 200 victims, a new model predicts 1 . This degenerative brain disease is thought to occur when people are exposed to misfolded prion proteins from meat infected with bovine spongiform encephalopathy (BSE or ’mad cow disease’).

Meanwhile, another study warns that a huge BSE epidemic could be brewing in the UK