Researchers studying the Hedgehog signaling pathway have identified small molecules that could form the foundations of exciting new treatments for Parkinson’s disease and certain cancers.

New research published in Journal of Biology – the open access journal for exceptional research – has identified small molecules that are able to stimulate or block the Hedgehog signalling pathway, which is essential to the development, maintenance and repair of cells in the human body. The pot

Scientists at the Institute for Animal Health have revealed how a tropical bacterium is able invade cells, and ultimately trigger its escape using a homemade rocket. Their work is published in the November issue of Molecular Microbiology.

A group of scientists led by Dr Ed Galyov and Dr Mark Stevens have discovered that Burkholderia pseudomallei , which causes a disease called melioidosis, uses a special set of `effector` proteins to invade host cells. Their discovery has revealed surp

New research from investigators in the Centre for Neuroscience Studies at Queen’s University and the Centre for Brain and Mind at The University of Western Ontario has provided the first neuro-imaging evidence that the brain’s frontal lobes play a critical role in planning and choosing actions.

Their study is published today in the journal Nature Neuroscience.

The research team has found that a small region in the frontal lobe of the human brain is selectively activated when

Biologists at the Farber Institute for Neurosciences at Thomas Jefferson University have shown for the first time in the laboratory that they can convert some adult human neural stem cells to brain cells that can produce dopamine, the brain chemical missing in Parkinson’s disease. If the researchers can better understand the process and harness this ability, the work may someday lead to new strategies in treating neurodegenerative diseases such as Parkinson’s.

Developmental biologist L

A family history of breast cancer does not increase a woman`s chances of developing womb cancer, finds a 20-year study in the Journal of Medical Genetics.
Cancers of the lining of the womb (endometrium) and breast share some of the same reproductive, hormonal, and lifestyle risk factors. The evidence for a genetic link between the two types of cancer has so far been inconclusive.

But a team from the US National Cancer Institute and the Uniformed Services University of the Health Sciences

Will allow non-invasive study of neurochemistry, behavior, and disease progression

Scientists at the U.S. Department of Energy’s Brookhaven National Laboratory have demonstrated that a miniature positron emission tomography (PET) scanner, known as microPET, and the chemical markers used in traditional PET scanning are sensitive enough to pick up subtle differences in neurochemistry between known genetic variants of mice.

This “proof-of-principle” experiment, described i

T cells and antibody-producing B cells carry out immune defense against specific pathogens such as viruses. Antibodies and T cell receptors are highly diverse molecules that can recognize millions of different molecules. Upon encounter of a foreign antigen (such as a molecule from the surface of a virus), T cells and B cells whose receptors match that particular antigen expand dramatically, providing the immune system with a large number of very specific defenders. After an attack is fought off, the

Researchers are using a herpes virus that produces a firefly enzyme to illuminate the virus’s course of infection in mice and to help monitor the infection’s response to therapy. The work is published by scientists at Washington University School of Medicine in St. Louis in the December issue of the Journal of Virology.

“This study demonstrates the feasibility of monitoring microbial infections in living animals in real time,” says study leader David A. Leib, Ph.D., associate prof

A new technique enables doctors to directly examine the lining of milk ducts in the breast for early signs of cancer and other abnormalities, according to research at Washington University School of Medicine in St. Louis. The researchers used the technique, known as ductoscopy, to detect breast abnormalities in women with a condition called pathologic nipple discharge (PND).

The findings are published in the October issue of the journal Surgery.

“This technique is more successful

Indiana resident Luke Pascale runs two pizza restaurants and had worked out three times a week. He also enjoyed long bike rides with his wife, but last year, the pain in his hip became so severe he couldn’t stay on a bike for more than five minutes.

“I’m very active so the thought of having hip surgery was not pleasant,” said the 53-year-old father of four from St. John, Ind.

Instead of receiving the traditional hip replacement surgery, which uses a metal ball bearing in a polyeth

A group of researchers at The Scripps Research Institute (TSRI) have developed a novel DNA vaccine that helps the body resist the growth of cancerous tumors by choking off the tumors’ blood supply.

“We stimulate the immune system to recognize proliferating blood vessels in the tumor vasculature and to recruit killer T cells to destroy these vessels,” explains TSRI Immunology Professor Ralph Reisfeld, Ph.D., who conducted the study with Research Associate Andreas G. Niethammer, M.D., an

On Friday, November 8, Mats Hallman, Department of Odontology, Jaw Surgery, Umeå University in Sweden, will defend a thesis that presents favorable results from implanting bone powder from calves to anchor tooth implants in humans.

Tooth implants have long been a well-tested method to create permanent teeth in toothless sections of the jaw. In certain cases, however, patients have no bone in which to secure the titanium screws. In these cases it is necessary to rebuild the bone prior

Age is the ’equalizer,’ according to a study that provides new insights into why women live longer than men

Men die earlier than women. This fact leads scientists and medical researchers to conclude that gender and age are two basic factors continuously affecting body functions, disease categories and even life expectancy. Previous research has determined that gender influences brain structure and functions; however, in considering the cardiac pacemaker, there is still debat

Like farmers across the nation bringing in their crops this season, researchers in Wisconsin are carefully taking stock of a very special harvest – one grown aboard the International Space Station.

They’ve measured and weighed plants, counted seeds, and collected additional physical information from the first-ever soybean crop grown aboard the orbiting research laboratory.

Now, the research team will begin several months of chemical and biological tests on the plants that w

May increase susceptibility to inflammatory diseases such as allergic, autoimmune or cardiovascular diseases

Chronic stress not only makes people more vulnerable to catching illnesses but can also impair their immune system’s ability to respond to its own anti-inflammatory signals that are triggered by certain hormones, say researchers, possibly altering the course of an inflammatory disease. This finding is reported on in the November issue of Health Psychology, published by the

A group of researchers in Trondheim, Norway, are the first in the world to use in vivo magnetic resonance spectroscopy (MRS) to separate benign tumors from cancer. Ingrid Susann Gribbestad shows, in her recently published thesis, how one can discover breast cancer and monitor the treatment by using this new technology. The work is financed by the Norwegian Cancer Society and the Research Council of Norway.

www.kreft.no: The research behind this thesis was done at the Foundation