St. Jude scientists say FKHR protein causes primitive cells called myoblasts to fuse, while deficiency of FKHR contributes to muscle cancer

Investigators at St. Jude Children’s Research Hospital have discovered that a protein causing mature cells to commit suicide also helps primitive muscle cells called myoblasts fuse together, allowing them to develop into muscles. The finding of this unexpected new role for the protein, called FKHR, suggests that future research might offer cl

Animal behaviorists have something new to crow about.

Researchers at the University of Washington have found a species of crow that distinctly alters its behavior when attempting to steal food from another crow, depending on whether or not the other bird is a relative.

The Northwestern crow (Corvus caurinus) uses a passive strategy when it attempts to take food from kin but becomes aggressive when it tries to steal a morsel from a non-related crow. This is believed to be the

Tube worms living at deep-sea oil seeps in the Gulf of Mexico significantly alter their habitat, similar to beavers altering the flow of a river. Researchers from Pennsylvania State University have just published an important finding in the journal Ecology Letters.

A computer model of tube worm aggregations was created for Lamellibrachia luymesi, which is among the longest lived animals known. Both actual and model populations persist for centuries and take up high quantities of sulfide fro

Prospects for surviving acute liver failure are very slim, and statistics place mortality as high as 90 percent. A liver transplant may be the only alternative before fatal complications set in, yet not enough donor organs are available to meet the demand.

But a new bio-artificial technology about to undergo clinical tests at the University of North Carolina at Chapel Hill and several other centers nationally may help extend the lives of those awaiting a donor liver and may even allow the

Johns Hopkins researchers last year reported that an experimental treatment for severe ragweed allergy consisting of just six shots in six weeks dramatically reduced allergic symptoms such as runny nose, nasal congestion and sneezing, and nearly eliminated the need for relief medications like antihistamines and decongestants. Now, follow-up of patients who continued in the study for a second year, shows that the initial six-injection course of this treatment appears to be effective – and safe – for m

North Carolina State University poultry scientists have developed a powerful new tool to aid the understanding of how chicken embryos develop.

The research of Dr. Paul Mozdziak, assistant professor of poultry science, and Dr. James Petitte, professor of poultry science, resulted in successfully transferring a gene into a chicken and establishing a line of chickens carrying that specific marker gene.

Currently, the chick embryo is often used as a model to understand normal a

A lack of oxygen in waters around the world could be doing more than just suffocating fish: It may be acting as an endocrine disruptor and impeding their ability to reproduce, posing a serious threat to the survival of many populations.

A new study of carp suggests that hypoxia, or oxygen deficiency, is an endocrine disruptor. The findings add a surprising member to the growing list of potential hormone-disturbing agents — a list that includes pesticides such as atrazine and DDT, various typ

Mayo Clinic researchers have proven for the first time that cells produced by the bone marrow can form new heart-muscle cells in adults, providing an important boost to research that could enable the body to replace heart muscle damaged by heart attack. The findings are now available online and will be published tomorrow in Circulation: Journal of the American Heart Association.

“Until recently, the heart has been seen as an organ that cannot be healed,” says Noel Caplice, M.D., the Mayo Cli

Study shows life-threatening reactions from accidental ingestion can be avoided

A new medication could help most people with peanut allergies avoid life-threatening allergic reactions, according to a report in the March 14 issue of the New England Journal of Medicine. A research team led by Donald Leung, M.D., Ph.D. of National Jewish Medical and Research Center, and Hugh Sampson, M.D. of Mount Sinai School of Medicine, found that treatment with an anti-IgE antibody raised the average

Mayo Clinic has found that for patients with eye shingles, oral antiviral drugs are critical to prevent long-term consequences in the eye. Untreated, 10 percent of eye shingles patients experience a serious long-term outcome, such as severe visual loss, eyelid scarring or chronic in-turning of the eyelashes; if treated, two percent of patients experience these effects. The Mayo Clinic study refutes the findings of a previous British study of oral antivirals in patients with eye shingles.

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Genetically altered bacterial viruses appear to be more effective than naked DNA in eliciting an immune response and could be a new strategy for a next generation of vaccines that are easy to produce and store, say researchers from Moredun Research Institute in the United Kingdom.

“In theory, millions of doses can be grown within a matter of days using simple equipment, media and procedures,” says John March, one of lead researchers presenting findings at the American Society for Microbiol

Fndings in mice hold implications for human disorders

New research at the University of North Carolina at Chapel Hill offers an important contribution to a new wave of thinking in genetics: the idea that not all human disease states are due to alterations in DNA sequence.

A growing body of research on these “epigenetic” changes are leading geneticists to rethink the conventional view that all human disease is fundamentally tied to DNA sequence variation (changes in the actua

Studying mice, scientists from Johns Hopkins have successfully prevented a molecular event in brain cells that they’ve found is required for storing spatial memories. Unlike regular mice, the engineered rodents quickly forgot where to find a resting place in a pool of water, the researchers report in the March 7 issue of the journal Cell.

The experiments are believed to be the first to prove that subtly altering the chemistry of a certain protein can profoundly affect a brain cell&#146

Connections seen to X-linked mental retardation and some forms of leukemia

Most of the time, most of the estimated 35,000 genes in the human genome are silent, securely stored away in the tightly coiled structure of chromatin, which makes up chromosomes. Inside chromatin, the DNA is wound around small proteins called histones, making it unavailable to the cellular machinery that would otherwise read its coded genetic information. Specific cell and tissue types are characterized by the

Viral enzyme ’clear cuts’ forest of protective molecules on lung cells in mice; blocking that enzyme reduces illness and incidence of death from subsequent infection by Streptococcus pneumoniae

Investigators at St. Jude Children’s Research Hospital have shown in mice how the potentially deadly cooperation between influenza virus and bacterial pneumonia infections can be foiled, even if treatment is delayed and flu virus levels in the lung have peaked.

The St.

Exactly fifty years ago, Watson and Crick revealed the structure of DNA, unleashing a scientific revolution. On the anniversary of that momentous discovery, the world’s leading science journal, Nature, will publish new and groundbreaking genetic research by Bangor University scientist, Dr. Isabelle Colson. Isabelle is an expert in evolutionary biology, the study of how life evolves, and for 18 months she was an invaluable part of a Manchester-based team studying mutation in yeast – a seemingly simple