New data shows that the antiepileptic drug Keppra (levetiracetam), when used alone and in combination with other treatments, provided relief to more than 90 percent of patients with a range of pain syndromes, from migraine headaches to neck and back pain. The study of 400 patients, conducted by the Statesville Pain Associates of Statesville, N.C., was presented today at the American Pain Society’s 22nd Annual Scientific Meeting.

“To date, studies of Keppra to treat pain have been condu

In the developing brain, nerve cells make connections with one another by extending processes, often over long distances.

The growing tips of these nerve cell processes are guided to their ultimate connection sites by molecular cues in the environment.

A Salk Institute research team has discovered a receptor-protein interaction that guides nerve cells along specific pathways.

John Thomas, professor of molecular neurobiology, working on the fruit fly Drosophila, found tha

The delicate interplay of two chemical signals coaxes stem cells into becoming hair follicles, according to new research by scientists at the Howard Hughes Medical Institute at The Rockefeller University.

The research has implications for understanding hair growth and hair-follicle development, and it may also help explain how diverse structures, such as teeth and lungs, are formed or how some forms of skin cancer develop.

In an article published in the March 20, 2003, issue of the

The human body has barriers such as skin and the lining of airways and gut that protect and separate us from the outside world. If these barriers are breached, our survival is threatened. Therefore it is critical that the cells that form these barriers have mechanisms that can instantly repair any injury.

University of Iowa researchers have discovered a surprisingly simple but effective repair system in airway barrier cells. The UI study shows that by placing a messenger molecule on one side

Howard Hughes Medical Institute researchers and their colleagues have discovered one way in which the human immunodeficiency virus (HIV) wins its cat-and-mouse game with the body’s immune system.

The study, published in the March 20, 2003, issue of the journal Nature, shows that HIV-1, a common strain of the virus that causes AIDS, uses a strategy not seen before in other viruses to escape attack by antibodies, one of the immune system’s prime weapons against invading viruses and b

Research at Oxford University’s Institute of Molecular Medicine has identified a novel therapeutic regimen for the treatment of cancer that provides significant advantages over the existing methods of cancer treatment.

There are already a number of regimens available for treatment of cancer, including chemotherapy, which is commonly used to treat a number of different types of cancer. In most cases chemotherapeutic agents are given at the maximum tolerated dose (MTD), but at such doses the

New research shows that a more effective method of genetic engineering could be used to eradicate or manipulate entire, wild populations of harmful species rather than simply small, managed populations, as is currently the case. The research,* to be published in Proceedings B, a learned journal produced by the Royal Society, shows in computer simulations how a single, ’selfish’ gene could be used to infect the host and eliminate ’problem’ genes, for example a gene allowing mosquit

Discovery points to one possible path to novel drug development for cancer, AIDS, some inflammation

Using a new approach, Mayo Clinic researchers have successfully “taught” an RNA molecule inside a living cell to work as a decoy to divert the actions of the protein NF-kappaB, which scientists believe promotes disease development. The findings are published in the current issue of Proceedings of the National Academy of Sciences.

Although it also plays helpful roles in the bod

Johns Hopkins scientists have discovered that primitive human embryonic stem (ES) cells, temperamental in the lab, can be grown with the help of special cells from bone marrow, offering an easily obtained and well-studied source of human cells to nurture the human ES cells as they divide.

First announced in 1998, human embryonic stem cells are usually grown in the lab on a “feeder layer” of mouse cells. Feeder cells send as yet unknown signals to the primitive human ES cells, preventing the

The popular stimulant blocks adenosine receptors, and is the most likely mechanism of central nervous actions that delay exercise-related fatigue, a new study finds

Consuming caffeine, whether in coffee of soft drinks, has been shown to delay fatigue during prolonged exercise. Studies have shown, for example, that ingesting three to nine mg/kg of caffeine can increase the amount of exercise time to achieve by as much as 50 percent. How caffeine achieves this effect has not been ful

Proteins, it appears, have taken Frank Sinatra’s “I Did It My Way” close to heart. A new study published in the current issue of Proceedings of the National Academy of Sciences (PNAS) reveals how single proteins, each a few nanometers (billionths of a meter) long, fold to assume their final shape. It shows that even proteins having the same final shape achieve it by taking different routes.

Proteins are the fundamental components of all living cells. They start out as randomly shaped c

In at least one type of endeavor, humans can’t even begin to compete with their best friends. Dogs can be trained to sniff out drugs and explosives or to track down a crime suspect by smell. Why can’t we do the same? Scientists from the Weizmann Institute of Science and the Max Planck Institute for Evolutionary Anthropology propose an explanation for this ancient quandary.

All mammals, including humans, have about 1,000 genes encoding smell-detecting proteins, or olfactory recepto

A team of scientists from Cambridge University and Bristol University, led by Dr Naomi Langmore of the Australian National University, has found that some Australian birds are one step ahead of their British counterparts in their ability to avoid being victimized by cuckoos.

Cuckoos exploit other bird species by laying their eggs in the nests of other birds. Soon after hatching, the cuckoo chick kills host young by tipping them out of the nest. The foster parents then work hard to rear the i

Anxiety has long been linked to substance abuse. It is the key psychological factor driving the impulse to drink alcohol and one of the first symptoms of alcohol withdrawal.

Now, researchers at the University of Illinois at Chicago have discovered they can control the urge to drink in experimental animals by manipulating the molecular events in the brain that underlie anxiety.

The study is published in the current issue of Alcoholism: Clinical and Experimental Research, the nation

New study may have implications for millions in search of the elusive “good night’s sleep”

In movies and novels alike, much is made of the stage of sleep known as rapid eye movement (REM), since this is the phase of slumber in which dreams (good, bad, exotic) occur. Among the medical community, there is an increased appreciation for what is called “slow-wave” sleep, (also known as deep or delta-wave sleep), because this fourth stage of sleep can be difficult to attain. If one is aw

Study Sheds light on HIV mutation process; May help guide AIDS vaccine development

Scientists in California have provided the first detailed look at how human antibodies, proteins critical for the body’s defense against invading pathogens, may actually drive human immunodeficiency virus (HIV) to mutate and escape detection by the immune system. The findings, reported online March 18 in the Proceedings of the National Academy of Sciences, may be key in efforts to develop an effective