Endoscopes made of single-hair thin optical fibers can reconstruct images of macroscopic objects at larger imaging distances. Scientists are developing tools to observe the biological machinery in in vivo animal models to be able to understand and better treat severe brain diseases like Alzheimer’s disease and many other conditions. Holographic endoscopes attracted researchers’ interest because of their potential to conduct minimally invasive observations inside the human body. These tools can shed light on the biological processes occurring at the macromolecular…

The protein Asc-1 regulates whether fat-burning beige or fat-storing white adipocytes are formed, which can have an impact on the development of metabolic diseases. This is shown by a current study of the Helmholtz Zentrum München and the German Center for Diabetes Research (DZD). The results open up new approaches to prevent the development of metabolic diseases. The study has now been published in Nature Communications. Not all fat is the same: there is white, brown and beige adipose tissue…

Technology project with Heidelberg participation wants to develop compact cell-imaging for extensive application. Advancing research into how viruses penetrate and act on human cells requires powerful cell imaging approaches. Soft X-ray microscopy is particularly suitable but has so far not been widely available. A pan-European research project called “Compact Cell-Imaging Device” with Heidelberg participation seeks to develop this technology for extensive application in medical research. How do viral pathogens succeed in penetrating human cells? Which cellular mechanisms do they use…

Washington State University researchers have discovered a protein that could be key to blocking the most common bacterial cause of human food poisoning in the United States. Chances are, if you’ve eaten undercooked poultry or cross contaminated food by washing raw chicken, you may be familiar with the food-borne pathogen. “Many people that get sick think, ‘oh, that’s probably Salmonella,’ but it is even more likely it’s Campylobacter,” said Nick Negretti (’20 Ph.D.), a lead member of the research team…

NIAID research suggests protective effects of vaccination remain intact. WHAT: When variants of SARS-CoV-2 (the virus that causes COVID-19) emerged in late 2020, concern arose that they might elude protective immune responses generated by prior infection or vaccination, potentially making re-infection more likely or vaccination less effective. To investigate this possibility, researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and colleagues analyzed blood cell samples from 30 people who had…

Scientists find evidence that antibody-based treatments in clinical trials for neurodegenerative diseases may trigger an inflammatory response in human brain immune cells, eroding their positive effects. A team led by scientists at Scripps Research has made a discovery suggesting that experimental antibody therapies for Parkinson’s and Alzheimer’s have an unintended adverse effect–brain inflammation–that may have to be countered if these treatments are to work as intended. Experimental antibody treatments for Parkinson’s target abnormal clumps of the protein alpha-synuclein, while experimental…

A team led by investigators at Weill Cornell Medicine and NewYork-Presbyterian has used advanced technology and analytics to map, at single-cell resolution, the cellular landscape of diseased lung tissue in severe COVID-19 and other infectious lung diseases. In the study, published online March 29 in Nature, the researchers imaged autopsied lung tissue in a way that simultaneously highlighted dozens of molecular markers on cells. Analyzing these data using novel analytical tools revealed new insights into the causes of damage in…

For people with tooth decay, drinking a cold beverage can be agony. “It’s a unique kind of pain,” says David Clapham, vice president and chief scientific officer of the Howard Hughes Medical Institute (HHMI). “It’s just excruciating.” Now, he and an international team of scientists have figured out how teeth sense the cold and pinpointed the molecular and cellular players involved. In both mice and humans, tooth cells called odontoblasts contain cold-sensitive proteins that detect temperature drops, the team reports…

Scientists at St. Jude are studying how signals sent from skeletal muscle affect the brain. How do different parts of the body communicate? Scientists at St. Jude are studying how signals sent from skeletal muscle affect the brain. The team studied fruit flies and cutting-edge brain cell models called organoids. They focused on the signals muscles send when stressed. The researchers found that stress signals rely on an enzyme called Amyrel amylase and its product, the disaccharide maltose. The scientists…

During drought, plants use a signalling molecule known from animals to limit their water loss. The molecule provides them with a kind of memory of how dry the day was. “I‘ve been studying how plants regulate their water balance for over 35 years. To find a completely new and unexpected way for saving water has certainly been one of the most surprising discoveries in my life.” So says Professor Rainer Hedrich, plant scientist and biophysicist from Julius-Maximilians-Universität (JMU) Würzburg in…

NIH labs collaborate to develop new methods for studying genome-wide DNA damage and repair. Researchers at the National Institutes of Health (NIH) have discovered specific regions within the DNA of neurons that accumulate a certain type of damage (called single-strand breaks or SSBs). This accumulation of SSBs appears to be unique to neurons, and it challenges what is generally understood about the cause of DNA damage and its potential implications in neurodegenerative diseases. Because neurons require considerable amounts of oxygen…

New technology enables ultrafast identification of COVID-19 biomarkers. Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes. It is faster and cheaper than a conventional blood count. To demonstrate the technique’s potential, the researchers used blood plasma collected from COVID-19 patients. Using the new technology, they identified eleven previously unknown proteins which are markers of disease severity. The work…

When the brain suffers injury or infection, glial cells surrounding the affected site act to preserve the brain’s sensitive nerve cells and prevent excessive damage. A team of researchers from Charité – Universitätsmedizin Berlin have been able to demonstrate the important role played by the reorganization of the structural and membrane elements of glial cells. The researchers’ findings, which have been published in Nature Communications*, shed light on a new neuroprotective mechanism which the brain could use to actively control…

A German-American research team has succeeded in converting flat nitrogen-containing molecules into three-dimensional structures. These now significantly expand the range of molecules that chemists can draw on in their search for new active ingredients. A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates exhibit a variety of improved properties compared to predominantly flat molecular structures, which are reflected in clinical trials…

Scientists at the University of Bonn and the caesar research center have isolated a molecule that might open new avenues in the fight against SARS coronavirus 2. The active ingredient binds to the spike protein that the virus uses to dock to the cells it infects. This prevents them from entering the respective cell, at least in the case of model viruses. It appears to do this by using a different mechanism than previously known inhibitors. The researchers therefore suspect…

For the first time, researchers from the SponGES project collected year-round video footage and hydrodynamic data from the mysterious world of a deep-sea sponge ground in the Arctic. Deep-sea sponge grounds are often compared to the rich ecosystems of coral reefs and form true oases. In a world where all light has disappeared and without obvious food sources, they provide a habitat for other invertebrates and a refuge for fish in the otherwise barren landscape. It is still puzzling how…