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Health & Medicine
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New Insights Into Targeting Stomach Bug Virus Treatment

New study reveals how human astroviruses bind to humans cells and paves the way for new therapies and vaccines Human astroviruses are a leading viral cause of the stomach bug—think vomiting, diarrhea, and fever. It often impacts young children and older adults, leading to vicious cycles of sickness and malnutrition, particularly for those in low and middle income countries. It’s very commonly found in wastewater studies, meaning it’s frequently circulating in communities. As of now, there are no vaccines for…

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Life & Chemistry

Cellulose Fibers: A Sustainable Solution for Climate Change

Protecting the global climate is an undertaking that presents both industry and society with a major task. It will not be possible to achieve the climate targets simply by limiting global emissions, by saving carbon dioxide (CO2). This is because there will continue to be unavoidable CO2 emissions that will nevertheless have to be compensated. Ways out of this unfortunate situation can be measures such as reforestation, carbon sequestration in the soil or even the active capture of CO2 from…

Life & Chemistry

New Perovskite Catalyst Reduces CO2 Emissions Effectively

Which catalyst can be used to convert carbon dioxide into other substances? Scientists at TU Wien have now created a new material, which belongs to the class of perovskites. If the CO2 content of the atmosphere is not to increase any further, carbon dioxide must be converted into something else. However, as CO2 is a very stable molecule, this can only be done with the help of special catalysts. The main problem with such catalysts has so far been their…

Medical Engineering

Tiny Implant Tool Enhances Brain Activity Imaging

Researchers used nanophotonic technology to develop a brain-implantable tool that can aid in the optical imaging of brain activity. Tools that allow neuroscientists to record and quantify functional activity within the living brain are in great demand. Traditionally, researchers have used techniques such as functional magnetic resonance imaging, but this method cannot record neural activity with high spatial resolution or in moving subjects. In recent years, a technology called optogenetics has shown considerable success in recording neural activity from animals…

Health & Medicine

MK-4482 Antiviral Shows Promise Against COVID-19 in Hamsters

MK-4482 shows potential to prevent and treat SARS-CoV-2 infection. The experimental antiviral drug MK-4482 significantly decreased levels of virus and disease damage in the lungs of hamsters treated for SARS-CoV-2 infection, according to a new study from National Institutes of Health scientists. SARS-CoV-2 is the virus that causes COVID-19. MK-4482, delivered orally, is now in human clinical trials. Remdesivir, an antiviral drug already approved by the U.S. Food and Drug Administration for use against COVID-19, must be provided intravenously, making…

Life & Chemistry

Neural Plasticity: Long Noncoding RNA’s Role in Memory Formation

Making memories involves more than seeing friends or taking photos. The brain constantly adapts to new information and stores memories by building connections among neurons, called synapses. How neurons do this–reaching out arm-like dendrites to communicate with other neurons–requires a ballet of genes, signaling molecules, cellular scaffolding and protein-building machinery. A new study from scientists at Scripps Research and the Max Planck Florida Institute for Neuroscience finds a central role for one signaling molecule, a long, noncoding RNA that the…

Life & Chemistry

Plants and Pollinators: Key Anchors of Healthy Ecosystems

The next time you go for a hike, take an extra moment to appreciate the seemingly ordinary life all around you. A house fly, humble yarrow weed and other “generalist” plants and pollinators play a crucial role in maintaining biodiversity and may also serve as buffers against some impacts of climate change, finds new University of Colorado Boulder research. The findings, published this month in Ecology, provide valuable insights for prioritizing the conservation of species that contribute to the strength…

Health & Medicine

Scientists Discover Human Genes That Combat COVID-19 Infection

Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers’ understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the body’s frontline virus fighters. The study was published in the journal Molecular Cell. “We wanted to gain a better understanding of the cellular response to SARS-CoV-2,…

Life & Chemistry

Designing Smarter Antibody Drugs Using Artificial Intelligence

Antibodies are not only produced by our immune cells to fight viruses and other pathogens in the body. For a few decades now, medicine has also been using antibodies produced by biotechnology as drugs. This is because antibodies are extremely good at binding specifically to molecular structures according to the lock-and-key principle. Their use ranges from oncology to the treatment of autoimmune diseases and neurodegenerative conditions. However, developing such antibody drugs is anything but simple. The basic requirement is for…

Life & Chemistry

Triangular Spikes: Key to Understanding COVID-19 Transmission

COVID-19 needs no introduction. Last year, the disease, which is caused by the virus SARS-CoV-2, reached every continent across the globe. By the end of March 2021, there had been an estimated 128 million cases recorded with almost three million of these being fatal. As scientists’ race to develop vaccines and politicians coordinate their distribution, fundamental research on what makes this virus so successful is also being carried out. Within the Mathematics, Mechanics, and Materials Unit at the Okinawa Institute…

Life & Chemistry

Measuring Oxygen Levels in Rivers and Lakes Effectively

Wastewater carries large quantities of organic substances into the rivers and lakes, leading to heavy growth of bacteria and oxygen deficiency. Measurement methods have so far been incapable of measuring this organic pollution precisely. A new method co-developed by experts from the Helmholtz-Zentrum Hereon should provide a clear image of the water conditions in the future. The work has now been published in the scientific journal Science Advances. When wastewater from villages and cities flows into rivers and lakes, large…

Medical Engineering

Unlocking Intracellular Recordings with Novel Microelectrode

CMU/ITT researchers develop novel microelectrode platform to access and record intracellular activity. Behind every heartbeat and brain signal is a massive orchestra of electrical activity. While current electrophysiology observation techniques have been mostly limited to extracellular recordings, a forward-thinking group of researchers from Carnegie Mellon University and Istituto Italiano di Tecnologia has identified a flexible, low-cost, and biocompatible platform for enabling richer intracellular recordings. The group’s unique “across the ocean” partnership started two years ago at the Bioelectronics Winter School…

Life & Chemistry

Cells’ Size Detection: A Breakthrough in Basic Science

Lab study solves textbook problem … The answer to a basic science question could unlock the key to complex medical challenges. -Scientists have searched for years to understand how cells measure their size. Cell size is critical. It’s what regulates cell division in a growing organism. When the microscopic structures double in size, they divide. One cell turns into two. Two cells turn into four. The process repeats until an organism has enough cells. And then it stops. Or at…

Life & Chemistry

Exploring Bacteria’s Emergency Protein Channels for Survival

Almost all bacteria rely on the same emergency valves–protein channels that pop open under pressure, releasing a deluge of cell contents. It is a last-ditch effort, a failsafe that prevents bacteria from exploding and dying when stretched to the limit. If we understood how those protein channels worked, antibiotic drugs could be designed to open them on demand, draining a bacterium of its nutrients by exploiting a floodgate common to many species.  But these channels are tricky to operate in…

Life & Chemistry

Renewable Plant-Based Polymers: Easy to Recycle Innovations

What makes them different is that they can be easily recycled. Researchers at the Laboratory of Cluster Catalysis at St Petersburg University have synthesised polymers from biomass. What makes them different is that they can be easily recycled. Today, our life is simply unthinkable without polymers. Plastics, fibres, films, paint and lacquer coating – they are all polymers. We use them both in our everyday life and in industry. Yet the goods made from polymers, e.g. bottles, bags, or disposable…

Health & Medicine

3D Structure of Human Uterine Endometrium: New Insights

New insights into the three-dimensional (3D) morphology of the human uterine endometrium could advance our understanding of the mechanisms of endometrial regeneration and fertilized egg implantation while clarifying the pathogenesis of menstrual disorders, infertility and endometrium-related diseases such as adenomyosis, endometriosis, endometrial hyperplasia and endometrial cancer. The endometrial glands are comprised of complicated winding and branching structures, and conventional 2D imaging techniques have been unable to adequately assess their shape. This limitation has prevented elucidation of the mechanisms of endometrial…

Life & Chemistry

First Images Show COVID-19 Vaccine’s Native-Like Spikes

New research has for the first time compared images of the protein spikes that develop on the surface of cells exposed to the Oxford-AstraZeneca vaccine to the protein spike of the SARS-CoV-19 coronavirus. The images show that the spikes are highly similar to those of the virus and support the modified adenovirus used in the vaccine as a leading platform to combat COVID-19. The SARS-CoV-2 virus, which causes COVID-19, has a large number of spikes sticking out of its surface…

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