Heart disease associated with oral health – studies of women and serological factors

A new study from Karolinska Institutet in Sweden shows, for the first time, an association between coronary heart disease and oral health in women. Recent results have also shown that serological factors, might provide insight into the reported epidemiological association between periodontitis and cardiovascular disease.

Cardiovascular disease (CVD) is the leading cause of death in the Western industrialized world. Classic risk factors such as smoking, obesity and high blood lipids do not explain all clinical and epidemiological features of CVD. Chronic inflammation has been suggested as a possible “unknown” risk factor. However, the chronic inflammatory disease periodontitis, has only recently been found to be associated to CVD.

A new study from Karolinska Institutet shows, for the first time, an association between coronary heart disease (CHD) and oral health in women. A group of 187 female patients with CHD had fewer remaining teeth (P<0.001) and more pathological periodontal pockets (P=0.002) compared to a control group. Dentures were more frequent (27% vs. 6%) as was edentulousness (10.5% vs. 0%) in the CHD group compared to the controls. In another recent study from Karolinska Institutet risk factors for CVD were found in plasma from patients with periodontitis. Plasma levels of markers for arteriosclerosis and indices of inflammation in 50 patients with severe periodontitis were compared with those in 46 healthy cases. Total cholesterol levels were similar in the two groups, whereas levels of high density lipoproteins (HDL) were lower (P=0.007) and levels of C-reactive protein (CRP) were higher in the patient group. This is important, as both HDL and CRP are accepted risk factors for arteriosclerosis. Plasma levels of bacterial antigen specific IgA anti-Hsp60 antibodies were also lower in the patient group (P=0.0001). These serological differences might provide insight into the reported epidemiological association between periodontitis and CVD. A possible mechanism behind the reported association could be the release of bacteria, bacterial products or pro-inflammatory cytokines from the periodontal lesions into the blood stream.

Media Contact

Ulla Bredberg Rådén alfa

More Information:

http://www.ki.se

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Defects in quartz crystal structure reveal the origin of dust

University of Tübingen research team uses properties of quartz in sediments to study sedi-mentary cycles and climate dynamics. Global warming and a progressively drier climate in many parts of the…

Ultra-thin film creates vivid 3D images with large field of view

Glass-free technique could enable visual features that don’t require special reading devices or illumination. Researchers have developed a new ultra-thin film that can create detailed 3D images viewable under normal…

Artificial photosynthesis can produce food without sunshine

Scientists are developing artificial photosynthesis to help make food production more energy-efficient here on Earth, and one day possibly on Mars. Photosynthesis has evolved in plants for millions of years…

Partners & Sponsors