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Health & Medicine

Editorial urges ’black-box’ warning for Bextra and Celebrex

Physicians should avoid prescribing Bextra altogether, or use it only as a drug of last resort, says a researcher from Wake Forest University Baptist Medical Center and colleagues in an editorial published on-line Jan. 17 in Circulation, a publication of the American Heart Association.

Curt D. Furberg, M.D., Ph.D., professor of public health sciences, and colleagues describe an analysis of two studies revealed that patients treated with Bextra after heart bypass surgery tripled the

Studies and Analyses

CPR Quality Study: Insights on Hospital Guidelines Compliance

New technology has allowed researchers from the University of Chicago to measure, for the first time, how closely well-trained hospital staff comply with established guidelines for cardio-pulmonary resuscitation (CPR). The results reveal room for improvement.

In the 19 January 2005 issue of JAMA, the researchers show that, even in the hospital setting, chest compressions during CPR are often too slow, too shallow and too frequently interrupted, and ventilation rates are usually

Life & Chemistry

Managing GM Crops: Study Reveals Environmental Benefits

Proceedings of The Royal Society B: Biological Sciences

Management of genetically modified herbicide tolerant sugar beet for spring and autumn environmental benefit by Dr M May, Dr G Champion, Dr A Dewar, Dr A Qi and Dr J Pidgeon

This research provides conclusive evidence that environmental benefits can be obtained from GM herbicide tolerant (GMHT) sugar beet crops. Previous work, including the government’s Farm Scale Evaluation trials, suggested that GMHT sug

Health & Medicine

Simpler ’alphabet’ guidelines for treating acute coronary syndrome reduce risk

A simplified approach to the management of patients with an acute coronary syndrome (chest pain at rest or with mild exertion) can help ensure that precise risk-reducing strategies are followed to the letter by doctors and other caregivers of patients with this medical condition, according to a study by Johns Hopkins researchers.

“Many doctors think existing guidelines are lengthy and complex and therefore difficult to implement in the clinic and at home by patients,” says Roger S. Blumen

Health & Medicine

Collaborative Care Model Enhances Adolescent Depression Treatment

A model program featuring primary care physicians, nurses, and mental health providers working collaboratively to bring best-practice depression treatments into primary care clinics significantly improves health outcomes, quality of life, and depression care for adolescents (age 13-21), research team led by a UCLA investigator reports in the Jan 19, 2005, edition of the Journal of the American Medical Association.

After recent controversies about the safety and effectiveness of a

Health & Medicine

Ibogaine’s Impact on Brain Protein: A New Path to Reducing Alcohol Cravings

A naturally occurring hallucinogen advocated by some clinicians as a potent anti-addiction drug has been rigorously studied for the first time, confirming its ability to block alcohol craving in rodents, and clarifying how it works in the brain. The new research findings about the drug Ibogaine open the way for development of other drugs to reverse addiction without Ibogaine’s side effects, potentially adding to the small arsenal of drugs that effectively combat addiction.

D

Life & Chemistry

DNA Repair Deficiency Linked to Higher Breast Cancer Risk

Deficiencies in the ability of cells to repair damaged DNA are associated with an increased risk of breast cancer, according to a new study in the January 19 issue of the Journal of the National Cancer Institute.

DNA repair is the system of defenses designed to protect the integrity of the genome. Studies have suggested that deficiency in cells’ capacity for DNA repair contributes to the accumulation of DNA damage and accelerates the genetic changes involved in carcinogenes

Health & Medicine

Radiation Therapy Enhances Survival in High-Risk Breast Cancer

For patients with high-risk breast cancer treated with radical mastectomy and adjuvant chemotherapy, the addition of radiation therapy leads to better survival outcomes with few long-term toxic effects, according to a 20-year follow-up of a randomized trial, which appears in the January 19 issue of the Journal of the National Cancer Institute.

The British Columbia randomized radiation therapy trial was designed to determine the effect on survival of the addition of locoregional radiation

Health & Medicine

Fat Hormone Leptin: Key Brain Circuit in Obesity Control

New research published in the premier issue of Cell Metabolism finds that a single brain region is sufficient for normal control of blood sugar and activity level by the fat hormone leptin. The same region also exerts significant, though more modest, control over leptin’s effects on body weight. The findings in mice provide insight into potential mechanisms underlying type II diabetes and suggest new avenues for treatment, according to the researchers.

Secreted by fat cells, leptin

Physics & Astronomy

More of Titan’s secrets to be unveiled on 21 January

One week after the successful completion of Huygens’ mission to the atmosphere and surface of Titan, the largest and most mysterious moon of Saturn, the European Space Agency is bringing together some of the probe’s scientists to present and discuss the first results obtained from the data collected by the instruments.

After a 4000 million kilometre journey through the Solar System that lasted almost seven years, the Huygens probe plunged into the hazy atmosphere of Titan at 11

Physics & Astronomy

Huygens Probe Lands on Titan: A New Era in Space Exploration

Although Huygens landed on Titan’s surface on 14 January, activity at ESA’s European Space Operations Centre (ESOC) in Darmstadt, Germany, continues at a furious pace. Scientists are still working to refine the exact location of the probe’s landing site, seen above.

While Huygens rests frozen at -180 degrees Celsius on Titan’s landscape, a symbolic finale to the engineering and flight phase of this historic mission, scientists have taken little time off to eat or sleep. They have

Health & Medicine

Improving Behavior and Quality of Life in Children with Sleep Apnea

Behavioral and emotional difficulties are found in children with obstructive sleep apnea, but they improve after treatment, according to a study in the January issue of Archives of Otolaryngology – Head & Neck Surgery, one of the JAMA/Archives journals.

“Sleep-disordered breathing in children is most commonly caused by adenotonsillar hypertrophy [enlarged adenoids and tonsils], and tonsillectomy and adenoidectomy (T & A) is curative in 85 percent to 95 percent of cases,” according

Health & Medicine

Beneficial Effects of Low-Level Radiation on Small Mammals

Researchers of a study published in the latest issue of Environmental Toxicology and Chemistry tested the hypothesis that low doses of gamma radiation have beneficial effects. Researchers Rudy Boonstra, Richard G. Manzon, Steve Mihok, and Julie E. Helson found that low, chronic doses of gamma radiation produced apparent hormetic effects associated with an increase in longevity in natural populations of meadow voles.

Hormesis is defined as a phenomenon where low doses of an otherwise ha

Life & Chemistry

Australian Experts Unite to Tackle Deadly Virus Threats

Australian expertise is a crucial part of an international project aiming to develop therapies against two deadly viruses.

With funding from the United States’ National Institutes of Health (NIH), and in collaboration with a research team led by Dr Christopher Broder at the Uniformed Services University of the Health Sciences in Bethesda Maryland, CSIRO Livestock Industries’ Australian Animal Health Laboratory (AAHL) in Geelong is attempting to develop treatments against Hendra v

Environmental Conservation

Investigating Queenfish: A Study on Northern Australia’s Sportfish

The secret life of one of northern Australia’s most popular sportfish, the spectacular queenfish, is being studied by CSIRO scientists for clues to its role and abundance in the marine ecosystem.

The year-long study, co-funded by the National Oceans Office, is collecting more than 30 specimens a month from the Gulf of Carpentaria near Weipa where queenfish are caught by recreational anglers and inshore net fisheries. Results of the study will improve the ability of fisheries

Life & Chemistry

Subterranean Termites: A Growing Threat to Victoria’s Homes

Subterranean termites pose a major threat to dwellings and other vital infrastructure throughout Victoria according to a report released today by CSIRO Forestry and Forest Products (CFFP) scientist, Jim Creffield.

Mr Creffield says that in order to effectively manage the pest, all municipalities state-wide must immediately be ’termite declared’.

The report draws upon the expertise of the CSIRO Termite Group – comprised of ensis (a recently formed joint venture of CFFP and

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