TGF-ß has been shown to play an important
regulatory and protective role during lesion development in various central nervous system diseases.Further…
The introduction of foreign genes into early embryos is a powerful tool for developmental studies and for the production of transgenic animals.
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The invention relates to a process for reducing the number of mismatches in a population of double stranded polynucleotides.Further Information: PDF Fraunhofer…
TLR2 represents an “earliest possible” target for prevention and therapeutic
intervention in the pathogenesis of harmful immune reactions whose blockage…
It was surprisingly found that adenosine, if administered systemically not only
prior to ischemia but also in continuous infusion immediately after…
The new target named TEC1 is essential for the virulence of C. albicans. It suppresses the fungicidal functions of macrophages and is required for the evasion…
A multifunctional graft for use in vascular surgery: The principle is based on surface modification and drug elution out of a silicone coated polyester…
A new study of 60 beaches in Southern California suggests that water pollution varies with the lunar cycle, reaching the highest levels when tides are ebbing during the new and full moon. The findings could help beachgoers and managers better assess the potential risk of swimming.
The report appears in the Aug. 1 issue of the American Chemical Society’s journal Environmental Science & Technology. ACS is the world’s largest scientific society.
Coastal water q
Discovery may lead to new therapies for leukemia, other blood disorders
Researchers from the University of Pennsylvania School of Medicine found that a protein called NF-Ya activates several genes known to regulate the development of hematopoietic stem cells (HSC), or blood-producing stem cells, in bone marrow. Knowing the details of this pathway may one day lead to new treatments for such blood diseases as leukemia, as well as a better understanding of how HSCs work in the context
Dr. Norbert Perrimon and colleagues at Harvard Medical School (Boston, MA) have used a genome-wide RNAi screen in cultured Drosophila cells to identify novel regulators of the JAK/STAT signaling pathway.
In a stunning example of the utility of cell-based RNAi analysis in a genetically tractable system, like fruit flies, the researchers identified 121 genes involved in the JAK/STAT pathway, including a key, and previously unidentified, negative regulator of the pathway. PTP61F emerged fr
Inhibitors of cellular enzymes could be developed for SARS treatment
Researchers from the University of Pennsylvania School of Medicine have found that inhibitors of an enzyme called cathepsin L prevent the SARS (severe acute respiratory syndrome) virus from entering target cells. SARS is caused by an emergent coronavirus. There is no effective treatment at this time.
This study also demonstrates a new mechanism for how viral proteins are activated within host cells, sta
An international group of researchers has characterized the proteome of the human cornea. In doing so, they have identified 141 distinct proteins, 99 of which had not been previously recognized in mammalian corneas. The details of their findings appear in the August/September issue of Molecular and Cellular Proteomics, an American Society for Biochemistry and Molecular Biology journal.
The cornea is the transparent, dome-shaped window that covers the front of the eye. Although i
RoboLase technology may one day not only bridge laboratories but also allow physicians to perform medical procedures from distant locations
In an effort to combine sophisticated laser and Internet technologies, scientists in Australia have successfully performed laser surgery and “optical trapping” in a Southern California laboratory via the Internet.
The scientists used a new Internet-based laser scissor-and-tweezers technology called RoboLase, demonstrating the poten
Quantum dots programmed to glow in presence of enzyme activity
Researchers from Rice University’s Center for Biological and Environmental Nanotechnology (CBEN) have developed a “smart” beacon hundreds of times smaller than a human cell that is programmed to light up only when activated by specific proteases. Altered expression of particular proteases is a common hallmark of cancer, atherosclerosis, and many other diseases.
In the September issue of the journal B
A new sensor being patented by Ohio State University could be used to detect concealed weapons or help pilots see better through rain and fog.
Unlike X-ray machines or radar instruments, the sensor doesn’t have to generate a signal to detect objects – it spots them based on how brightly they reflect the natural radiation that is all around us every day.
There is always a certain amount of radiation – light, heat, and even microwaves – in the environment. Every objec
In a recent study published in the Journal of Biological Chemistry, scientists report on the discovery of a new molecule that is essential for degradation of the biopolymer chitin. This new molecule could eventually aid in the engineering of fungi-resistant plants and could also lead to the discovery of similar molecules that can be used in cellulose-based biofuel production.
The research appears as the “Paper of the Week” in the August 5 issue of the Journal of Biological Ch
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