Several pathological conditions as autoimmune and inflammatory diseases are due to an excessive T cell activity. Treatment modalities are based on the relief from symptoms, whereby immune suppressive biologicals are rapidly expanding, owing to the good efficacy and safety profiles. However, for the regulation of the starting point of the disease-causing processes no agents exist until now. For that we offer a new agent with an exceptional stringent and specific suppression of T cell activation, whereby the inactivation is reversible. With this invention it is not only possible to address T cells in their entirety, but also antigen-specific T cells. Membrane mobility characteristics have not to be considered, because the target is located on the outside of T cells.
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Some…
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