Basically, the idea is to control a variety of vehicle functions on a uniform, centralized computer platform instead of providing every system with its own…
Odile had weakened to a tropical storm with winds of about 55 knots (63.3 mph) when the TRMM satellite flew over on September 16, 2014 at 0917 UTC (2:19 a.m….
A Tropical Storm Warning is in force for the southwest coast of Mexico from Punta San Telmo to Playa Perula. A Tropical Storm Watch is in force from Punta San…
On Sept. 17, the National Hurricane Center noted “Swells from Edouard will affect portions of the east coast of the United States north of Florida beginning…
Glucose-rich diets have been implemented to contribute to the development of metabolic diseases such as diabetes, cardiovascular disease, obesity, and cancer.
The new vancomycin analog appears to have not one but two distinct mechanisms of anti-microbial action, against which bacteria probably cannot evolve…
In preclinical animal models of metastatic prostate cancer, scientists at Virginia Commonwealth University Massey Cancer Center, VCU Institute of Molecular…
The black hole is five times the mass of the one at the center of our Milky Way galaxy. It is inside one of the densest galaxies known to date — the M60-UCD1…
The aerospace medicine group at the University of Texas Medical Branch at Galveston recently studied how average people with common medical problems — high…
The movie shows IRIS imagery focused in on material at around 60,000 Kelvin (107,500 F), which highlights a low level of the sun's atmosphere, called the…
The experimental vaccine, developed by researchers at Washington University School of Medicine in St. Louis, prevented urinary tract infections associated with…
Why is it that when people are too stressed they are often grouchy, grumpy, nasty, distracted or forgetful? Researchers from the Brain Mind Institute (BMI) at…
Scientists at USC have developed a new microscopy technology that allows them to view single molecules in living animals at higher-than-ever resolution.
Research partners in this undertaking are the Graz University of Technology and industrial partners such as Audi, BMW, Daimler, Porsche and Volkswagen. This…
DNA-methylation (DNAm) of CpG dinucleotides is a key epigenetic process. Upon cell division, the DNAm pattern is maintained on the newly synthesized DNA strand by DNA methyltransferase 1 (DNMT1), whereas DNAm pattern changes are triggered by DNMT3A and DNMT3B that act as de novo methyltransferases.
DNMT3A and DNMT3B play a pivotal role in the epigenetic regulation and development of hematopoietic malignant myeloid disease, such as acute myeloid leukemia (AML) and myelodysplastic syndrome. About 22% of AML patients harbor mutations in DNMT3A, which likely cause the disease. However, little is known about how DNMT3s are epigenetically controlled.
The present invention provides a novel diagnostic and prognostic method for hematopoietic malignant myeloid disease. This method is based on the identification of aberrant hypermethylation at an internal promoter region of DNMT3A, which occurs in about 40% of AML patients.
Targeted therapy has become a promising therapeutic approach within the last decade due to its reduced toxicity. However, further development of targeted approaches for the specific delivery of therapeutically active substances is required. Especially the targeted delivery of macromolecular charged drug-like molecules, for example antagomirs and siRNA, is limited since these candidates do not cross cell membranes but rather have to be actively provided to the intracellular milieu.
The present invention provides novel aptamers capable of recognizing tumour cells and delivering macromolecular molecules into tumour cells. Aptamers are short single-stranded nucleic acids that recognize specific target structures with high affinity and specificity. Additionally, since aptamers have been shown to possess almost no toxicity and immunogenicity they are promising candidates for biomedical applications.
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