DGIST develops 20 times faster biosensor

This is a schematic of a biosensor platform resembling a spider web. Credit: DGSIT

The sensing capability of a biosensor is determined by the resolution of the sensor and the movement and reaction rate of molecules. Many research groups in Korea and other countries have been improving the resolution through the development of nanomaterials but there has been a limitation to improve the sensors' sensitivity due to the low diffusion transport of biomolcules toward the sensing region.

Professor Kim and his research team used a magnetic field in order to overcome the drawback that the movement of biomolecules such as proteins and DNA is slow when the transport only depends on diffusion.

The biomolecules labeled with superparamagnetic particles and the use of an external magnetic field enabled the movement of the biomolecules to be easily controlled and detected with an ultra-sensitive magnetic sensor.

The research team developed a new biosensor platform using a spider web-shaped micro-magnetic pattern. It improved the sensing ability of the biosensor as it increased the ability to collect low-density biomolecules by attracting biomolecules labeled with the superparamagnetic particles to the sensing area.

The first author Byeonghwa Lim at DGIST's Ph.D program of Emerging Materials Science elaborated on the biosensor platform, “We placed a spider web-shaped micro-magnetic pattern which was designed to move the superparamagnetic particles toward the center of the biosensor and a high sensitivity biosensor on the platform.

When a rotating magnetic field is applied to a spider web-shaped magnetic pattern, it can attract biomolecules labeled with superparamagnetic particles faster to the sensor. The speed of the movement is very fast and it can detect the subject 20 times faster than the diffusion method.”

The research team also succeeded in monitoring the biomolecules conjugated to the superparamagnetic particles at a distance from the sensing area by utilizing the biosensor platform. In addition, the team has identified that the superparamagnetic particles not only play the role of biomolecular cargo for transportation, but also act as labels for the sensor to indicate the location of biomolecules.

Professor Kim stated “The existing biosensors require long time to detect low density biomolecules and result in poor sensing efficiency as they only depend on diffusion. The magnetic field based biosensor platform improves the collection capability of biomolecules and increases the speed and sensitivity of the biomolecules movement. Therefore, we are planning to use this platform for early diagnosis as well as recurrence diagnosis of diseases such as cancer. “

Media Contact

Dahye Kim
pwrock@dgist.ac.kr
82-537-851-163

http://www.dgist.ac.kr 

Media Contact

Dahye Kim EurekAlert!

All latest news from the category: Physics and Astronomy

This area deals with the fundamental laws and building blocks of nature and how they interact, the properties and the behavior of matter, and research into space and time and their structures.

innovations-report provides in-depth reports and articles on subjects such as astrophysics, laser technologies, nuclear, quantum, particle and solid-state physics, nanotechnologies, planetary research and findings (Mars, Venus) and developments related to the Hubble Telescope.

Back to home

Comments (0)

Write a comment

Newest articles

New yttrium-hydrogen compounds discovered

Researchers at the University of Bayreuth have made a significant scientific breakthrough by discovering new yttrium-hydrogen compounds having serious implications for the research on high-pressure superconductivity. High-pressure superconductivity refers to…

New AI model detects ninety percent of lymphatic cancer cases

Medical image analysis using AI has developed rapidly in recent years. Now, one of the largest studies to date has been carried out using AI-assisted image analysis of lymphoma, cancer…

UTA preps giant particle detectors for neutrino project

Excavation of caverns part of Fermilab’s Deep Underground Neutrino Experiment. With excavation work complete at the site where four gigantic particle detectors for the international Deep Underground Neutrino Experiment (DUNE) will be…

Partners & Sponsors