Serum biomarkers for diagnosis of hepatocellular carcinoma (HCC)

Scientists from Goethe University of Frankfurt am Main have identified serum biomarkers that differentiate patients with hepatocellular carcinoma (HCC) from those with liver cirrhosis. The identified sphingolipid metabolites C16-ceramide and sphingosine-1-phosphate (S1P) provide an extraordinary high diagnostic accuracy (AUC value > 0.98). Current HCC tests measure levels of alpha-fetoprotein (AFP) which show a significantly lower diagnostic performance.

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