The hierarchical and precisely controlled process creating ribosomes in living cells is known as ribosome assembly and is relatively little researched. In the eyes of many experts the early processes in the creation of ribosomes offer attractive targets for antimicrobial agents. The systematic search for such substances is made more difficult by the fact, that currently no suitable screening processes exist.

The present invention consists of stable bacterial strains with ribosomal subunits incorporating fluorescent markers, which have growth characteristics similar to wild type, and which have an intact translation apparatus. The positioning of the fluorophores allows for disturbances in the ribosome assembly to be detected in vivo by a fluorescence-based readout process. The process has been optimized for use with multi-well plates and thus is suitable for use in high throughput screenings (HTS).

Male moths locate females by navigating along the latter’s pheromone (odor) plume, often flying hundreds of meters to do so. Two strategies are involved to…

Limitation of natural sources, especially of fossil resources, for base material that is currently used to produce polyamides and related composites together with the increasing demand of these products, promotes the search for renewable sources of the base material. Fermentation by genetically engineered bacteria gains increasing interest as one of these possible sources.
Cadaverine is a biogenic amine that can be produced by Corynebacterium glutamicum from the amino acid lysine by heterologous expression of a lysine decarboxylase from Escherichia coli.
Overexpression of the patA and patD genes from Escherichia coli in Corynebacterium glutamicum enables the latter to further metabolize cadaverine to 5 aminovalerate (5AVA), which is a potential base material for the production of nylon 5 and a C5 platform for the synthesis of base materials for other polyamides.
Chemical industry is facing an increasing demand on polyamides and related composites, whereas in contrast the accessibility of base material from fossil sources for their production alleviates. Therefore, in seek for alternative and renewable sources, bacterial fermentation has become into focus in several chemical production areas. The offered invention provides such a source for nylon production and related composites.

A team of scientists from the U.S. Department of Energy’s Brookhaven National Laboratory and Lawrence Berkeley National Laboratory designed, created, and…

The hormone acts as a barrier against SARS-CoV-2, blocking the expression of genes that encode proteins in cells serving as viral entry points, according to a study by researchers at the University of São Paulo. By Elton Alisson  |  Agência FAPESP – Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2, preventing expression of genes that encode proteins in cells such as resident macrophages in the nose and pulmonary alveoli, and epithelial cells lining the alveoli, all of which…

Melting causes accelerated ice loss at tidewater glaciers, releasing pressurized bubbles. As the world’s temperatures rise, tidewater glaciers are receding and melting, releasing air trapped in the ice. Scientists can listen to the release of the air and potentially use the sounds to help them gauge the impact of climate change on the ice floes. During the 181st Meeting of the Acoustical Society of America, which will be held Nov. 29-Dec. 3, Hayden Johnson, from the University of California, San…

Project 8 marks a major milestone in its quest to measure neutrino mass. The humble neutrino, an elusive subatomic particle that passes effortlessly through normal matter, plays an outsized role among the particles that comprise our universe. To fully explain how our universe came to be, we need to know its mass. But, like so many of us, it avoids being weighed. Now, an international team of researchers from the United States and Germany leading an ambitious quest called Project…

Mission to find gamma ray bursts is latest to use technology from University of Leicester in X-ray optics. A satellite telescope designed to rapidly hunt down the universe’s biggest explosions will launch later this week, carrying technology developed at the University of Leicester. The Space Variable Objects Monitor (SVOM) is the second mission this year to benefit from expertise in X-ray optics at Leicester, following the launch of Einstein Probe in January. The SVOM mission (Space-based multi-band astronomical Variable Objects…

University of Utah researchers develop potential alpha-particle treatments that target the plaques on the brain that lead to dementia. Alzheimer’s disease, a debilitating brain disorder with limited treatment options, has long challenged researchers. Specifically, researchers have struggled with slowing the buildup of amyloid beta plaques, harmful clumps of proteins that exacerbate the disease by damaging brain cells and causing memory loss. Led by the John and Marcia Price College of Engineering, University of Utah researchers have developed a groundbreaking approach…

Study of malaria parasite genomes paves the way for new, more effective treatments. Researchers at University of California San Diego analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance. The findings, published in Science, could help scientists use machine learning to predict antimalarial drug resistance and more effectively prioritize the most promising experimental treatments for further development. The approach could also help predict treatment resistance in other infectious diseases,…

Disinfecting male birds might not help curb Lyme disease.

Treating male pheasants against the ticks that carry Lyme disease might do more harm than good. Tick-free males are more sexually attractive, so untreated males are forced to roam farther in search of mates, possibly spreading ticks as they go.

A blood-dwelling bacterium called Borrelia causes Lyme disease, famed for its arthritic symptoms. Ticks spread the bug when they bite rodents, birds, deer and humans.

Research aimed at finding new diagnostic tests for BSE is gathering momentum at the Institute of Grassland and Environmental Research (IGER), where scientists have won a major research contract worth over £500,000 from the Department for Environment, Food and Rural Affairs (DEFRA).

`The new contract will help us expand our search for biochemical markers associated with BSE and scrapie,` said Professor Mike Theodorou, one of the leaders of the four-year programme. His colleague, Dr Gordon All

New VLT Discovery Pushes Back the Beginnings

Using the ESO Very Large Telescope (VLT), a team of astronomers from The Netherlands, Germany and the USA [1] have discovered the most distant group of galaxies ever seen, about 13.5 billion light-years away. The Photo shows the sky region near the power

A University of Ulster researcher has discovered a new population of cave dwelling crocodiles, never before seen outside their Saharan habitat.

PhD student Tara Shine discovered the cave dwelling crocodiles while living in the remote African country of Mauritania as part of a two and a half year volunteer project.

Previously unknown, except by local tribespeople, the crocodiles live in burrows and caves throughout the dry season and periods of drought – a phenomenon never

About 30 years ago, astronomers realised that the Sun resonates like a giant musical instrument with well-defined periods (frequencies). It forms a sort of large, spherical organ pipe. The energy that excites these sound waves comes from the turbulent region just below the Sun`s visible surface.

Observations of the solar sound waves (known as “helioseismology”) have resulted in enormous progress in the exploration of the interior of the Sun, otherwise hidden from view. As is the case on Eart

Gold prospectors may one day rely on lowly bacteria to point them to deposits of the precious metal. Researchers have discovered that gold-laden soil often contains an abundance of spores belonging to a certain bacterium. The affinity humans have for gold aside, the ore in its soluble form is actually highly toxic to most living things. The common bacterium Bacillus cereus , however, possesses a unique resistance to the metal, allowing it to survive in a relatively vacant environmental niche:

Rich and Inspiring Experience with NGC 300 Images from the ESO Science Data Archive
A series of wide-field images centred on the nearby spiral galaxy NGC 300, obtained with the Wide-Field Imager (WFI) on the MPG/ESO 2.2-m telescope at the La Silla Observatory, have been combined into a magnificent colour photo.

These images have been used by different groups of astronomers for various kinds of scientific investigations, ranging from individual stars and nebulae in NGC 300, to distant gal

Advance Should Speed Semiconductor Industry Search

Researchers from the Commerce Department’s National Institute of Standards and Technology (NIST) reported today they have developed methods for characterizing key structural features of porous films being eyed as insulators for the ultrathin metal wires that will connect millions of devices on future microprocessors and increase processor speed. The advance, reported today at the American Chemical Society’s national meeting

British astronomers, together with Australian and American colleagues, have used the 3.9m Anglo-Australian Telescope [AAT] in New South Wales, Australia to discover a new planet outside our Solar System – the 100th to be detected. The discovery, which is part of a search for solar systems that resemble our own, will be announced today (Tuesday) at a conference on “The origin of life” in Graz, Austria. This takes the total number of planets found outside our solar system to 100, and scientists are now

New research enables computers to name that tune

A team of British and American scientists claim a world’s first in online music recognition, paving the way for the musical equivalent of web search-engine Google; and the potential to resolve musical copyright disputes. Researchers at Queen Mary, University of London; King`s College London; Oxford University and the Universities of Indiana and Massachusetts have developed a new system which enables computers to recognise complex pieces