A new generation of biocompatible and biodegradab le polymers for tissue engineering has been developed. The liquid precursors can be either cured in vivo or printed by additive manufacturing technology.

NeuNAc is used as a precursor for the production of neuraminidase inhibitors, which are used for the treatment of viral diseases. {e.g. drug Relenza). A new process was developed at the TU Vienna combining the advantage of a single-step process and using the cheap and renewable substrate chitin.

The core of this invention is a combination of analytical and experimental methods, which allow a fast, cheap and easy way to identify different observable physiologic states in a BMP process.

The purely optical compensation of errors in encoder readings allows for robust sensor design with alignment-free assembly of the encoder disc. Due to a diffractive compensation track the beam spot on the measuring track can be compensated prior to sensor signal generation.

The present invention relates to new water soluble single source intumescent flame retardants. The commonly used retardants are often seen as a health concern and tend to falsify the natural look of wood.

The Invention describes a novel class of kappa Opioid receptor (KOR) ligands which can be used for the therapy of a variety of human disorders.

The Invention describes novel analogues of 14-methoxymetopon(14-MM) a µpioid receptor (MOR) Ligand with a unique pharmacological Profile, for the Treatment of moderate-to-severe acute and chronoc pain.

The Marine Environmental Research Center established jointly by KAUST and Saudi Aramco is the first oceanic observatory capable of monitoring the Red Sea.

The present invention relates to a plant and a procedure for separating gold or other metal particles from a mixture of particles by applying dielectrophoresis. The physical separation method specifically separates metals, e.g. gold, from a suspension. This is accomplished by a special configuration of electrodes allowing for the creation of an electric field which is selective to metallic particles. The new method replaces environmentally hazardous cyanide leaching almost completely and thus considerably reduces the amounts of the chemicals that need to be applied.

At University of Bremen a new wound healing strategy has been presented: The team of the Wound Repair Unit at the Centre for Biomolecular Interactions Bremen (CBIB) has shown the influence of lung surfactant on keratinocytes and the benefit of these interactions for cell migration and wound resurfacing. Lung surfactants contain phospholipids and surfactant proteins and are used as standard therapy for respiratory distress syndrome in preterm infants.

There is currently a strongly growing need for methods and chemicals for the preparation of large biological samples for three-dimensional imaging. The invented substance and protocol are of high interest for any supplier or company in the field of microscopy and imaging techniques. The unique selling proposition is that the herewith offered invention constitutes the sole methodology optical clearing of biological samples without use of harmful chemicals combined with high quality fluorescence preservation. The invented substance and protocol is routinely used by the inventors and has thus been shown to be robust for general laboratory usage.
On behalf of the University of Duisburg and Essen, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development, e.g. of a kit. In case of interest we will be pleased to inform you about the patent status.

We have developed a new method for improvement of cellulase and hemicellulase production in Trichoderma reesei by overexpression of a developmental regulator.

The present invention specifically provides a novel vaccine formulation
suitable for ocular immunization and provides a method for inducing a local and systemic immune response. The combination of the three components antigen & corpusculate bodies (eg.Bortedella pertussis (wBP)) & adjuvans showed the highest rise in IgA antibody titers in tears and sera when compared to other immunization groups. Immunization via the conjunctiva with TTd plus wBP and adjuvant resulted in a 33% survival rate of challenged mice compared to a 0% survival rate in non-immunized animals.

USE OF ERYTHROPOIETIN FOR THE TREATMENT OF
FRIEDREICH´S ATAXIA:
In addition to its neuro- and cardioprotective properties recombinant human erythropoietin (rhuEPO) significantly increases frataxin expression in primary lymphocytes from FApatients, and other cell types like neurons and primary human cardiac cells in vitro. (Sturm et.al 2005, Eur. J.Clin. Invest. 35(11):711-7) rhuEPO was successfully tested as a treatment for Friedreich`s ataxia in Phase IIa/IIb and dosefinding studies.

Pathological calcification processes in the human body are often the
beginning of a series of diseases which relate to organ systems such as the vascular system of the heart, and kidney. As a consequence of metabolic diseases such as diabetes, calcification processes can lead to severe impairments of health or to death. Therefore, it is of scientific and economical interest, to develop new approaches for quick and inexpensive treatments of these diseases. Already known calcification biomarkers provide an indication of occurring calcification processes but still can’t make a statement about triggering factors, which will be possible with our in vitro calcification model, CALCI-QUICK.

Researchers of the Medical University of Vienna have identified highly
active synthetic chalcones derived from the chalcone scaffold. These
cytotoxic compounds were found and developed by modifying the
chalcone lead structure concurrent with in vitro tests to evaluate their
cytotoxic potential in different cancer cell lines. Compounds were
thoroughly tested regarding their efficacy in inhibiting proliferation and
viability in cancer cell lines of the hematopoietic system. The combination of the new chalcone compound with the targeting agents, Idelalisib and Ibrutinib, which are novel compounds in the treatment of hematological malignancies, displayed higher cytotoxicity on CLL cells than Idelalisib and Ibrutinib alone.

The proposed methodology is an important step towards image-analysis
based individualization of patient management and treatment in one of the most cost-intensive fields of modern medicine. We propose to
identify and quantify retinal morphology using deep learning algorithms
such as convolutional neural networks (CNN) and to predict future
disease progression patterns and treatment response in patients based on spatio-temporal signatures.

The invention describes a system, which is used to monitor the ingrown and loosening status of an implant.
To achieve this, body sound and ultrasound sensors are placed on the surface of the prosthetic. These sensors are able to detect micro friction processes, caused by a relative movement between the artificial hip and the surrounding soft and hard tissue. In addition, the system is capable of using ultrasound to monitor the ingrown and loosening status.
By doing so, the invention delivers a measurement system for a non invasive and radiation free examination of the loosening and the ingrown status of hip replacement implants. This system would be able to reduce the number of unnecessary revision surgeries and thus could be able to reduce the costs caused by such opera-tions.

The invention delivers a new constructive design of the ultrasonic transducers to enhance the usability of ultrasonic material testing. The device described in the invention is constructed with a great number of piezo electric transducers on the surface of the probe. Those piezo electric elements are placed like mosaics on a flexible surface, which is placed on a rodshaped carrier. This surface is now able to adapt to the surface of the testing body, which means that a great number of complex surfaces can be tested with this system.
The carrier includes several channels, which are able to constantly supply the ultrasonic transducers with a gel. This gel is used as the coupling agent for an opti-mized sound transfer.

A solution for the known difficulties is given with this invention. Therefore a rotating valve is described. This valve controls the fluid flow in the system without getting in touch with the fluid itself. To do so, the valve heads are pressed on the flexible fluid pipes, which causes the flow through this point to stop. The valve heads are moved by electrically con-trolled actuators which perform a rotation movement. Unlike with membrane valves, additional energy to keep the valve open or closed is not required. Furthermore it is possible to use miniature servo actuators for the movement of the valve heads.