Crash Alerter is a newly developed mobile technology for automatic and secure accident alert and emergency messages.
Current accident alert technologies are built-in systems in up-segment trucks and cars. The Crash Alerter technology, however, is suitable for use in all types of vehicles, including motorbikes and bicycles. Previous mobile emergency message technologies were unable to provide false-safe alerts. The Crash Alerter is a novel solution that uses motion and speed data to reliably avoid false alarms. The monitoring system is activated automatically by defined movement and in that state interprets “irregular” accelerator data readings as an accident.
If the user does not cancel the alarm, Crash Alerter sends an emergency message to a pre-set address (e.g. emergency services), giving the vehicle’s current position (e. g. GPS coordinates) as well as other user-defined data.

This novel driver assistance system allows for a situation- adjusted visualisation in the correct direction as well as a selection of possible manoeuvres in a semi-automated vehicle guidance concept. With this concept, the distance travelled by the vehicle in the future is graphically displayed to the driver during the selection. Driving a vehicle can therefore be greatly simplified and reduce the burden on the driver, thereby resulting in a comfortable driving experience.

Paratuberculosis or Johne’s disease is a contagious, chronic and also fatal bacterial infection, which generally occurs early in life. The disease can exist undetected in a herd for many years. Scientists at the University of Göttingen developed an improved PCR diagnostic test for fast and early detection of Paratuberculosis.

The invention is a lightweight element / semi-finished part with an extensive surface consisting of at least two layers of sheet metal and one structured sheet metal. The structured blank is typified by macro-stiffening elements without any markedly flat even sections and has a honeycomb form. The single blanks are laid on top of each other and held together by joints. Components may be straight or bent, according to need. The invention not only markedly increases the stiffness characteristics of the light-weight elements but also minimizes the weight.

The wide use of recombinant polypeptides is limited by still insufficient means of production, namely, their expression in host cells. The most often used bacterial host cells generally have the considerable drawback that polypeptides of eukaryotic origin are not folded correctly and that undesirable posttranslational modifications may occur. One of the most severe drawbacks is that the target polypeptide is typically located in the cytoplasm of the host cells and must be isolated from said cytoplasm in a laborious, time-consuming and expensive downstream-processing.
In view of the above, an expression system is needed that is usable in an eukaryotic cell extensively autologous with respect to sugars, amino acids and that is extensively independent of growth factors. It has been shown that plant cells, in particular microalgae cells, can be used for the production of recombinant proteins and overcome most of the above problems.
Microalga cultures are comparably easy to handle and, in principle, scalable to large production scales. Furthermore, microalgae merely require a slightly salty aqueous environment, CO2 and light, can be supplemented by simple carbon sources, or a combination of these strategies to grow rapidly and produce the recombinant protein of interest. Therefore, the cultivation of microalgae is relatively inexpensive. These cultures can be extensively free of sugars and amino acids. The use of solar energy to produce biomass and recombinant protein production is an attractive aspect of these cells in light of the goal of sustainability.
Unfortunately, the efficient production of recombinant proteins in microalgae is hampered because of the tightly regulated gene expression, preference for certain nucleic acid codon usage, and bias to its own promoters.
The present invention allows to overcome these problems with highly efficient production and direct secretion of target polypeptides into the medium and in addition enables simultaneous monitoring of the polypeptide production without disturbing the expression system.
This system has in principle a large range of applications and may be used due to the safe organism for researchers, pharmaceutical targets and food and feed producers.

A novel B1-mapping technique (B1-TRAP) is presented, which offers a good compromise with respect to speed, robustness and accuracy.

The present invention relates to the preparation of in situ-forming hydrogels by cross-linking macromonomers using the Diels-Alder reaction. Hydrophilic macromolecules are functionalized with dienes and dienophiles; the number of functionalities is at least two per macromonomer. The macromonomers are cross-linked in aqueous solutions outside or inside the human body by a [4+2] cycloaddition reaction to form highly elastic hydrogels. The hydrogels can be used as biomaterials for biomedical applications, as scaffolds for living cells, or as delivery system for the controlled release of proteins.

Wireless sensor system for the assembly process creation

The present invention relates to antibodies that exhibit a high affinity and specificity for the A1/B-domains of CEACAM1.

Commercial Opportunities
CEACAM1 is an adhesion receptor molecule implicated in growth regulation and the development of cancer. It belongs to the family of carcinoembryonic antigens which forms a part of the immunoglobulin superfamily (IgSF). CEACAMs play a central role with respect to cell adhesion, differentiation, activation, proliferation, morphogenesis and apoptosis as well as receptors for various pathogens (e. g. bacteria). CEACAMs are structurally closely related: they feature the function triggering N-domain and a C-domain consisting of A- and B-domains. Due to the structural similarity it is very challenging to obtain antibodies against specific CEACAM1-domains. CEACAM1 has been detected at elevated levels in the surrounding tissue of tumors and the tumors themselves. It appears that CEACAM1 is a suitable biomarker for the diagnosis and staging of tumors.

The present invention relates to antibodies that exhibit a high affinity and mono-specificity for the A1/B-domains of human CEACAM1. Thus, they are suitable to detect the membrane anchored, the cleaved soluble CEACAM1 and most of its derivatives and may be used in various in-vitro techniques in cancer research, e.g. ELISA, WB, IHC, fluorescence microscopy and flow cytometry.

Hydrogen sulphide is a highly toxic and corrosive environmental pollutant with an obnoxious smell, the removal of which is necessary for pollution control and processing requirements within industry.

The invention demonstrates that specially modified iron, manganese, cobalt and nickel porphyrins can be used for the efficient catalytic removal of hydrogen sulphide species (H2S, HS-, S2-), here labelled “H2S”.

The invention describes a method to produce connections with friction welding. It has a significantly lower thermal stress than existing methods.

This metering device is highly flexible because of its ability to process fine powders. It expands the possbilies in rapid prototyping or avoids high precision scaling in food or pharma precesses.

A self-piercing blind rivet is provided for apposing biological tissue together with a device for setting the same, especially through the instrumental channel of a flexible endoscope.

The invention shows the use of miR-24 modulation to interfere with angiogenic signalling in vitro and in vivo. MiR-24 is triggering endothelial cell (EC) apoptosis via a signal cascade involving the mediators GATA2, PAK4 and others. This is also accompanied by a deficient angiogenic response. MiR-24 antagonism can block these detrimental effects. In a murine model of myocardial infarction (MI) reflecting ischemic disease, miR-24 expression is enhanced specially in cardiac ECs. Following MI, therapeutic intervention with a miR-24 specific antagonist lowered endogenous miR-24, preserved cardiac function and improved capillary density. The same pro-angiogenic effects were seen when implanting matrigel plugs to mice after treatment with miR-24 inhibitors. Thus, therapeutic knockdown of miR-24 is beneficial for cardiac performance upon MI and likely many other ischemic diseases. Collectively, miR-24 modulation can be useful in different settings of ischemic disease to sustain vasculature. As we have investigated therapeutic miR-24 intervention upon MI and in implanted matrigel plugs, we conclude that our results can be transferred to other ischemic stress models like hindlimb ischemia (peripheral occlusive disease), ischemic gut diseases, ischemia of virtually all organs such as kidney, liver, brain, spleen, dermal tissue, lung and others. In addition surgical operations and organ transplantation often result in ischemia-triggered organ function, which could be a target of miR-24 inhibitory therapies.

This invention describes a medium for identification and authentification goods, based on periodic, three-dimensional surface structures.

The invention describes a highly sensitive semiconductor heterostructure for the detection of electromagnetic waves. The prototype works at room temperature in the range of 400nm – 4 µm. Expanding the detection range to lower wavelengths, e.g. in the soft x-ray range, should also be possible. The sensor is sensitive enough to detect single photons with a count rate of a few hundred MHz. The active area has a diameter of only 100 nm to a few µm.

Vascular disrupting agents (VDA) can overcome the multidrug resistance of tumors by targeting specifically tumor vasculature. The present invention relates to specific analogs of combretastatin in the treatment or prevention of cancer, including multidrug-resistant and combretastatin-refractory cancers.

Developmental Status: Pharmacodynamical and toxicological studies currently in the works , Animal data available, Further mouse studies on tumor xenografts from other entities planned, Compound samples available for testing

Sleep disordered breathing is a common condition in western countires and
moreover in asia. Patients affected suffer from daytime sleepiness and a variety
of disorders associated with sleep apnea. In Bavaria, 24% of traffic accidents
are caused by sleepiness. The gold standard therapy for sleep apnea is
nasal continous positive air pressure (nCPAP). This treatment shows excellent
results in the sleep lab but low acceptance on the long run.

A novel silicone implant prevents the relaxed tongue from protruding backwards
to the posterior pharyngeal wall. Functionality of the tongue is not impaired.
Patients don´t realise the implant during daytime.

The two areas of online transaction processing (OLTP) and online analytical processing (OLAP) present different challenges for database architectures. We present an efficient hybrid system, called HyPer, that can handle both OLTP
and OLAP simultaneously with unprecedented high transaction rates as high as several 100000 per second and ultra-low OLAP query response times of as low as 10 ms. Moreover one can creates transaction consistent backup archives of the entire database.

Seit einigen Jahren unternehmen Forscher Anstrengungen, um Lösungen zu finden, wie supraleitende, ferroelektrische und ferromagnetische Oxide strukturiert werden können, ohne dabei die intrinsischen Eigenschaften der Materialen zu verändern.
Sächsischen Wissenschaftlern ist es nun gelungen, ein einfaches nasschemisches Verfahren zu entwickeln, mit dem genau dieses Ziel erreicht wird. Neben der einfachen Ätzung, steilen Ätzkanten für nm-Strukturen ist es auch möglich, multi-layer zu strukturieren.
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