The Institute of Aircraft Design (IFB) at the University of Stuttgart developed a flexible pressure roll mechanism for braiding machines, which significantly improves the automated braiding of components with sharp curvatures and widely varying cross-sections without the need for manual intervention. While overbraiding a mandrel the flexible mounting of the pressure rolls allows for adaptation to the mandrel's positioning (e.g. inclined position) and to changes in the cross section. They exert a constant and precisely defined force on the braid and thereby press it against the mandrel.
As part of the automated process, the robot control of the braiding machine coordinates the movement of the pressure rolls. This significantly improves the braiding of components with a variable cross-section and curvatures so that manual intervention is no longer required.
Based on a very thin, high-strength design of the invention the ultrasonic sensor is placed between the teeth of the approximal region, thus reducing the distance significantly. As a result the images posses a very high spatial resolution.
The ultrasonic sensor consists of a metallic base plate with a reinforced frame, made of high-strength pure titanium or a TiAl6V4 alloy. The edges of the frame are rounded to make the insertion in the approximal region more comfortable. The total thickness of the design is limited to a maximum of 0.8 mm. The piezoelectric part is made on a PVDF-film equipped with spacers and shielded by an adjustable cover. The cover allows for a special contact by respecting the safety clearance to the teeth. By removing the cover hydrogel is pumped into the gap to provide acoustic coupling. In addition, it is used for lubrication of the cover movement.
The present invention comprises a buffer memory for combined cycle (CC) power plants, which mitigates the effect of accelerated startup and shutdown of the gas turbine on the heat recovery steam generator. Hence, CC Power Plants are enabled to exploit the full potential of their gas turbines in the growing balancing power market without having to accept increased degradation of the waste heat boiler
Scientist at the Westfälische Wilhelms University of Münster developed the efficient Cu-catalyzed PEN method for the formation of tetra-substituted pyrazoles. In this atomeconomic process, readily available enamines and nitriles are reacted by C-C and N-N bond formation. A broad scope of enamines and nitriles can be utilized in this process.
The invention relates to a sample holder to be used in cryo fluorescence microscopes or to simply and cost effectively upgrade a room temperature fluorescence microscope. The holder solves existing problems regarding thermal and mechanical stability of the sample and allows for a localization accuracy of a few hundred Angstroms.
A new embodiment of a braiding machine was developed at the Institute of Aircraft Design (IFB) of Stuttgart University. It features a thread positioning unit which forms a secondary ring of horn-gears close to the braiding point. This secondary ring moves synchronously with the primary horn-gears of the braiding machine. Therefore, the position of each thread, that is close to the mandrel, is clearly defined. This is a basic requirement for manipulation of specific threads during the braiding process, which in turn permits the automated production of components with highly varying diameters at a constant braid angle.
The agonistic prodrug Fingolimod (FTY720) en-abled the first oral treatment of relapsing-remitting multiple sclerosis by modulating sphin-golipid signaling. Scientists developed novel Fingolimod non-prodrug derivatives, which re-duce the blood-brain-barrier leakage and blood T lymphocytes. Advantageously one derivative is fully active in the absence of sphingosine ki-nase 2 while exhibiting comparable activity to Fingolimod.
Scientists from Goethe University Frankfurt developed a new mobile device to determine ad-hoc coagulation times from full-blood samples utilizing “surface acoustic waves”. This coagulation time is of high importance e.g. during emergency situations when the coagulation status of a patient under anticoagulant therapy needs rapid evaluation.
Moguntinones, a class of small molecule compounds comprise 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives with tumor and vascular targeting properties. The present invention relates to the use of Moguntinones for treatment of colorectal or gastric adenocarcinoma.
Tumor growth and metastasis are highly associated with the overexpression of protein kinases. Therefore protein kinases are an interesting class of target molecules for improved therapeutic attempts. These proteins are known to regulate the majority of cellular pathways including such relevant for control cell growth, movement and death – all processes relevant for cancer growth and progression.
A physiological process focused on in development of anti-cancer agents is apoptosis, a controlled form of cell death eliminating damaged, aberrant, infected, old or superfluous cells. In particular often mucosa tissue such as gastrointestinal mucosa is characterized by a rapid epithelial cell turnover in which homeostasis is maintained predominantly by apoptosis.
One essential prerequisite for growth and metastasis of cancers which form tumors is angiogenesis, a process involving the formation of new blood vessels from pre-existing capillary endothelial cells. Tumor cells may enhance angiogenesis by overexpression of proangiogenic factors, e.g. VEGF or interleukins. In general, this is especially pronounced with tumors having a high microvessel density as well as a particular aggressive behavior and high tendency to metastasize. Therefore, inhibitors of angiogenesis are researched as antitumor agents.
[Ref. UMZ252]
The inventive method allows the context-sensitive indexing of hemodynamic parameters. For the indexation of hemodynamic and biochemical parameters a more specific adjustment based also on non-biometric data can be used to more accurately assess and easily access the parameters and thus simplify and improve the care of critically ill patients.
The present invention addresses the AD-converter in the receiver which is in respect to power consumption a highly crucial component. By reducing the resolution down to 1 bit and simultaneously improving the signal-to-noise ratio by a new demodulator concept the invention offers a cost and power efficient design for the RF front-end.
Eye drops of blood serum are an established and very effective therapeutic agent in many ophthalmological diseases such as keratitis and dry eye syndrome.The production of serum eye drops and the partition in one-day-doses must be operated under clean room conditions in order to prevent any contamination of the eye drops.
This product allows a fast and easy production of eye drops from blood serum without the need of a clean room laboratory. The single use product utilizes a closed system, which guaran-tees the sterility of the serum eye drops.
Electrical sensing array for the detection of multiple biological or chemical species in complex samples with applications e.g. in chemical analysis and medical diagnostics.
Such a device allows for simultaneous and spatiotemporal detection of concentration gradients in test samples. A direct integration of the proposed sensor array into many kinds of sensing platforms like microfluidics or lab-on-a-chip systems is possible and a combination with conventional optical read-out techniques can be realized.
Itaconic acid (ITA) – also known as methylenesuccinic acid or butanedioic acid – is one of the top 12 bio-based chemical building blocks and thus a promising platform compound for production of biofuels, chemical compounds, including e.g. detergents, and polymers, including plastics and artificial glass.
Itaconic acid (C5H6O4) is an organic dicarbonic acid which is soluble in water, ethanol, and acetone.
The new method for production of itaconic acid uses genes encoding for the itaconic acid biosynthesis pathway of the genus Ustilago maydis.
Invention of a stretcher on wheels for rescuing persons on big events with increased ease of operation for the rescue staff. The retractable cover protects the patient from rain and looks of bystanders.
Temperaturstabilisierung ist bei hochauflösenden Mikroskopen sehr wichtig. Die von DKFZ entwickelte Technologie ermöglicht mit Durchstrom von exakt temperierter Flüssigkeit durch die Temperiereinheiten die genaue Regulation der Temperatur und somit eine Wärmeaufnahme und -abgabe am Mikroskopaufbau.
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