Scientists at the Georg-August-University Göttingen produced different monoclonal antibodies directed against phosphorylation sites of CCR5. These antibodies…
Scientists at the Georg-August-University produced a monoclonal antibody which recognises murine CD197, a 43kD member of the G coupled receptor family, which…
Scientists at the Georg-August-University Göttingen produced different monoclonal antibodies directed against phosphorylation sites of CCR5. These antibodies have been demonstrated to exclusively recognise CD195 phosphorylated at Ser 337 or Ser 349. Human CD195 is a member of the G protein coupled superfamily of receptors, which acts as a receptor for a member of chemokines including RANTES and also serves as a co-receptor for the entry of HIV into cells. It plays a key role in regulating the activation and migration of leukocytes. CD195 is expressed by a subset of T-lymphocytes and by monocytes. Using these antibodies e.g. in combination with our indicator cell line ligand induced phosphorylation or dephosphorylation of CCR5 can be directly measured without using more indirect indicators like Ca++ concentrations.
This principle can be extended to measure activation states of G protein coupled receptors or activity of GPCR kinases generally, e.g. when screening for new agonists, antagonists or GRK inhibitors.
Scientists of the University of Göttingen developed new highly potent drugs (with an IC50 in the pico-Molar range) as well as a selective tumor therapy through…
The invention relates to functionalised diols of diamondoids in which one of the two hydroxy groups is masked by a protective group, and to methods for…
At a German University a manufacturing technique suitably for membrane electrodes was developed. The main advantage is the usage of less platinum (up to 30%),…
The invention at hand provides, for the first time, thermally stable trisaryl compounds of the rare earth metals which are storable for a long time. These…
With our invention, physically handicapped people are able to control different equipment without using extremities, voice or eye-moving. Just by using…
With the signal of ear muscles its possible to control a game console. All our test persons were able to learn to use this kind of controller in short time.
Further Information: …
With the signal of ear muscles its possible to control a game console. All our test persons were able to learn to use this kind of controller in short time.
The present invention is a novel principle for the use of electroactive polymers (EAPs). It is realised by a tubular device that contains the polymer. An…
The invention relates to the field of mobile data connections, in which a mobile node, e.g. a notebook is connected to a fixed node like a wireless router.Further Information: …
The invention at hand provides cyclopentadienylphosphazene complexes (CpPN complexes) of the metals of the third and the fourth group and of the lanthanoids…
A molecular rectifier comprised of a diamondoid molecule and an electron acceptor attached to the diamondoid molecule is now available. The electron acceptor…
This invention exploits the remarkable differences in the antimicrobial properties shown by human beta-defensins 2 and 3 (HBD2 and HBD3) against Gram-positive…
A molecular rectifier comprised of a diamondoid molecule and an electron acceptor attached to the diamondoid molecule is now available. The electron acceptor is generally an electron accepting aromatic species covalently attached to the diamondoid. Hereby, the diamondoid molecule fulfills the role of an electron donor.<p>
It has been discovered that rectification at the molecular level can be achieved by combining a diamondoid molecule with an electron acceptor ? most notably an aromatic one. Depending upon the particular combination of diamondoid molecule with electron acceptor, these molecules may act as rectifiers, resistors, p-n junctions, or a combination thereof.
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