The PlasmaCone® is a new inventive atmospheric pressure plasma source for applications as local or sequential plasma cleaning and plasma treatment by a plasma…
The invention shows the use of miR-24 modulation to interfere with angiogenic signalling in vitro and in vivo. MiR-24 is triggering endothelial cell (EC) apoptosis via a signal cascade involving the mediators GATA2, PAK4 and others. This is also accompanied by a deficient angiogenic response. MiR-24 antagonism can block these detrimental effects. In a murine model of myocardial infarction (MI) reflecting ischemic disease, miR-24 expression is enhanced specially in cardiac ECs. Following MI, therapeutic intervention with a miR-24 specific antagonist lowered endogenous miR-24, preserved cardiac function and improved capillary density. The same pro-angiogenic effects were seen when implanting matrigel plugs to mice after treatment with miR-24 inhibitors. Thus, therapeutic knockdown of miR-24 is beneficial for cardiac performance upon MI and likely many other ischemic diseases. Collectively, miR-24 modulation can be useful in different settings of ischemic disease to sustain vasculature. As we have investigated therapeutic miR-24 intervention upon MI and in implanted matrigel plugs, we conclude that our results can be transferred to other ischemic stress models like hindlimb ischemia (peripheral occlusive disease), ischemic gut diseases, ischemia of virtually all organs such as kidney, liver, brain, spleen, dermal tissue, lung and others. In addition surgical operations and organ transplantation often result in ischemia-triggered organ function, which could be a target of miR-24 inhibitory therapies.
Cyclohexane compounds and their use as antibiotics.
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Related Art – Basically a Class D power amplifier compares an input voltage with a saw tooth reference. The comparison yields a pulse series with a duty cycle…
Bone cements based on polymethylmethacrylate (PMMA) are mostly used for the anchorage of artificial joints, as bone substitutes at backbone diseases or after…
The invention offers two new packaging methods for pills and ointments. Advantage of the packagings is the one-hand operation and the sterile application of…
Peptide fragments of the C3 exoenzyme of Clostridium botulinum have been found to have neuritogenic effects on neurons as well as regenerative properties in an…
Alzheimer's Disease (AD) is the main neurodegenerative disease worldwide affecting more than 29 Mill. people. By 2050 the prevalence will quadruple, by thich…
Alzheimer's Disease (AD) is the main neurodegenerative disease worldwide. It places a large social and financial burden on society due to the need of life-long…
Steroid-related cancers have the highest incidence among tumors and its market potential for Europe and U.S.A. is estimated to be at least US$ 2.4 bn p.a. …
The new sensor serves for a three dimensional detection of an object by using electromagnetic high-frequency radiation in the THz frequency range.
The sensors…
This sensor is based on an antenna structure which is arranged together with at least one field effect transistor on a single substrate.
The sensor serves in…
The novel method and device uses an optic parametric source and enables the generation and phase-sensitive detection of coherent terahertz radiation.Further…
The new electro-optical camera provides a 2-dimensional detection of high-frequency radiation with a plurality of pixels.
The cameras basis is build by an…
The new resistive mixer is suitable for mixing or detecting an electrical or electromagnetic signal, even high gigahertz and terahertz frequencies.
Basis of…
Vapour deposition processes permitting the deposition of layers or structures of a defined material onto substrates are frequently used for the editing of…
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