Young stars ejecting plasma could give us clues into the Sun’s past Kyoto, Japan — Down here on Earth we don’t usually notice, but the Sun is frequently ejecting huge masses of plasma into space. These are called coronal mass ejections (CMEs). They often occur together with sudden brightenings called flares, and sometimes extend far enough to disturb Earth’s magnetosphere, generating space weather phenomena including auroras or geomagnetic storms, and even damaging power grids on occasion. Scientists believe that when…
The briefing will cover select topics being presented at the 162nd meeting of the Acoustical Society of America (ASA) in San Diego, Calif., October 31–November…
While typical lasers operate at only a single or handful of frequencies, laser frequency combs operate simultaneously at many frequencies, approaching a…
Astronomers have accurately measured the diameter of the faraway dwarf planet Eris for the first time by catching it as it passed in front of a faint star….
The present invention relates to antibodies that exhibit a high affinity and specificity for the A1/B-domains of CEACAM1.
Commercial Opportunities…
The present invention relates to antibodies that exhibit a high affinity and specificity for the A1/B-domains of CEACAM1.
Commercial Opportunities
CEACAM1 is an adhesion receptor molecule implicated in growth regulation and the development of cancer. It belongs to the family of carcinoembryonic antigens which forms a part of the immunoglobulin superfamily (IgSF). CEACAMs play a central role with respect to cell adhesion, differentiation, activation, proliferation, morphogenesis and apoptosis as well as receptors for various pathogens (e. g. bacteria). CEACAMs are structurally closely related: they feature the function triggering N-domain and a C-domain consisting of A- and B-domains. Due to the structural similarity it is very challenging to obtain antibodies against specific CEACAM1-domains. CEACAM1 has been detected at elevated levels in the surrounding tissue of tumors and the tumors themselves. It appears that CEACAM1 is a suitable biomarker for the diagnosis and staging of tumors.
The present invention relates to antibodies that exhibit a high affinity and mono-specificity for the A1/B-domains of human CEACAM1. Thus, they are suitable to detect the membrane anchored, the cleaved soluble CEACAM1 and most of its derivatives and may be used in various in-vitro techniques in cancer research, e.g. ELISA, WB, IHC, fluorescence microscopy and flow cytometry.
The STN partners, Chemical Abstracts Service (CAS) in the U.S. and FIZ Karlsruhe in Germany, are pleased to announce that a completely new STN will be phased…
In three recent papers, the authors report on their detailed investigations to show that a Type 1.5 superconducting state is indeed possible in a class of…
ManyThe novel combination therapy, developed at the Julius-Maximilians-Universität Würzburg, is based on a combined treatment strategy using glucocorticoids
combined with inhibitors of the proteasome . The new therapy effectively and significantly reduced edema formation and moreover significantly ameliorated neurological performance in mouse models of stroke and
brain trauma….
The current invention is based on combination therapies of nucleoside analogs with inhibitors of either the Nodal/Activin pathway or the mTOR / hedgehog…
Researchers from Ruhr-University Bochum have found a massive security gap at Amazon Cloud Services. Using different methods of attack (signature wrapping and…
The study, published today, 24 October, in IOP Publishing's journal Environmental Research Letters, is the first international survey on public perception of…
Water is an essential ingredient for life. Scientists have found thousands of Earth-oceans’ worth of it within the planet-forming disk surrounding the star TW…
Explosions in the sun’s outer atmosphere – tracked and forecast by NOAA scientists – can cause geomagnetic and solar radiation storms at Earth that can impede…
“Detailed computer simulations have shown us that the gravitational pull of a planet inside a circumstellar disk can perturb gas and dust, creating spiral…
By modifying a familiar tool in nanoscience – the Scanning Tunneling Microscope – a team at Cornell University’s Laboratory for Atomic and Solid State Physics…
The principal goal of LAGUNA (Large Apparatus for Grand Unification and Neutrino Astrophysics) is to assess the feasibility of a new pan-European research…
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