The discovery allows for a clearer understanding of the magnetism in some compounds of iron, the iron arsenides, and how it helps induce superconductivity, the…

Implantation technology allows the production of photocatalytically effective TiO2 in titanium or titanium alloy surfaces.

Brown dwarfs are objects that are too large to be called planets, yet too small to be stars. Having a mass of only less than seven per cent of the mass of the…

Simulations are a popular tool to study physical processes that cannot be investigated experimentally in detail. For example, scientists are challenged to…

Scientists at the University of Göttingen in Germany developed new and highly potent drugs with cleavable chemical linkers to develop tumor specific antibodies for selective tumor therapy (ADC). The soluble prodrugs are activated into highly cytotoxic drugs only in targeted tumor cells.

Neutron stars are the most extreme and fascinating objects known to exist in our universe: Such a star has a mass that is up to twice that of the sun but a…

Pain is probably the most common symptom and sensation of a disease, and a big individual and socioeconomic challenge. Diagnostic tools are limited and do not result in clear mechanism-based insight into the etiology of the individual pain. PET-tracers are widely used as diagnostic and therapeutic tools in several types of cancer, besides other applications of visualization in various medical indications. However, there are so far only few reports, which utilize PET-tracer and PET-scan for the detection of pain (see references). The inventors have provided proof that an established PET-tracer for use in cancer can be also utilized for the detection of pain as a second medical application. They found this tracer to be enriched at the peripheral site of pain (see figure). The amount of tracer-enrichment strongly correlated with the measured change in pain sensitivity. On behalf of the University of Cologne and of the Witten/Herdecke University, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development and evaluation.

Electron spin resonance (ESR) spectroscopy provides data about the structure and dynamics of large molecules and permits the examination of biologically-relevant systems, which play a role in the regulation of the expression of illness-related genes. However, magnetic markings must be affixed to strategically-selected points of protein structures, because most biological structures do not contain unpaired electrons.
At the University of Konstanz, a molecular structure and the corresponding process were developed, with which the incorporation of ESR markers into peptide structures are largely independent of existing amino acid residues. The incorporation of the markers can be done specifically in any protein structure. The peptide structure experiences no essential changes, which makes an examination using ESR spectroscopy possible in intracellular and in vivo fashion.

This unprecedented set of observations give us a peek into an almost entirely unexplored part of our space environment – filling a crucial gap between what…

Researchers at the University of Georgia and at Ben-Gurion University in Israel have demonstrated for the first time that nanoscale electronic components can…

Elemental carbon appears in many different modifications, including diamond, fullerenes and graphene. Their unique structural, electronic, mechanical,…

Chronic viral infections are characterized by a reduced responsiveness of T lymphocytes; a process also termed T cell exhaustion. Tumor necrosis factor alpha (TNFalpha) has been shown to be critically involved in this exhaustion process. Consequently, our invention suggests the use of anti-TNFalpha strategies, i.e. either blockade of the TNF-receptor (TNFR) binding side or its enzymatic activity by existing drugs (e.g. Infliximab, Etanercept) for the general treatment of persisting viral infections with the aim to restore T cell function. Proof for the success of this approach has been delivered by the LCMV mouse model and the in vitro treatment of HIV patients, and is in addition supported by results from studies in systems biology. On behalf of University of Bonn and University of Cologne, we are offering this opportunity for licensing. In case of interest we will be pleased to inform you about the patent status.

The increasing trend towards lightweight constructions, especially in the aerospace sector and in automotive production requires the use of new technologies, manufacturing processes and materials. FRP in particular, are frequently used in this context, due to their high stiffness and strength. The invention proposes a reliable method to weld FRP components onto other FRP components or onto metallic structures. This becomes possible by inserting metallic inserts into the composite, that serve as bridging points to enable a resistance projection welding process. A patent application has been filed in Germany. On behalf of the RWTH University, PROvendis is seeking a partner for further development in view of funding and licensing the technology.

The field of application of the new technology is the computer-based modelling of three-dimensional objects (as e.g. in a virtual space). The new technology includes a cross-device three dimensional modelling technique that will enable the development of a three-dimensional modelling system, which contains two-dimensional input devices (as e.g. mouse or touch interface) for controlling and further three-dimensional input devices.

Twisted light has raised researchers' interest for its potential for quantum communication applications. The discrete nature of one of the defining parameters…

Manganese monosilicide is a model object for spintronics – a branch of quantum electronics to study the possibility of controlling spin-polarized currents…