NTU Singapore scientists develop technique to observe radiation damage over femtoseconds

The comprehensive setup that Assoc Prof Loh from NTU Singapore used, which includes a chirped mirror compressor to generate 5-femtosecond laser pulses. This allows for the observation of radiation damage on biological tissue in a quadrillionth of a second. Credit: NTU Singapore

The technique involves dissolving organic molecules in water to simulate the state molecules are found in biological tissue. This allows the research team to see radiation damage occur in biological tissue and molecules with greater precision and clarity than ever before.

Nuclear or “ionising” radiation can damage our bodies by altering DNA and other biological molecules as it disintegrates the chemical bonds holding molecules together.

Using their new technique, the scientists watched the vibrations generated by collisions of ionising radiation particles with an organic molecule, which eventually caused it to break apart after undergoing violent stretching, bending, and twisting motions.

These vibrations only occurred when the molecules were dissolved in water, which represents a significant advance on previous studies.

Associate Professor Zhi-Heng Loh, an Assistant Chair at NTU's School of Physical & Mathematical Sciences who led the research, said, “This is the first time anyone has observed ionisation-induced molecular dynamics in aqueous solutions on femtosecond time scales. In previous studies, scientists were only able to observe the products of ionisation after the molecule had already been broken apart.”

Although the hazards of radiation have been widely recognised since the 1930s, when Marie Curie died from anaemia caused by her long-term exposure to radioactivity, the exact processes by which ionising radiation alters molecules are still not completely understood.

The study used methods from femtochemistry, to capture how atoms and molecules behave at ultra-short time scales, as in the formation or breaking of chemical bonds that take a few quadrillionths of a second, or femtoseconds.

Femtochemistry uses lasers that emit extremely brief pulses of light and each pulse creates a snapshot of the chemical reaction. These can then be stitched together like the frames of a video, to watch ultra-fast chemical processes from start to end.

Uncovering how radiation alters molecules

Assoc Prof Loh and his team set out to understand how ionising radiation affects biological molecules. As a starting point, they focused their attention on the phenoxide ion, a relatively simple organic molecule that contains many of the same types of chemical bonds that are found in the proteins that make up living tissue.

High-resolution spectroscopy had previously been used to study phenoxide in its gaseous form, and from it researchers had observed a relatively simple behaviour: when struck by ionising radiation, each phenoxide molecule vibrates at a single frequency, like a bell ringing in a single clear tone. However, this method could not be used to study organic molecules dissolved in water, which is similar to the state molecules are found in biological tissue.

Using a pulsed-laser apparatus, the NTU team was able to record how radiation damages phenoxide molecules dissolved in water. The team identified multiple vibrational frequencies, distinct from the single frequency observed in gaseous phenoxide. They discovered that when radiation causes the molecules to eject an electron, the molecule vibrates in a highly complex pattern, more akin to the sound of a cymbal or gong than a ringing bell.

“In the future, we will build on this to investigate how radiation affects larger and more complicated molecules, such as proteins and nucleic acids, which are the building blocks of life,” said Assoc Prof Loh.

“Our research group specialises in femtochemistry, and once we got interested in the topic, it turned out to be relatively simple to adapt our femtochemistry methods to studying the vibrational motion of ionised molecules dissolved in water. To our surprise, no one had ever tackled this particular problem before,” he added.


Note to Editors:

Paper titled “Ultrafast structural rearrangement dynamics induced by the photodetachment of phenoxide in aqueous solution”, published in Nature Communications on 3 July 2019.

Media contact:

Mr Nur Amin Shah
Manager, Media Relations
Corporate Communications Office
Nanyang Technological University
Email: aminshah(a.t.)ntu.edu.sg

About Nanyang Technological University, Singapore

A research-intensive public university, Nanyang Technological University, Singapore (NTU Singapore) has 33,000 undergraduate and postgraduate students in the Engineering, Business, Science, Humanities, Arts, & Social Sciences, and Graduate colleges. It also has a medical school, the Lee Kong Chian School of Medicine, set up jointly with Imperial College London.

NTU is also home to world-class autonomous institutes – the National Institute of Education, S Rajaratnam School of International Studies, Earth Observatory of Singapore, and Singapore Centre for Environmental Life Sciences Engineering – and various leading research centres such as the Nanyang Environment & Water Research Institute (NEWRI) and Energy Research Institute @ NTU (ERI@N).

Ranked 11th in the world, NTU has been placed the world's top young university for the past six years. The University's main campus is frequently listed among the Top 15 most beautiful university campuses in the world and it has 57 Green Mark-certified (equivalent to LEED-certified) building projects, of which 95% are certified Green Mark Platinum. Apart from its main campus, NTU also has a campus in Novena, Singapore's healthcare district.

For more information, visit http://www.ntu.edu.sg

Alle Nachrichten aus der Kategorie: Physics and Astronomy

This area deals with the fundamental laws and building blocks of nature and how they interact, the properties and the behavior of matter, and research into space and time and their structures.

innovations-report provides in-depth reports and articles on subjects such as astrophysics, laser technologies, nuclear, quantum, particle and solid-state physics, nanotechnologies, planetary research and findings (Mars, Venus) and developments related to the Hubble Telescope.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Hyperbolic metamaterials exhibit 2T physics

3D nonlinear ferro-fluid-based hyperbolic metamaterials may contribute to ultra-fast all-optical hyper-computing. Metamaterials–nanoengineered structures designed for precise control and manipulation of electromagnetic waves–have enabled such innovations as invisibility cloaks and super-resolution…

40% of O’ahu, Hawai’i beaches could be lost by mid-century

The reactive and piecemeal approach historically used to manage beaches in Hawai’i has failed to protect them. If policies are not changed, as much as 40% of all beaches on…

Thin and ultra-fast photodetector sees the full spectrum

Researchers have developed the world’s first photodetector that can see all shades of light, in a prototype device that radically shrinks one of the most fundamental elements of modern technology….

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.