Relay station in the brain controls our movements

Two cell populations in the substantia nigra that are responsible for different aspects of locomotion. Image: University of Basel, Biozentrum

Whether we move our arms, legs or the entire body, every movement is centrally controlled by our brain. Different brain regions and neuronal networks play an essential role in this process. This includes the substantia nigra, which has been minimally investigated so far.

Like a relay station, this region receives and distributes signals in order to appropriately orchestrate the execution of a desired movement. Using a mouse model, Prof. Kelly Tan's research group at the Biozentrum, University of Basel, has now identified two cell populations in the substantia nigra that are responsible for different aspects of locomotion.

Correct movement thanks to teamwork of neuron populations

The research team investigated the substantia nigra anatomically, genetically and functionally. It became apparent that this region consists of several different types of nerve cells.

The researchers could identify two of the populations and describe them in more detail. While one population is responsible for initiating a motor task, the second population ensures the continuity of the desired movement.

“The heterogeneity of neuronal populations in the brain, also in the substantia nigra, is a well acknowledged concept. In our study, not only we decipher the function of two nerve cell groups, but we also show that they work together to produce correct locomotion,” says Giorgio Rizzi, first author of the study.

Signals for movement control are interrupted in Parkinson’s disease

The findings of the study are also important in regard to Parkinson’s disease. Patients suffer from motor control abnormalities because certain nerve cells degenerate.

“Interestingly these cells are interaction partners of the population we identify as essential for movement initiation. This means that the signals of the cell population are no longer received and transmitted; and this dysfunction may underlie the movement initiation impairment symptom observed in Parkinson’s disease patients,” says Kelly Tan.

In the future, the research team aims to continue identifying other cell populations of the substantia nigra and elucidate their motor functions. “With regard to Parkinson's disease, we will assess how each network is altered as a result of the disease and how this affects movement.

If we understand the circuit modifications, we may find a way to tackle this neurodegenerative disorder and relieve the symptoms of Parkinson's disease patients,” states Kelly Tan.

Prof. Dr. Kelly Tan, University of Basel, Biozentrum, Tel. +41 61 207 16 26, email: kelly.tan@unibas.ch

Giorgio Rizzi and Kelly R. Tan
Synergistic Nigral Output Pathways Shape Movement
Cell Reports (2019), doi: 10.1016/j.celrep.2019.04.068
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30541-8

Media Contact

Heike Sacher Universität Basel

Weitere Informationen:

http://www.unibas.ch

Alle Nachrichten aus der Kategorie: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Is it one or two species?

The case of the cluster anemones If you dive in the Mediterranean Sea, the cluster anemone is among the most fascinating and magnificent corals you could see. You can find…

In a field where smaller is better, researchers discover the world’s tiniest antibodies

Researchers at the University of Bath in the UK and biopharma company UCB have found a way to produce miniaturised antibodies, opening the way for a potential new class of treatments for…

Researchers create artificial lung to support pre-term babies in distress

An international team led by current and former McMaster University researchers has developed an artificial lung to support pre-term and other newborn babies in respiratory distress. The group has proven…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close