Charting hidden territory of the human brain
Neuroscientists at Technische Universität Dresden discovered a novel, non-invasive imaging-based method to investigate the visual sensory thalamus, an important structure of the human brain and point of origin of visual difficulties in diseases such as dyslexia and glaucoma. The new method could provide an in-depth understanding of visual sensory processing in both health and disease in the near future.
The visual sensory thalamus is a key region that connects the eyes with the cerebral cortex. It contains two major compartments. Symptoms of many diseases are associated with alterations in this region. So far, it has been very difficult to assess these two compartments in living humans, because they are tiny and located very deep inside the brain.
This difficulty of investigating the visual sensory thalamus in detail has hampered the understanding of the function of visual sensory processing tremendously in the past. By coincidence, Christa Müller-Axt, Ph.D. student in the lab of neuroscientist Prof. Katharina von Kriegstein at TU Dresden, discovered structures that she thought might resemble the two visual sensory thalamus compartments in neuroimaging data. The neuroimaging data was unique because it had an unprecedented high spatial resolution obtained on a specialised magnetic resonance imaging (MRI) machine at the MPI-CBS in Leipzig, where the group was researching developmental dyslexia. She followed up this discovery in a series of novel experiments involving analysis of high spatial resolution in-vivo and post-mortem MRI data as well as post-mortem histology and was soon sure to have discovered the two major compartments of the visual sensory thalamus.
The results showed that the two major compartments of the visual sensory thalamus are characterised by different amounts of brain white matter (myelin). This information can be detected in novel MRI data and thus, can be used to investigate the two compartments of the visual sensory thalamus in living humans.
“The finding that we can display visual sensory thalamus compartments in living humans is fantastic, as it will be a great tool for understanding visual sensory processing both in health and disease in the near future”, claims first author Christa Müller-Axt and explains, “Post-mortem studies in developmental dyslexia have shown that there are alterations specifically in one of the two compartments of the visual sensory thalamus. However, there are very few of these post-mortem studies, so it is difficult to say whether all dyslexics are characterised by these kind of visual sensory thalamus alterations. Also, post-mortem data cannot reveal anything about the functional impact of these alterations and their specific contribution to developmental dyslexia symptoms. Therefore, we expect that our novel in-vivo approach will be a great asset in facilitating research on the role of the visual sensory thalamus in developmental dyslexia.”
Christa Müller-Axt, Cornelius Eichner, Henriette Rusch, Louise Kauffmann, Pierre-Louis Bazin, Alfred Anwander, Markus Morawski, Katharina von Kriegstein. Mapping the human lateral geniculate nucleus and its cytoarchitectonic subdivisions using quantitative MRI, NeuroImage, Volume 244, 2021, 118559. https://doi.org/10.1016/j.neuroimage.2021.118559
Method of Research: Observational study
Subject of Research: Not applicable
Article Title: Mapping the human lateral geniculate nucleus and its cytoarchitectonic subdivisions using quantitative MRI
Technische Universität Dresden
All latest news from the category: Life Sciences and Chemistry
Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Under arrest: Using nanofibers to stop brain tumor cells from spreading
Researchers from Japan develop a platform based on nanofibers to trap brain cancer cells as a therapeutic strategy. Our body heals its injuries by essentially replacing damaged cells with new…
New photonic chip for isolating light may be key to miniaturizing quantum devices
Light offers an irreplaceable way to interact with our universe. It can travel across galactic distances and collide with our atmosphere, creating a shower of particles that tell a story…
A traffic light for light-on-a-chip
Integrated photonics allow us to build compact, portable, low-power chip-scale optical systems used in commercial products, revolutionizing today’s optical datacenters and communications. But integrating on-chip optical gain elements to build…