Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fraunhofer FIT at MEDICA and COMPAMED: Electrowetting and Telemedicine

23.10.2018

At MEDICA Fraunhofer FIT presents the teliFIT platform for telemedicine and telecoaching, a modular system that can be tailored to a wide range of application requirements and guarantees a very high level of data security. At COMPAMED we present our EWOD-BioPro system that combines electrowetting and confocal microscopy and thus makes it possible to observe the process of biochemical reactions at the single-molecule level.

An important aspect of pharmacology is to understand how active drug ingredients cross-react with endogenous molecules. But until now, such reactions could only be determined after the event. The precise details of the interacting factors remained unclear.


The EWOD-BioPro Electrowetting-On-Dielectric system can help to better understand biological mechanisms and interactions.

© Fraunhofer FIT

Researchers at Fraunhofer FIT have developed a system that now allows monitoring biochemical reactions at the single-molecule level from start to finish. It is based on the physical effect of Electrowetting-On-Dielectric (EWOD), widely used in micro-fluidics.

Our EWOD-BioPro system is capable of merging reagent droplets as small as 150nl with very high precision. This allows us to monitor the reaction process using a confocal microscope adapted at FIT, and to record high-resolution measurements.

"For the first time we can observe the details of how the two droplets interact at the single-molecule level – thus allowing us to monitor the entire chain of events," says Lorenz Sparrenberg from the Fraunhofer Institute for Applied Information Technology FIT, who is leading the research project.

Thus, we can study biological interactions under conditions closely resembling those that occur naturally in the human body. In pharmacology, for example, it is important to understand the effects of drug ingredients as precisely as possible and know when these effects occur.

But the combination of EWOD and confocal microscopy may also be used to study the interaction between complementary DNA strands, antibodies and antigens, or enzyme-substrate reactions.

Conventional laboratory tests not only deliver less information but also require much higher quantities of the sample liquids, and take longer to perform. The typical duration of an enzymatic assay, for example, is around 15 – 20 minutes. The EWOD-BioPro system can present the results within 30 seconds. It may thus be a further step

towards point-of-care diagnostics, where test are carried out at the bedside in hospitals or in the physician's office instead of sending samples to a central laboratory.

The EWOD-BioPro system will be presented at COMPAMED, in Düsseldorf, 12 – 15 November 2018, hall 8a, booth P13.

>>teliFIT – Intelligent platform for telemedicine and telecoaching

The teliFIT platform features a modular, expandable architecture. It can accommodate a multitude of user groups with their specific access rights and can easily be tailored to a wide range of design requirements, contents and functions. The platform's current functionalities may be grouped in five categories: Communication, Monitoring, Analysis, Smart Data Services and Safety & Security. Individual functions can be activated or extended as required.

Smart devices can be used to capture and upload data to the teliFIT platform. Processing results are presented in visually attractive charts, but also offer relevant context. For example, teliFIT offers a nutrition diary that automatically evaluates the calories taken in against the user's individual basic requirement. Actual intake is also evaluated in relation to agreed nutritional goals.

Data security has been a major design criterion for the teliFIT platform. Personal data is routinely encrypted and stored in a separate database. The teliFIT platform is hosted in Germany. Its resilience is checked regularly through external penetration tests. There is a stable code base that includes high quality software and architecture. Due to the use of state-of-the-art software technologies, the platform is easily scalable.

The teliFIT platform will be presented at MEDICA in Düsseldorf, 12 – 15 November 2018 (Fraunhofer-Gemeinschaftsstand, hall 10, booth G05).

Alex Deeg | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Further information:
http://www.fit.fraunhofer.de

More articles from Trade Fair News:

nachricht Medica 2019: Arteriosclerosis - new technologies help to find proper catheters and location of vasoconstriction
11.11.2019 | Technische Universität Kaiserslautern

nachricht Laser versus weeds: LZH shows Farming 4.0 at the Agritechnica
08.11.2019 | Laser Zentrum Hannover e.V.

All articles from Trade Fair News >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Machine learning microscope adapts lighting to improve diagnosis

Prototype microscope teaches itself the best illumination settings for diagnosing malaria

Engineers at Duke University have developed a microscope that adapts its lighting angles, colors and patterns while teaching itself the optimal...

Im Focus: Small particles, big effects: How graphene nanoparticles improve the resolution of microscopes

Conventional light microscopes cannot distinguish structures when they are separated by a distance smaller than, roughly, the wavelength of light. Superresolution microscopy, developed since the 1980s, lifts this limitation, using fluorescent moieties. Scientists at the Max Planck Institute for Polymer Research have now discovered that graphene nano-molecules can be used to improve this microscopy technique. These graphene nano-molecules offer a number of substantial advantages over the materials previously used, making superresolution microscopy even more versatile.

Microscopy is an important investigation method, in physics, biology, medicine, and many other sciences. However, it has one disadvantage: its resolution is...

Im Focus: Atoms don't like jumping rope

Nanooptical traps are a promising building block for quantum technologies. Austrian and German scientists have now removed an important obstacle to their practical use. They were able to show that a special form of mechanical vibration heats trapped particles in a very short time and knocks them out of the trap.

By controlling individual atoms, quantum properties can be investigated and made usable for technological applications. For about ten years, physicists have...

Im Focus: Images from NJIT's big bear solar observatory peel away layers of a stellar mystery

An international team of scientists, including three researchers from New Jersey Institute of Technology (NJIT), has shed new light on one of the central mysteries of solar physics: how energy from the Sun is transferred to the star's upper atmosphere, heating it to 1 million degrees Fahrenheit and higher in some regions, temperatures that are vastly hotter than the Sun's surface.

With new images from NJIT's Big Bear Solar Observatory (BBSO), the researchers have revealed in groundbreaking, granular detail what appears to be a likely...

Im Focus: New opportunities in additive manufacturing presented

Fraunhofer IFAM Dresden demonstrates manufacturing of copper components

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM in Dresden has succeeded in using Selective Electron Beam Melting (SEBM) to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

High entropy alloys for hot turbines and tireless metal-forming presses

05.11.2019 | Event News

 
Latest News

Designer lens helps see the big picture

21.11.2019 | Interdisciplinary Research

Machine learning microscope adapts lighting to improve diagnosis

21.11.2019 | Life Sciences

Soft skin-like robots you can put in your pocket

21.11.2019 | Interdisciplinary Research

VideoLinks
Science & Research
Overview of more VideoLinks >>>