Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NMR - The movie

25.02.2003


Ten construction workers will often get a job done faster than one. But in digging a deep well, for instance, ten workers are a waste of human resources: the diggers can’t work simultaneously, as the second worker isn’t able to start digging until the first one has finished, and so on.



A similar challenge is encountered by scientists who study the structure and dynamics of molecules using nuclear magnetic resonance (NMR) spectroscopy. This technique serves as an essential tool in understanding numerous molecules – including proteins, nucleic acids and active pharmaceuticals – in their natural surroundings. It does this by exposing them to electromagnetic radiation and studying the dispersion patterns of the electromagnetic waves that hit the molecules. However, to obtain a full NMR picture of such complex molecules one needs to perform numerous measurements that are based on the same “serial” principle as well digging: hundreds or thousands of one-dimensional scans need to be performed one after the other; these scans need then to be combined to create a unified multidimensional picture of the molecule. While a single scan may take a fraction of a second, multidimensional procedures may last several hours or even days.

A team led by Prof. Lucio Frydman of the Weizmann Institute’s Chemical Physics Department has now found a way to perform multidimensional NMR with a single scan. The new method, described in the December 2002 issue of the Proceedings of the National Academy of Sciences USA (PNAS), is expected to significantly speed up molecular studies routinely performed in diverse fields.


The method “slices” a sample into numerous thin slices and then simultaneously performs all the measurements required by multidimensional NMR – lasting a fraction of a second each – on every one of these slices. The system then integrates all the measurements according to their precise location, generating an image that amounts to a multi-dimensional spectrum from the entire sample. Essentially, Prof. Frydman has found a way to allow NMR “well diggers” to work simultaneously.

Scientists will now be able to observe rapid changes taking place in molecules, such as the folding of proteins. In this sense, the new method developed by Prof. Frydman amounts to a transition from taking still “NMR photos” to recording “NMR movies.”

Prof. Frydman’s method may also have a great impact on the design of new drugs and the development of catalysts, particularly in the emerging fields of combinatorial chemistry and of metabonomics.


Contributing to this research were Dr. Adonis Lupulescu of the Chemical Physics Department and Dr. Tali Scherf of Chemical Services at the Weizmann Institute of Science.

Prof. Lucio Frydman’s research is supported by the Abraham and Sonia Rochlin Foundation, the Henri Gutwirth Fund for Research, the Philip M. Klutznick Fund, the late Ilse Katz, Switzerland, and Minerva Stiftung Gesellschaft fuer die Forschung m.b.H.

Alex Smith | EurekAlert!
Further information:
http://www.weizmann.ac.il/

More articles from Physics and Astronomy:

nachricht Smallest transistor worldwide switches current with a single atom in solid electrolyte
17.08.2018 | Karlsruher Institut für Technologie (KIT)

nachricht Protecting the power grid: Advanced plasma switch for more efficient transmission
17.08.2018 | DOE/Princeton Plasma Physics Laboratory

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>