Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NYU Physicists Devise Method for Building Artificial Tissue

29.05.2012
New York University physicists have developed a method that models biological cell-to-cell adhesion that could also have industrial applications.

This system, created in the laboratory of Jasna Brujiæ, an assistant professor in NYU’s Department of Physics and part of its Center for Soft Matter Research, is an oil-in-water solution whose surface properties reproduce those found on biological cells.

Specifically, adhesion between compressed oil droplets mimics the mechanical properties of tissues and opens the path to numerous practical applications, ranging from biocompatible cosmetics to artificial tissue engineering.

Their method is described in the journal the Proceedings of the National Academy of Sciences.

Previously, Brujiæ’s laboratory has determined how spheres pack and devised methods for manipulating the packing process. In this PNAS study, Brujiæ and her research team sought to create a method that would address the role of packing in tissues from the point of view of how mechanical forces affect protein-protein adhesion between cells.

In biology, cell-to-cell adhesion is crucial to the integrity of tissue structure—cells must come together and stick in order to ensure tissue cohesion. However, the daunting complexity of biological systems has long prevented their description using general theoretical concepts taken from the physical sciences. For this reason, the research team designed an original biomimetic solution, or emulsion, that reproduces the main features of cell-to-cell adhesion in tissues.

Emulsions form the basis for a range of consumer products, including butter, ice cream, and milk. In addition, the emulsion in the PNAS study is tuned to match the attractive and repulsive interactions that govern adhesion between cells. The experimental conditions reveal the circumstances under which pushing forces are necessary to create adhesion.

By varying the amount of force by which the droplets of oil were compressed by centrifugation and the amount of salt added to this solution, the NYU team was able to isolate the optimal conditions for cell-to-cell adhesion. Screening electrostatic charges by the addition of salt and compressing the droplets by force enhances protein-protein interactions on the droplet surfaces. This leads to adhesion between contacting droplets covering all the interfaces, just as in the case of biological tissues.

Their results, which matched the researchers’ theoretical modeling of the process, offer a method for manipulating force and pressure in order to bind emulsions. This serves as a starting point for enriching a range of consumer products, by reconfiguring their molecular make-up to enhance consistency and function, and for improving pharmaceuticals, by bolstering the delivery of therapeutic molecules to the blood stream.

The study’s other authors were Lea-Laetitia Pontani, a postdoctoral research scientist, and Ivane Jorjadze, a graduate student, both from NYU’s Department of Physics and the Center for Soft Matter Research, as well as Virgile Viasnoff, an Associate Professor at the National University of Singapore and the French research institute, CNRS/ESPCI.

For more on the Brujiæ Laboratory, go to http://www.physics.nyu.edu/~jb2929/index.html; for more on the Center for Soft Matter Research, go to http://csmr.as.nyu.edu/page/home.

The research was performed in the NYU Materials Research Science and Engineering Center (MRSEC), which is supported by the National Science Foundation.

James Devitt | Newswise Science News
Further information:
http://www.nyu.edu

More articles from Physics and Astronomy:

nachricht Convenient location of a near-threshold proton-emitting resonance in 11B
29.05.2020 | The Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences

nachricht A special elemental magic
28.05.2020 | Kyoto University

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Biotechnology: Triggered by light, a novel way to switch on an enzyme

In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".

Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

Im Focus: I-call - When microimplants communicate with each other / Innovation driver digitization - "Smart Health“

Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.

When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...

Im Focus: When predictions of theoretical chemists become reality

Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.

Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...

Im Focus: Rolling into the deep

Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

Black nitrogen: Bayreuth researchers discover new high-pressure material and solve a puzzle of the periodic table

29.05.2020 | Materials Sciences

Argonne researchers create active material out of microscopic spinning particles

29.05.2020 | Materials Sciences

Smart windows that self-illuminate on rainy days

29.05.2020 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>