Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Photoactive bacteria bait may help in fight against MRSA infections

12.10.2018

Purdue researchers find light-active version of heme may help people infected with MRSA

Purdue University researchers are testing whether a light-active version of heme, the molecule responsible for transporting oxygen in blood circulation, may help people infected with MRSA.


Purdue University researchers are testing whether a simple light-emitting diode array that is safe to use on human skin can be used to inactivate methicillin-resistant Staphylococcus aureus, or MRSA, one of six 'high priority' pathogens that the World Health Organization has identified as an imminent threat to public health. Here the light shines above a 96-well plate in a bio-safety hood.

Credit: Purdue Research Foundation image/John Underwood

MRSA led

Purdue University researchers are testing whether a simple light-emitting diode array that is safe to use on human skin can be used to inactivate methicillin-resistant Staphylococcus aureus, or MRSA, one of six 'high priority' pathogens that the World Health Organization has identified as an imminent threat to public health. Here the light shines above a 96-well plate in a bio-safety hood. (Purdue Research Foundation photo/John Underwood) Download image

The research was published in the American Chemical Society journal ACS Infectious Diseases in September. A link to the article is here.

The World Health Organization identifies MRSA as one of about a dozen antibiotic "superbugs" that pose an enormous threat to human health.

WHO has listed methicillin-resistant Staphylococcus aureus, or MRSA, as one of six 'high priority' pathogens with an imminent threat to public health. The Centers for Disease Control and Prevention reports 80,461 people in the United States suffer severe MRSA infections a year and 11,285 die.

Anyone can get MRSA on their body from contact with an infected wound, or by sharing personal items such as towels or razors that are contaminated. However, patients in hospitals are especially vulnerable to MRSA infections.

"MRSA infections can cause severe problems for patients recovering from surgery," said Alexander Wei, a professor of chemistry in the College of Science who is leading the research team. "The challenge that we face is that MRSA responds poorly to multiple antibiotics. Antimicrobial photodynamic therapy offers a promising alternative for combating MRSA in infected wounds."

Photodynamic therapy, or PDT, involves a compound known as a photosensitizer, which can be activated by visible light to kill diseased cells or bacteria. PDT is a clinically proven method for fighting cancer but has not yet been developed for treating MRSA infections.

The discovery aligns with Purdue's Giant Leaps celebration, recognizing the university's global advancements made in health, longevity and quality of life as part of Purdue's 150th anniversary. This is one of the four themes of the yearlong celebration's Ideas Festival, designed to showcase Purdue as an intellectual center solving real-world issues.

The photosensitizer developed at Purdue is called Ga-PpIX, and is an analog of heme. Ana Morales-de-Echegaray, the lead graduate research assistant on the project at the time, discovered that Ga-PpIX could be gobbled up by MRSA strains within seconds, leading to their rapid inactivation using a simple light-emitting diode (LED) array that is safe to use on human skin.

"Our discovery is part of a convergence on campus to develop drugs and get them to people in need as quickly as possible," Wei said.

Wei and his collaborator Mohamed Seleem, a professor in Purdue's College of Veterinary Medicine, are working closely with the Purdue Institute of Inflammation, Immunology and Infectious Disease and the Purdue Institute for Drug Discovery to determine if this kind of treatment could work for animals and with other types of skin infection.

The technology is patented through Purdue Office of Technology Commercialization, and the researchers are looking for partners to continue developing practical applications for the discovery.

###

About the Purdue Office of Technology Commercialization

The Purdue Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university's academic activities. The office is managed by the Purdue Research Foundation, which received the 2016 Innovation and Economic Prosperity Universities Award for Innovation from the Association of Public and Land-grant Universities. For more information about funding and investment opportunities in startups based on a Purdue innovation, contact the Purdue Foundry at foundry@prf.org. For more information on licensing a Purdue innovation, contact the Office of Technology Commercialization at otcip@prf.org. The Purdue Research Foundation is a private, nonprofit foundation created to advance the mission of Purdue University.

Writer: Zeina Kayyali, zmkayyali@prf.org

Purdue Research Foundation contact: Chris Adam, 765-588-3341, cladam@prf.org

Source: Alexander Wei, alexwei@purdue.edu

Note to Journalists: For a full-text copy of the paper, please contact Tom Coyne, Purdue Research Foundation, at tjcoyne@prf.org

Media Contact

Tom Coyne
tjcoyne@prf.org
765-588-1044

 @PurdueUnivNews

http://www.purdue.edu/ 

 

Tom Coyne | EurekAlert!
Further information:
https://www.purdue.edu/newsroom/releases/2018/Q4/purdue-researchers-hope-deadly-mrsa-superbugs-take-the-bait.html
http://dx.doi.org/10.1021/acsinfecdis.8b00125

More articles from Health and Medicine:

nachricht Candidate Ebola vaccine still effective when highly diluted, macaque study finds
21.10.2019 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Autism spectrum disorder risk linked to insufficient placental steroid
21.10.2019 | Children's National Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers watch quantum knots untie

After first reporting the existence of quantum knots, Aalto University & Amherst College researchers now report how the knots behave

A quantum gas can be tied into knots using magnetic fields. Our researchers were the first to produce these knots as part of a collaboration between Aalto...

Im Focus: A cavity leads to a strong interaction between light and matter

Researchers have succeeded in creating an efficient quantum-mechanical light-matter interface using a microscopic cavity. Within this cavity, a single photon is emitted and absorbed up to 10 times by an artificial atom. This opens up new prospects for quantum technology, report physicists at the University of Basel and Ruhr-University Bochum in the journal Nature.

Quantum physics describes photons as light particles. Achieving an interaction between a single photon and a single atom is a huge challenge due to the tiny...

Im Focus: Solving the mystery of quantum light in thin layers

A very special kind of light is emitted by tungsten diselenide layers. The reason for this has been unclear. Now an explanation has been found at TU Wien (Vienna)

It is an exotic phenomenon that nobody was able to explain for years: when energy is supplied to a thin layer of the material tungsten diselenide, it begins to...

Im Focus: An ultrafast glimpse of the photochemistry of the atmosphere

Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have explored the initial consequences of the interaction of light with molecules on the surface of nanoscopic aerosols.

The nanocosmos is constantly in motion. All natural processes are ultimately determined by the interplay between radiation and matter. Light strikes particles...

Im Focus: Shaping nanoparticles for improved quantum information technology

Particles that are mere nanometers in size are at the forefront of scientific research today. They come in many different shapes: rods, spheres, cubes, vesicles, S-shaped worms and even donut-like rings. What makes them worthy of scientific study is that, being so tiny, they exhibit quantum mechanical properties not possible with larger objects.

Researchers at the Center for Nanoscale Materials (CNM), a U.S. Department of Energy (DOE) Office of Science User Facility located at DOE's Argonne National...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Symposium on Functional Materials for Electrolysis, Fuel Cells and Metal-Air Batteries

02.10.2019 | Event News

NEXUS 2020: Relationships Between Architecture and Mathematics

02.10.2019 | Event News

Optical Technologies: International Symposium „Future Optics“ in Hannover

19.09.2019 | Event News

 
Latest News

Composite metal foam outperforms aluminum for use in aircraft wings

23.10.2019 | Materials Sciences

Researchers watch quantum knots untie

23.10.2019 | Physics and Astronomy

A technology to transform 2D planes into 3D soft and flexible structures

23.10.2019 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>