More than a nice coating

A perineuronal net (in green) with synapses embedded in it (in red) Credit: Daniela Carulli

PERINEURONAL NETS INFLUENCE LEARNING

As the brain becomes older, the contacts between nerve cells (synapses) become less flexible, because they are encased in a meshwork of proteins and carbohydrates called a perineuronal net.

In the current study, researchers of the NIN (Verhaagen group and De Zeeuw group), in collaboration with the University of Turin and the University of Cambridge, induced a remarkable remodeling of cerebral synapses.

They improved the learning abilities of mice by using a powerful molecular tool to degrade the perineuronal nets. However, the capability of the mice to remember what they had learned was disturbed, indicating that the storage of acquired information requires intact perineuronal nets.

“This is the first time that it has been shown that changes in perineuronal nets are instrumental for motor learning and memory”, says Daniela Carulli, researcher at the NIN and first author of this study.

CHANGING OF PERINEURONAL NETS

Children have the capability to learn much better than adults, from mastering a new language to playing a musical instrument. This is possible thanks to the flexibility (or “plasticity”) of the connections between nerve cells in young brains.

Plasticity also allows a faster recovery from brain injury. “We discovered that perineuronal nets exert tight control on learning and memory in the adult brain”, explains Carulli.

The researchers investigated a well-characterized type of learning, called eyeblink conditioning, that depends on the cerebellum, a brain region involved in motor functions.

“Our results indicate that perineuronal nets are diminished during the learning phase of eyeblink conditioning, but are restored at later stages, when memories are consolidated”, Carulli continues.

Much still needs to be known as to how exactly perineuronal nets regulate plasticity, and, thereby cognitive functions. This is crucial in view of finding therapeutic strategies to tackle cognitive decline in the elderly or in patients with neurological disorders.

Media Contact

Daniela Carulli
d.carulli@nin.knaw.nl
31-205-665-512

http://www.nin.knaw.nl/ 

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors