Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists Found Novel Way To "Switch on" Tumour Suppressors That Have Been Silenced

11.10.2013
Latest findings by scientists from CSI at NUS and Harvard Stem Cell Institute show that RNA inhibits DNA methylation, offering strategies for treatment of diseases such as cancer

A team of scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) and their collaborators from the Harvard Stem Cell Institute have found that a novel noncoding ribonucleic acid (RNA) offers the potential for "switching on" of tumour suppressors that have been shut off.

The research group, led by Professor Daniel Tenen, Director of CSI Singapore, demonstrated for first time that RNA interacts with an enzyme essential for DNA methylation, known as DNA methyl transferase 1 (DNMT1), offering strategies for the treatment of diseases such as cancer.

In this study, the researchers focused on a new class of RNAs, which is critical in regulating DNA methylation. This is a process in which certain building blocks of DNA, the genetic code, are chemically modified without resulting in a change in the code itself. DNA methylation is associated with silencing of gene expression and found in many diseases. For example, in cancer, genes called tumour suppressors, which inhibit tumour formation, are often silenced or shut off in the cancer cells, and this is associated with DNA methylation.

This novel study was first published online in the research journal Nature on 9 October 2013.

How the novel noncoding RNA inhibits DNA methylation

The study focused on this novel noncoding RNA in a specific tumour suppressor, known as CEBPA. The silencing of CEPBA is associated with Acute Myeloid Leukemia, lung cancer and other types of cancer. The scientists demonstrated that the noncoding RNA binds to the enzyme DNMT1 and prevents DNA methylation of the CEBPA gene. This principle, which is likely to extend to thousands of other genes, can potentially be used to "switch on" tumour suppressors that have been shut off.

Prof Tenen said, “We started out by studying the noncoding RNA to satisfy our scientific curiosity. In the process, we discovered the novel finding that RNA inhibits methylation and experimentally, we can introduce RNAs to ‘switch on’ tumour suppressors which have been shut off. Our results suggest strategies for gene-selective demethylation of therapeutic targets in human diseases such as cancer.”

Further Research

In the next phase of their research, the scientists will look into developing tools for targeted activation of other tumour suppressors, besides CEBPA, and investigate the role of RNA in regulating other epigenetic marks.

Kimberley Wang | Newswise
Further information:
http://www.nus.edu.sg

More articles from Life Sciences:

nachricht Drug discovery: First rational strategy to find molecular glue degraders
03.08.2020 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

nachricht Chlamydia: Greedy for Glutamine
03.08.2020 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: TU Graz Researchers synthesize nanoparticles tailored for special applications

“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.

Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...

Im Focus: Tailored light inspired by nature

An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.

Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...

Im Focus: NYUAD astrophysicist investigates the possibility of life below the surface of Mars

  • A rover expected to explore below the surface of Mars in 2022 has the potential to provide more insights
  • The findings published in Scientific Reports, Springer Nature suggests the presence of traces of water on Mars, raising the question of the possibility of a life-supporting environment

Although no life has been detected on the Martian surface, a new study from astrophysicist and research scientist at the Center for Space Science at NYU Abu...

Im Focus: Manipulating non-magnetic atoms in a chromium halide enables tuning of magnetic properties

New approach creates synthetic layered magnets with unprecedented level of control over their magnetic properties

The magnetic properties of a chromium halide can be tuned by manipulating the non-magnetic atoms in the material, a team, led by Boston College researchers,...

Im Focus: A new method to significantly increase the range and stability of optical tweezers

Scientists of Tomsk Polytechnic University jointly with a team of the V.E. Zuev Institute of Atmospheric Optics of the Siberian Branch of the Russian Academy of Sciences have discovered a method to increase the operation range of optical traps also known

Optical tweezers are a device which uses a laser beam to move micron-sized objects such as living cells, proteins, and molecules. In 2018, the American...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“Conference on Laser Polishing – LaP 2020”: The final touches for surfaces

23.07.2020 | Event News

Conference radar for cybersecurity

21.07.2020 | Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

 
Latest News

Novel approach improves graphene-based supercapacitors

03.08.2020 | Information Technology

Germany-wide rainfall measurements by utilizing the mobile network

03.08.2020 | Information Technology

Drug discovery: First rational strategy to find molecular glue degraders

03.08.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>