Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rational Design of Engineered Arginine Depleting Enzymes as Multi-potent Anti-cancer Agents

23.09.2016

A novel multi-potent drug removes arginine from the blood and kills cancer cells.

Arginine deprivation has become a new cancer treatment paradigm and has exploited for treatment of various cancers. Arginine is an essential amino acid for the growth of cancer cells. Deprivation of arginine induces cancer cells death but it is generally well tolerated in normal cells.


Three dimensional molecular structure of thermostable Bacillus arginase (BCA).

Copyright : PolyU

The successful use of Arginine Deiminase (ADI) to treat argininosuccinate synthetase (ASS)-deficient tumors has opened up new possibilities for targeted therapy. Nevertheless, many ASSpositive cancers are resistance to ADI.

By rational drug design, researchers at The Hong Kong Polytechnic University (PolyU) have developed a thermostable arginase (BCA-PEG20) to treat both ADI-sensitive and ADI-resistant cancers.

BCA-PEG20 has demonstrated to have antitumor activities both in vitro and in vivo in lung cancer, liver cancer, colorectal cancer, gastric cancer, cervical cancer and other tumors.

As a novel multipotent anti-cancer drug, BCA-PEG20 is able to work as a single agent and combine with other chemotherapeutic agents to enhance treatment effect.

Special Features
• BCA-PEG20 is safe and effective
• BCA-PEG20 can treat drug-resistant cancers
• BCA-PEG20 can augment the therapeutic effect of other chemotherapeutic agents

Applications
• As a multipotent targeted therapy for cancers that are auxotrophic for arginine
• As a “chemo-enhancer” to augment the effect of other chemotherapeutic agents

Prize of the State of Geneva (April 2009)
• Gold Award with the congratulations of the jury - 37th International Exhibition of I nventions, New Techniques and Products, Geneva (April 2009)
• Finalist Award- SEED Competition, China (2010)

Principal Investigator
Prof. Yun-chung LEUNG and Dr Wai-hung LO
Department of Applied Biology and Chemical Technology
The Hong Kong Polytechnic University
Contact Details:
Institute for Entrepreneurship
Tel: (852) 3400 2929 Fax: (852) 2333 2410 Email: pdadmin@polyu.edu.hk

Associated links

The Hong Kong Polytechnic University | Research SEA
Further information:
http://www.researchsea.com

More articles from Life Sciences:

nachricht Nonstop Tranport of Cargo in Nanomachines
20.11.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik

nachricht Researchers find social cultures in chimpanzees
20.11.2018 | Universität Leipzig

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nonstop Tranport of Cargo in Nanomachines

Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.

Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

Nonstop Tranport of Cargo in Nanomachines

20.11.2018 | Life Sciences

Researchers find social cultures in chimpanzees

20.11.2018 | Life Sciences

When AI and optoelectronics meet: Researchers take control of light properties

20.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>