Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Alternative methods to animal testing: VISION - A microfluidic chip system as an alternative to animal experiments

13.07.2020

Since mid-2019, the Fraunhofer Institute for Biomedical Engineering IBMT has been developing an analysis platform as an alternative to animal experiments in drug development as partner in the BMBF-funded project "VISION", coordinated by Saarland University.

Animals as model organisms have so far often been essential for pharmaceutical research - they often provide important information on the efficacy of drugs or the safety of chemicals to humans.


Microfluidic chip system for the cultivation of different cell models under physiologically relevant conditions.

Bernd Müller / Fraunhofer IBMT

The protection of animals is opposed to the need to provide safe and appropriate medicines for humans.

In Germany and at the EU level there are strict legal restrictions on animal experiments. Suitable alternative methods should help to reduce and avoid animal experiments.

The Federal Ministry of Education and Research supports the development of alternative methods by funding around 600 scientific projects since 1980 with a total funding volume of more than 190 million euros

Microfluidic chips and analysis systems as an important contribution to animal welfare

These days, scientists are researching on so-called microphysiological systems that simulate and interlink various organ systems of the human body, such as the liver, lung, kidney or nerve cells.

In this context, the BMBF project "VISION", launched in June 2019, aims to reduce animal experiments by developing a special analysis platform. It consists of the combination of a microfluidic organ culture system (in vitro) and bioinformatic (in silico) analyses of disease mechanisms.

"VISION" develops and validates the in vitro/in silico analysis platform especially for toxicological inhalation studies, which could reduce animal testing in regulatory, application-oriented and basic research. At the same time, the microfluidic chip system creates new possibilities for mimicking various cell and tissue types in vitro in order to generate biological, pharmacological and toxicological data for in silico method development under physiologically relevant conditions.

Biomedical engineering as well as biological-medical and pharmaceutical science from Saarland are closely cooperating to develop the "VISION" analysis platform based on a combination of (a) an in vitro lung-liver model, (b) bioinformatic analysis methodology and (c) the integration of clinical data, which enables detailed biological, pharmacological and toxicological analysis.

Within the framework of the joint project, the Fraunhofer Institute for Biomedical Engineering IBMT has taken on the task of developing and optimizing sensitive in vitro systems (lung model and liver model) for mimicking the lung barrier and the metabolism process in the liver and their integration into microfluidic systems to determine specific effects of pollutants or therapeutic agents after pulmonary uptake into the organism.

Using these methods, meaningful in vitro analyses are performed to generate well-founded data sets as a basis for the development of the in silico model.

In "VISION", the two consortium partners combine their respective expertise. The Fraunhofer IBMT contributes in particular with the production of the microfluidic chip system and the human toxicological analysis systems connected to it.

Saarland University, Medical Clinic V, is coordinator of the project, contributes clinical data and is particularly concerned with questions of cell biology and specific disease models, such as COPD. The Faculty of Pharmacy at Saarland University is developing the bioinformatic analysis methods.

Project funding: BMBF, No. 031L0153B

Duration: 06/2019-05/2021

Project partners (Germany):
Saarland University (coordination), Clinic for Internal Medicine V, Prof. Dr. Dr. Robert Bals
Saarland University, Clinical Pharmacy, Prof. Dr. Thorsten Lehr
Fraunhofer Institute for Biomedical Engineering IBMT

Wissenschaftliche Ansprechpartner:

Project manager at the Fraunhofer IBMT:
Prof. Dr. Heiko Zimmermann
Head of Institute
Phone: +49 6897 9071 100
E-Mail: heiko.zimmermann@ibmt.fraunhofer.de

Contact at the Fraunhofer IBMT:
Dr. Yvonne Lydia Kohl
Group Manager Nanotoxicology
Phone: +49 6897 9071 256
E-Mail: yvonne.kohl@ibmt.fraunhofer.de

Weitere Informationen:

https://www.ibmt.fraunhofer.de

Dipl.-Phys. Annette Maurer-von der Gathen | Fraunhofer-Institut für Biomedizinische Technik IBMT

Further reports about: BMBF IBMT VISION bioinformatic analysis microfluidic chip

More articles from Life Sciences:

nachricht Turning carbon dioxide into liquid fuel
06.08.2020 | DOE/Argonne National Laboratory

nachricht Tellurium makes the difference
06.08.2020 | Friedrich-Schiller-Universität Jena

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: ScanCut project completed: laser cutting enables more intricate plug connector designs

Scientists at the Fraunhofer Institute for Laser Technology ILT have come up with a striking new addition to contact stamping technologies in the ERDF research project ScanCut. In collaboration with industry partners from North Rhine-Westphalia, the Aachen-based team of researchers developed a hybrid manufacturing process for the laser cutting of thin-walled metal strips. This new process makes it possible to fabricate even the tiniest details of contact parts in an eco-friendly, high-precision and efficient manner.

Plug connectors are tiny and, at first glance, unremarkable – yet modern vehicles would be unable to function without them. Several thousand plug connectors...

Im Focus: New Strategy Against Osteoporosis

An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.

Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women...

Im Focus: AI & single-cell genomics

New software predicts cell fate

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...

Im Focus: TU Graz Researchers synthesize nanoparticles tailored for special applications

“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.

Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...

Im Focus: Tailored light inspired by nature

An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.

Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“Conference on Laser Polishing – LaP 2020”: The final touches for surfaces

23.07.2020 | Event News

Conference radar for cybersecurity

21.07.2020 | Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

 
Latest News

Rare Earth Elements in Norwegian Fjords?

06.08.2020 | Earth Sciences

Anode material for safe batteries with a long cycle life

06.08.2020 | Power and Electrical Engineering

Turning carbon dioxide into liquid fuel

06.08.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>