Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Eva-Maria and Eckhard Mandelkow have been awarded the Potamkin Prize

15.04.2011
Targets for Alzheimer therapy

Drs Eva-Maria and Eckhard Mandelkow, researchers at the Max Planck Unit for Structural Molecular Biology at DESY (Hamburg) and at the German Center for Neurodegenerative Diseases (DZNE) in Bonn, have been honored with the Potamkin Prize from the American Academy of Neurology (AAN) for their contributions to the field of dementia research.

The award ceremony takes place on 14 April at the Annual Meeting of the AAN in Honolulu (Hawaii). Eva-Maria and Eckhard Mandelkow share the prize, endowed with 100 000 U.S. dollars, with Dennis Dickson (Mayo Clinic, Jacksonville, Florida). The Potamkin Prize is one of the most prestigious awards in the field of dementia research. Since 1988, this important scientific honor is donated by the Potamkin entrepreneurial family from New York.

Together with their team, Eva-Maria and Eckhard Mandelkow have achieved major breakthroughs in Alzheimer research through their work on a protein termed tau. In the normal state tau strengthens the cytoskeleton in neurons and is involved in the transport of cell organelles. But very early in Alzheimer's disease it changes, becomes detached from the cytoskeleton and lumps together as cellular debris.

In their seminal work Eva-Maria and Eckhard Mandelkow investigated the mechanism of pathological tau aggregation and showed which parts of the protein are crucial for this process. Insights from this research then allowed them to investigate the consequences of tau protein aggregation in nerve cells in more detail using mouse and cellular models. The result showed that only forms of tau that are capable of aggregation destroy the synapses of nerve cells. If these forms of tau accumulate in neurons the mice perform poorly in learning and memory tests, thus showing typical symptoms of Alzheimer's disease. If the production of toxic tau in the cells of the mice is halted, synapses regenerate and the mice recover from their memory disorder. This crucial observation shows that the disease process is in principle reversible. With this work Eva-Maria and Eckhard Mandelkow provide an important starting point for the development of potential therapies. Their investigations on tau structure and their mouse experiments now allow the identification of drugs that counteract the toxic properties of tau and - at least in mice - can combat cognitive impairment.

Dr. Eckhard Mandelkow studied physics and earned his doctorate at the Max Planck Institute for Medical Research in Heidelberg on the structure of virus proteins. In his postdoctoral training at Brandeis University (Massachusetts, USA) he looked into proteins of the cytoskeleton and then continued this line of research with a focus on the structure and function of neuronal proteins, especially of motor proteins and tau proteins and their pathological changes during neurodegeneration. He is head of a laboratory of the Max Planck Society at the German Electron Synchrotron DESY and is currently building a new research group at the DZNE site in Bonn.

Dr. Eva-Maria Mandelkow studied medicine and worked for several years as physician in the clinic and then shifted her focus to basic research. She earned her doctorate at the Max Planck Institute for Medical Research in Heidelberg on a topic in muscle physiology. In subsequent research stays at Brandeis University (Massachusetts, USA), Scripps Research Institute (La Jolla, California) and at the MRC Laboratory in Cambridge (United Kingdom) she worked on proteins of the cytoskeleton. Eva-Maria Mandelkow heads a research group at the Max Planck lab in Hamburg, which deals with cell and mouse models of Alzheimer's disease. She also moves to the DZNE in Bonn as a group leader in 2011.

Contact information:
Drs. Eva-Maria und Eckhard Mandelkow
Max Planck Research Unit for Structural Molecular Biology
c/o DESY, Notkestrasse 85, 22607 Hamburg
German Center for Neurodegenerative Diseases (DZNE)
Ludwig-Erhard-Allee 2, 53175 Bonn
Tel: +49 (0)40-89982801, +49 (0)228-43302-263
Email: office@mpasmb.desy.de, mandelkow@dzne.de
Dr. Katrin Weigmann
German Center for Neurodegenerative Diseases (DZNE)
Press- and Public Relations
Tel: +49 (0) 228 43302 /263
Mobil: +49 (0) 173 – 5471350
Email: katrin.weigmann@dzne.de

Katrin Weigmann | idw
Further information:
http://www.dzne.de
http://www.mpasmb-hamburg.mpg.de
http://www.aan.com/science/awards/?fuseaction=home.info&id=13

More articles from Awards Funding:

nachricht LandKlif: Changing Ecosystems
06.07.2018 | Julius-Maximilians-Universität Würzburg

nachricht “Future of Composites in Transportation 2018”, JEC Innovation Award for hybrid roof bow
29.06.2018 | Fraunhofer-Institut für Lasertechnik ILT

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Subaru Telescope helps pinpoint origin of ultra-high energy neutrino

16.07.2018 | Physics and Astronomy

Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides

16.07.2018 | Life Sciences

New research calculates capacity of North American forests to sequester carbon

16.07.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>