FIT would still be more cost-effective even if Cologuard and Cologuard Plus test costs were lowered to $100 Embargoed for release until 5:00 p.m. ET on Monday 12 May 2025 Follow @Annalsofim on X, Facebook, Instagram, threads, and Linkedin Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict…

Researchers at Amsterdam UMC followed 1955 young transmasculine and gender-diverse individuals, who used testosterone for an average of five years, finding no increased risk Transmasculine and gender-diverse individuals who use testosterone are not at increased risk of gynecological cancer in the first years of hormone therapy. This is evident from large-scale research by Amsterdam UMC, which was published today in eClinicalMedicine. The results provide important insights for healthcare providers and transmasculine and gender-diverse individuals who are considering starting hormone therapy….

CAR-T cells cause brain fog After treatment with CAR-T cells — immune cells engineered to attack cancer — patients sometimes tell their doctors they feel like they have “brain fog,” or forgetfulness and difficulty concentrating. A new Stanford Medicine-led study shows that CAR-T cell therapy causes mild cognitive impairments, independent of other cancer treatments, and that this happens via the same cellular mechanism as cognitive impairment from two other causes: chemotherapy and respiratory infections such as flu and COVID-19. The…

Microbial ecosystems have tipping points where even small perturbations are enough to cause a collapse, according to a new study. The authors, from the Helmholtz Institute for Functional Marine Biodiversity at the University of Oldenburg, Germany, describe microbial communities as a network based on cross-feeding, the exchange of metabolic by-products between populations. This network of relationships can collapse abruptly if individual populations are lost, they conclude. This mechanism may explain why microbial diversity is difficult to maintain in the laboratory,…

Researchers from the Keck School of Medicine of USC found that obesity, gestational diabetes and hypertensive disorders of pregnancy were tied to elevated blood pressure in offspring, with effects that grow as children age. Children born to mothers with obesity, gestational diabetes mellitus or a hypertensive disorder of pregnancy have higher systolic and diastolic blood pressure than children born to mothers without these risk factors, according to a new USC study. Among children whose mothers had at least one risk…

A team of researchers from the Department of Diagnostic and Therapeutic Ultrasonography at the Tianjin Medical University Cancer Institute & Hospital, have published a review (DOI: 10.20892/j.issn.2095-3941.2024.0376) in Cancer Biology & Medicine. The paper underscores the potential of AI to decode complex biological data with unprecedented speed and accuracy. By integrating genomics, medical imaging, and pathology at scale, AI is paving the way for data-driven strategies that bring precision medicine from theory into real-world clinical practice. In the realm of…

In an effort to curb misuse of opioids and prevent overdose deaths, the College of Physicians and Surgeons of British Columbia released a legally enforceable practice standard, Safe Prescribing of Drugs with Potential for Misuse/Diversion, in 2016. This document limited prescribing of opioids for chronic noncancer pain (CNCP) with specific prescribing practices that clinicians were obligated to follow. In research that tested the effects of the 2016 practice standard on prescribing to patients with CNCP, researchers found that its introduction had…

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous, accumulate in the environment and are difficult to break down. They are known as “forever chemicals”. PFAS can compromise the immune system and thus, human health. In their current study, researchers from the Helmholtz Centre for Environmental Research (UFZ) show that high PFAS exposure has a negative effect on the cellular immune response to the SARS-CoV-2 coronavirus. The scientists suspect that people exposed to high levels of PFAS may have a suboptimal immune…

New UBuffalo research indicates that while the residential segregation policy was outlawed decades ago, it still impacts women’s health today BUFFALO, N.Y. – In neighborhoods across America, women face a daunting threat from a federal practice that, although it was outlawed decades ago, continues to negatively impact their health today. That’s according to the findings of new University at Buffalo research that examines how historical redlining — the federal policy from the 1930s where neighborhoods were given mortgage security grades…

We report that METTL3, an oncogene regulates the expression of SMAD4, a tumor-suppressor via miR-146a-5p, thus unveiling a novel regulatory axis of METTL3/miR-146a-5p/SMAD4 in OSCC, which can potentially have therapeutic implications BUFFALO, NY – May 9, 2025 – A new research paper was published in Oncotarget, Volume 16, on May 8, 2025, titled “METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis.” In this study, researchers Jayasree Peroth Jayaprakash, Pragati Karemore, and Piyush Khandelia from the Birla Institute of Technology and Science, India,…

In pancreatic ductal adenocarcinoma (PDA), the abnormal colonization of fungal communities has become a research hotspot. Compared to normal tissue, the abundance of fungi in tumor tissues of PDA patients increased by up to 3000 times, with the enrichment of Malassezia being particularly significant. These fungi activate the host complement system (such as the MBL-C3 pathway), triggering local inflammatory responses and promoting tumor growth. This indicates that Malassezia is not only a “marker” in the tumor microenvironment but also a…

A research paper by scientists at Zhejiang University presented . The research paper, published on Apr. 11, 2025 in the journal Cyborg and Bionic Systems. Laparoscopic surgery for early gastric cancer has gained global popularity due to its notable short-term benefits and comparable oncological prognosis to open surgery. However, accurately locating early gastric cancer during laparoscopic surgery remains a challenge, as these tumors are limited to the mucous and submucosal membranes, making them undetectable through gross analysis of the serosa…

MAY 9, 2025, NEW YORK – A Ludwig Cancer Research study has identified a key mechanism by which advanced ovarian cancers suppress anti-tumor immune responses and resist immunotherapies. Led by Ludwig Princeton’s Lydia Lynch and reported in the current issue of Science Immunology, the study details how ascites fluid—produced in large quantities as ovarian cancer spreads from the ovaries into the abdomen and its organs—sabotages cytotoxic lymphocytes, a class of immune cells that kill cancer cells. “Although ascites fluid has…

Women who experience significant weight gain after the age of 20 and either have their first child after the age of 30 or don’t have children are almost three times more likely to develop breast cancer than those who give birth earlier and whose weight remains relatively stable, new research from the UK being presented at this year’s European Congress on Obesity (ECO 2025) has found. Previous research has shown that weight gain in adulthood increases the risk of developing…

Eye movements predict speed limits in perception If you quickly move a camera from object to object, the abrupt shift between the two points causes a motion smear that might give you nausea. Our eyes, however, do movements like these two or three times per second. These rapid movements are called saccades, and although the visual stimulus during a saccade shifts abruptly across the retina, our brain seems to keep it under the hood: we never perceive the shift. New…

Miniaturized Iontronic Micropipettes for Precise and Dynamic Ionic Modulation of Neuronal and Astrocytic Activity Researchers at Linköping University have developed a new type of pipette that can deliver ions to individual neurons without affecting the sensitive extracellular milieu. Controlling the concentration of different ions can provide important insights into how individual braincells are affected, and how cells work together. The pipette could also be used for treatments. Their study has been published in the journal Small. “In the long term,…