The progressive lack of the tumor suppressor gene Rb2/p130 could be an early indicator of prostate cancer in males, according to a study by researchers at Temple University’s College of Science and Technology.

The results of the study, “Expression of Cell-Cycle-regulated Proteins pRb2/p130, p107, p27kip1, p53, Mdm-2, and Ki-67 (MIB-1) in Prostatic Gland Adenocarcinoma,” appear in the June issue of Clinical Cancer Research ( clincancerres.aac

In the Arctic and Antarctic seas the water gets cold to minus 1.9 C in winter, but somehow some fish live there. These cold-blooded creatures survive in the icy water because the blood in their veins contains antifreeze proteins and glycoproteins. High levels of the antifreeze proteins are found in the blood serum, they are present in cell cytoplasm and all body fluids except urine. Due to their structure, molecules of antifreeze glycoproteins (AFGP) prevent growth of ice crystals. Natural antifreeze

A controversial research study here has found that exposing cells infected with feline immunodeficiency virus – a surrogate for HIV – to methamphetamine increases those cells’ ability to replicate the deadly virus as much as 15-fold.

The finding, if confirmed by ongoing animal studies, could answer important questions about how lentiviruses such as FIV and HIV can gain a foothold in the brain. That knowledge is vital in slowing or lessening the dementia that often accompanies AIDS and s

An unusual conifer found in a remote area of northern Vietnam has been identified as a genus and species previously unknown to science. The limestone ridges where the tree grows are among the most botanically rich areas in Vietnam, said Daniel Harder, currently director of the University of California at Santa Cruz (UCSC) Arboretum and a co-discoverer of the new species. The discovery is published in the current issue of the journal Novon.

“Biologists don’t need to contemplate finding life

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At the heart of every cell, vital information is “written” on the DNA, a long molecular ribbon almost one meter long bundled inside the nucleus of the cell. For the DNA to fit inside this small space, it is rolled up like a ball of yarn in a highly organized structure called chromatin. Beyond its purely structural role, the spatial organization of DNA is essential to the basic processes of a cell’s life because it provides information that is added to that contributed by the genetic code. This ball-

Researchers at the University of Cambridge have launched a major study to assess the benefits of screening for Type 2 diabetes. Type 2 is the most common type of diabetes, and is on the increase, due largely to the rise in obesity and sedentary lifestyles.

The study, named ADDITION, is based at the Department of Public Health and Primary Care. Launching the study, one of the Principal Investigators Dr Simon Griffin, explained its aim.

“Undetected diabetes is common and often people

Laboratory rats that have been repeatedly depleted of salt become sensitized to amphetamine, exhibiting an exaggerated hyperactive response to the drug and an unusual pattern of neuronal growth in a part of their brains, neuroscientists have found.

The researchers, headed by University of Washington psychologist Ilene Bernstein, discovered that nerve cells in the nucleus accumbens of sensitized rats have more branches and were 30 percent to 35 percent longer than normal. The nucleus accumbe

Heart ’patches’ and functioning kidney units cloned in cows

Advanced Cell Technology, Inc. (ACT) reported today that nuclear transplantation can be used to generate functional immune-compatible tissues. The research, which will appear in the July issue (cover story) of Nature Biotechnology, by ACT and its collaborators, provides the first experimental evidence that it may be possible to use cloning to generate medically important tissues and eliminate tissue rejection. Heart

Brown scientists have described a previously unknown but critical blood-clotting role for Arp2/3, a complex of seven proteins found in animal and plant cells.

Reporting in the June 15 issue of Blood, the scientists show that Arp2/3 complex is a cellular machine that drives a human blood platelet to change shape into a larger, more flattened form and begin the process of clotting. The link between what happens at the surface of a platelet and the mechanism of shape change within it has mystif

Cloned cells organize into muscle, heart and kidney tissue; animals show no rejection

Boston – In a study published in the July issue of Nature Biotechnology, available on the internet June 3, researchers from Children’s Hospital Boston and colleagues demonstrated that laboratory-engineered tissues created from heart, skeletal, and renal cells cloned from cows, then transplanted back into the animals, developed into functional tissues and caused no signs of rejection.

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Ph.D. candidate Lital Alfonta wins Kaye Award

Lital Alfonta, a Ph.D. candidate in the Faculty of Science at the Hebrew University of Jerusalem, has developed a fast, inexpensive test to determine if an AIDS patient has developed resistance to the medication he is taking. Ms. Alfonta was selected to receive the prestigious Kaye Innovation Award for her work, which could vastly improve treatment of AIDS patients.

Ms. Alfonta, who developed the test under the guidance of Prof.

Pulses of laser light can make molecules react in ways that are impossible using classical test-tube chemistry. Molecules vibrate, and each molecule has its own “tone,” its own “melody.” It’s a question of finding the right key, and that is something that a “smart” laser beam can do. It can find its way to the right tone. In a new issue of the prestigious journal Nature it is shown how such a laser can be used to control photosynthesis molecules that gather light. This is the first time this fea

Rising levels of gonorrhoea and syphilis across western Europe since 1995 imply that complacency over HIV prevention efforts may have set in among individuals and some governments, argue researchers in this week’s BMJ.

Angus Nicoll and Francoise Hamers examined national trends in diagnosed HIV infections, gonorrhoea, and infectious syphilis from 1995 to 2000.

They found the numbers of new diagnoses of sexually acquired HIV infections increased by 20% in western Europe. Rates of go

Popular arthritis drugs, known as selective COX 2 inhibitors, may not be superior to traditional non-steroidal anti-inflammatory drugs, conclude researchers in this week’s BMJ.

A study published in September 2000 concluded that the COX 2 inhibitor, celecoxib, was associated with a lower rate of stomach and intestinal ulcers than two older drugs for arthritis. However, only data for the first six months of the study were published. When all the data were considered, the published results appe

Scientists from Imperial College London have discovered that xenon gas could help in protecting damaged nerve cells.

The research, published today in Anesthesiology, shows that xenon, an inert gas, acts as a neuroprotectant, helping to protect damaged nerve cells from dying. Based upon pre-clinical trials, researchers believe it could have human applications, eventually leading to treatments for people suffering from nerve damaging illnesses, such as strokes, and brain and spinal cord injur