New study reveals how human astroviruses bind to humans cells and paves the way for new therapies and vaccines Human astroviruses are a leading viral cause of the stomach bug—think vomiting, diarrhea, and fever. It often impacts young children and older adults, leading to vicious cycles of sickness and malnutrition, particularly for those in low and middle income countries. It’s very commonly found in wastewater studies, meaning it’s frequently circulating in communities. As of now, there are no vaccines for…
Duke University chemists have developed a method of growing one-atom-thick cylinders of carbon, called “nanotubes,” 100 times longer than usual, while maintaining a soda-straw straightness with controllable orientation. Their achievement solves a major barrier to the nanotubes use in ultra-small “nanoelectronic” devices, said the teams leader.
The researchers have also grown checkerboard-like grids of the tubes which could form the basis of nanoscale electronic devices.
Leeds scientists are to investigate the birthplace of life – sea water billions of years old – with new high-tech laser equipment, the first of its kind in the UK.
The ancient sea water is found trapped in tiny pockets – called fluid inclusions – within crystals such as emerald and quartz. The oldest known examples are found in the rock 3.8 billion years old – the oldest land on the planet. Although liquid water is believed to have existed on earth over 4 billion years ago, obtaining samples
Johns Hopkins researchers have developed an inexpensive, reliable way to make large quantities of targeted immune cells that one day may provide a life-saving defense against cancers and viral infections.
Using artificial antigen presenting cells, or aAPCs, the scientists converted run-of-the-mill immune cells into a horde of specific, targeted invader-fighting machines, they report in the advance online version of Nature Medicine on April 21.
“The ability to make vast quantities
Scientists report for the first time that “baby” teeth, the temporary teeth that children begin losing around their sixth birthday, contain a rich supply of stem cells in their dental pulp. The researchers say this unexpected discovery could have important implications because the stem cells remain alive inside the tooth for a short time after it falls out of a childs mouth, suggesting the cells could be readily harvested for research.
According to the scientists, who published their
Rutgers Associate Professor Suzie Chen has discovered a gene responsible for melanoma, the most aggressive form of malignant skin cancer. A paper describing the research by Chen and her colleagues at the National Human Genome Research Institute will be published online by Nature Genetics on April 21, and will appear subsequently in a print issue of the journal.
Melanoma may appear in places that never see sun, spread to other parts of the body and become lethal. This type of cancer is not g
The lack of a special protein crucial to cell growth and development may help cancer cells proliferate, new research suggests.
Cells without this protein – E2F3 – are usually rendered genetically unstable. In most cases, such instability would either kill a cell or keep it from growing. Yet sometimes mutations alter cells in such a way that they are able to thrive and multiply, creating tumors.
“In cancer, the absence or loss of E2F3 may be a double-edged sword,” said Gustav
Vessels are important parts of our body. Their function is critical to our well-being. For years, doctors have tried various tools to take pictures of arteries that would help them in diagnosing or preventing diseases. This has not been an easy task, however, and sometimes they have to use imaging methods that may have some harmful side effects. It has always been a challenge to take clear pictures of vessel without the negative side effects. Here, we suggest a new way that may help us to achieve th
Finding is a significant step toward new insights for designing combination chemotherapy
Investigators at St. Jude Children’s Research Hospital have discovered numerous genes that alter their level of activity in characteristic patterns in response to specific chemotherapy treatments. The genes were identified in the leukemia cells of children undergoing chemotherapy for acute lymphoblastic leukemia (ALL).
The researchers say this finding is a significant step in the emergin
New high-speed imaging techniques are allowing scientists to show how a single cell mobilizes its resources to activate its immune response, a news research study shows.
Howard R. Petty, Ph.D., professor and biophysicist at the University of Michigan Health Systems Kellogg Eye Center, has dazzled his colleagues with movies of fluorescent-lit calcium waves that pulse through the cell, issuing an intracellular call-to-arms to attack the pathogens within.
He explains that these
A group of researchers led by the University of Colorado at Boulder have solved the crystal structure of a molecule switch that can trigger heart disease and cancer, paving the way for future drug designs to mitigate these diseases.
The key component of the switch is a protein called MEF2 that binds to the DNA and is involved in muscle cell, T cell and nerve cell development. In cases involving human hearts, it can lower gene activity that causes enlarged hearts, known as hypertrophic cardi
In a serendipitous spin-off of HIV/AIDS research, scientists at the National Institute of Allergy and Infectious Diseases (NIAID) and colleagues have found strong evidence that a genetic variation affecting immune system cells protects against heart disease. Details of the work, which also provides further evidence for the role of inflammation in heart disease, will appear in the April 15 issue of the Journal of Clinical Investigation.
“This work demonstrates how NIAIDs commitment to
Study sheds light on potential bioterror agent, Coxiella burnetii
Scientists at The Institute for Genomic Research (TIGR) and their collaborators have deciphered and analyzed the complete genome sequence of Coxiella burnetii, a potential bioterror agent that causes Q Fever.
C. burnetii, which was first isolated as the cause of Q Fever in Australia in 1937, is typically found in farm animals but also infects humans, including an epidemic that sickened many soldiers in Europe
New research at North Carolina State University’s College of Veterinary Medicine indicates that cloned pigs can have the same degree of variability in physical appearance and behavior as normally bred animals. Two separate studies show that while clones are genetically identical to the original animal, the similarities end there.
This dispels the commonly held notion that cloned animals retain the physical and behavioral attributes of the animal from which they were cloned. The research was
Scientists are now one step closer to understanding how HIV hides in cells and rears its ugly head once patients stop taking combination drug therapy, which can suppress viral loads to undetectable levels. The phenomenon reflects the existence of hidden populations of latently infected cells. As a result, patients must remain on therapy for life.
Eradication of these cells could lead to a cure for HIV infection. However, researchers have been hampered by their inability to identify them.
New research led by a University of North Carolina at Chapel Hill scientist shows for the first time how Mycobacterium tuberculosis, the germ responsible for TB, uses a system for releasing proteins to help it survive the lungs immune defenses to spread and cause disease.
The study, published online in the April issue of Molecular Microbiology, also adds crucial new knowledge to the molecular factors that underlie the virulence of M. tuberculosis and may aid development of new, target
Millions of people suffering from diabetes mellitus may be spared the ordeal of pricking their fingers several times a day to test blood sugar levels, thanks to a breakthrough by University of Pittsburgh researchers who have developed a non-invasive method to measure the glucose level in bodily fluids.
Researchers Sanford A. Asher, Ph.D., professor of chemistry in the faculty and College of Arts and Sciences, and David Finegold, M.D., professor of pediatrics in the School of Medicine, creat