How do tumours develop in the cervix? Many new details are now known about this question. This is also thanks to Dr. Cindrilla Chumduri from the Biocentre at the University of Würzburg. Organoids are increasingly being used in biomedical research. These are organ-like structures created in the laboratory that are only a few millimetres in size. Organoids can be used to study life processes and the effect of drugs. Because they closely resemble real organs, they offer several advantages over…

380 million years ago, fish started to crawl out of the water to colonise land. The Australian lungfish – an endangered, air-breathing fish – is one of the few living relatives of these first land explorers. A team of researchers sequenced its giant genome for the first time, unveiling the species’ unique evolutionary history and striking similarities to land-dwelling vertebrates. The study, published in the journal “Nature”, sets a record for the largest animal genome ever sequenced. The Australian lungfish…

Researchers have solved the operating mode of the barrel pore protein assembly in the mitochondrial outer membrane Mitochondria are vital for the human body as cellular powerhouses: They possess more than 1,000 different proteins, required for many central metabolic pathways. Disfunction of these lead to severe diseases, especially of the nervous system and the heart. In order to transport proteins and metabolites, mitochondria contain a special group of so-called beta-barrel membrane proteins, which form transport pores in the outer mitochondrial…

Results of fundamental research provide possible basis for the development of drugs active against the pathogen / New class of inhibitors attack papain-like viral protease / Efficacy against SARS-CoV and SARS-CoV-2 in cell cultures While the first vaccines have been developed against the pathogen SARS-CoV-2, studies are still underway to identify effective drugs for treating coronavirus infections. Scientists in Gießen, Mainz, and Würzburg in Germany involved in a fundamental research project have now identified potential starting points that could contribute…

Filariae, slender but sometimes up to 70 centimeters long nematodes, can set up residence in their host quite tenaciously and cause serious infectious diseases in the tropics. The tiny larvae of the worms are usually transmitted from person to person by mosquitoes, which pick up the larvae from the blood or subcutaneous tissue when they bite and deposit them in the vessels or tissues of their next victim. Researchers led by the University of Bonn have now investigated a mechanism…

Acetals are important chemical compounds that are used, for example, in the production of certain medical agents. A new method now makes their synthesis easier and more environmentally friendly. Chemists at the University of Bonn have developed and optimized the sustainable catalytic process. State-of-the-art computer simulations were also used. The reaction is based on a mechanism that frequently occurs in nature, but has rarely been used in chemical synthesis up to now. The results are published in the journal Angewandte…

New probes allow scientists to see four-stranded DNA interacting with molecules inside living human cells, unravelling its role in cellular processes. DNA usually forms the classic double helix shape of two strands wound around each other. While DNA can form some more exotic shapes in test tubes, few are seen in real living cells. However, four-stranded DNA, known as G-quadruplex, has recently been seen forming naturally in human cells. Now, in new research published today in Nature Communications, a team…

In experiments in mouse tissues and human cells, Johns Hopkins Medicine researchers say they have found that removing a membrane that lines the back of the eye may improve the success rate for regrowing nerve cells damaged by blinding diseases. The findings are specifically aimed at discovering new ways to reverse vision loss caused by glaucoma and other diseases that affect the optic nerve, the information highway from the eye to the brain. “The idea of restoring vision to someone…

If you want to understand an ecosystem, look at what the species within it eat. In studying food webs — how animals and plants in a community are connected through their dietary preferences — ecologists can piece together how energy flows through an ecosystem and how stable it is to climate change and other disturbances. Studying ancient food webs can help scientists reconstruct communities of species, many long extinct, and even use those insights to figure out how modern-day communities…

What if the degenerative eye conditions that lead to glaucoma, corneal dystrophy, and cataracts could be detected and treated before vision is impaired? Recent findings from the lab of Investigator Ting Xie, PhD, at the Stowers Institute for Medical Research point to the ciliary body as a key to unlocking this possibility. Previous work from the lab showed that when mouse stem cells were differentiated into light-sensing photoreceptor cells in vitro, and then transplanted back into mice with a degenerative…

A group of scientists led by the American Museum of Natural History and Bat Conservation International have discovered a new species of a striking orange and black bat in a mountain range in West Africa. The species, which the researchers expect is likely critically endangered, underscores the importance of sub-Saharan “sky islands” to bat diversity. The species is described today in the journal American Museum Novitates. “In an age of extinction, a discovery like this offers a glimmer of hope,”…

New study finds octopuses adapting to higher ocean acid levels. With the impact of climate change increasing by the day, scientists are studying the ways in which human behavior contributes to the damage. A recent study at Walla Walla University, by a collaboration of researchers from Walla Walla University and La Sierra University, examined the effects of acidic water on octopuses, potentially bringing new insight into both how our activities impact the world around us, and the way that world…

The Ludwig Boltzmann Institute Digital Health and Patient Safety has analyzed previously published scientific publications on open innovation in the context of medical and pharmaceutical research. The results of the study was accepted for publication in the Frontiers in Pharmacology. Open innovation (OI) in the context of medical and pharmaceutical research began to appear in the scientific literature in mid-2000s and has been steady on the rise. This is revealed by the analysis of around 380 relevant scientific publications, conducted…

Remdesivir is the first drug against Covid-19 to be conditionally approved in Europe and the United States. The drug is designed to suppress the rapid replication of the SARS-CoV-2 virus in human cells by blocking the viral copying machine, called RNA polymerase. Researchers at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the University of Würzburg have now elucidated how remdesivir interferes with the viral polymerase during copying and why it does not inhibit it completely. Their…

Antiviral protein MDA-5 senses viral replication and governs immune response to SARS-CoV-2. Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified the sensor in human lungs that detects SARS-CoV-2 and signals that it’s time to mount an antiviral response. The study, published today in Cell Reports, provides insights into the molecular basis of severe disease and may enable new strategies for the treatment and prevention of COVID-19. “Our research has shown that MDA-5 is the immune cop that’s tasked…

Method presents the immune system with several different coronaviruses at once. The SARS-CoV-2 virus that is causing the COVID-19 pandemic is just one of many different viruses in the coronavirus family. Many of these are circulating in populations of animals like bats and have the potential to “jump” into the human population, just as SARS-CoV-2 did. Researchers in the laboratory of Pamela Björkman, the David Baltimore Professor of Biology and Bioengineering, are working on developing vaccines for a wide range…